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4/30/2021Grand RoundsSusanna Naggie; Elizabeth ShenkmanDuke Clinical Research Institute; University of FloridaACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications Drs. Naggie and Shenkman discuss the ACTIV-6 direct-to-participants trial of COVID-19 treatments evaluating repurposed drugs.
  
4/30/2021Grand RoundsSusanna Naggie; Elizabeth ShenkmanDuke Clinical Research Institute; University of FloridaACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications Drs. Naggie and Shenkman discuss the ACTIV-6 direct-to-participants trial of COVID-19 treatments evaluating repurposed drugs.
  
4/23/2021Grand RoundsSamuel BrownUniversity of UtahCOVID Clinical Trials: The Intermountain Healthcare ExperienceDr. Brown presents the challenges and successes of integrating COVID-19 clinical research in the Intermountain Healthcare system during the pandemic.
  
4/23/2021Grand RoundsSamuel BrownUniversity of UtahCOVID Clinical Trials: The Intermountain Healthcare ExperienceDr. Brown presents the challenges and successes of integrating COVID-19 clinical research in the Intermountain Healthcare system during the pandemic.
  
4/16/2021Grand RoundsTyler Winkelman; Paul DrawzUniversity of Minnesota; Hennepin Healthcare Research InstituteMinnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine Equity Drs. Winkelman and Drawz describe how the Minnesota Electronic Health Record Consortium is informing COVID-19 vaccine equity in Minnesota.
  
4/16/2021Grand RoundsTyler Winkelman; Paul DrawzUniversity of Minnesota; Hennepin Healthcare Research InstituteMinnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine EquityDrs. Winkelman and Drawz describe how the Minnesota Electronic Health Record Consortium is informing COVID-19 vaccine equity in Minnesota.
  
4/9/2021Grand RoundsAdit GindeUniversity of Colorado School of MedicineTaking Research to the Participant: Experiences with TREAT NOW, a No-Touch COVID-19 Trial Dr. Ginde presents experiences with an ongoing “no-touch” clinical trial on COVID-19 treatments.
  
4/2/2021Grand RoundsDerek AngusUniversity of PittsburghLessons from COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform Trial Dr. Angus describes the adaptive platform trial REMAP-CAP and how it was expanded to evaluate treatment interventions for patients hospitalized with COVID-19.
  
4/2/2021Grand RoundsDerek AngusUniversity of PittsburghLessons from COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform TrialDr. Angus describes the adaptive platform trial REMAP-CAP and how it was expanded to evaluate treatment interventions for patients hospitalized with COVID-19.
  
3/26/2021Grand RoundsRobert GreenHarvard Medical School; Massachusetts General HospitalThe Path to Preventive Genomics Dr. Green discusses the role of genomics in predicting, and potentially preventing, the onset of disease in healthy people.
  
3/26/2021Grand RoundsRobert GreenHarvard Medical School; Massachusetts General HospitalThe Path to Preventive Genomics Dr. Green discusses the role of genomics in predicting, and potentially preventing, the onset of disease in healthy people.
  
3/19/2021Grand RoundsEmily O'Brien; Robert CaliffDuke Clinical Research Institute; Verily Life SciencesHERO–Learning Together about Vaccines for SARS-CoV-2 Drs. O’Brien and Califf discuss the HERO Program supporting research around COVID-19 vaccines in the community of healthcare workers.
  
3/19/2021Grand RoundsEmily O'Brien; Robert CaliffDuke Clinical Research Institute; Verily Life SciencesHERO–Learning Together about Vaccines for SARS-CoV-2 Drs. O’Brien and Califf discuss the HERO Program supporting research around COVID-19 vaccines in the community of healthcare workers.
  
3/12/2021Grand RoundsJintanat Ananworanich; Mohamed BassyouniBill and Melinda Gates Medical Research InstituteLessons Learned from the Gates MRI Virtual COVID-19 TrialDrs. Bassyouni and Ananworanich discuss the innovative COVID-19 therapeutics accelerator program established by the Gates Medical Research Institute.
  
3/12/2021Grand RoundsJintanat Ananworanich; Mohamed BassyouniBill and Melinda Gates Medical Research InstituteLessons Learned from the Gates MRI Virtual COVID-19 TrialDrs. Bassyouni and Ananworanich discuss the innovative COVID-19 therapeutics accelerator program established by the Gates Medical Research Institute.
  
3/5/2021Grand RoundsSusan EllenbergUniversity of PennsylvaniaData and Safety Monitoring Boards for Trials of COVID-19 Vaccines: The Challenges Dr. Ellenberg describes challenges encountered by the DSMB that is monitoring a group of COVID-19 vaccine trials under the National Institutes of Health.
  
3/5/2021Grand RoundsSusan EllenbergUniversity of PennsylvaniaData and Safety Monitoring Boards for Trials of COVID-19 Vaccines: The ChallengesDr. Ellenberg describes challenges encountered by the DSMB that is monitoring a group of COVID-19 vaccine trials under the National Institutes of Health.
  
2/26/2021Grand RoundsSebastian SchneeweissHarvard Medical SchoolCalibrating Real-World Evidence Against RCT Evidence: Early Learnings from RCT-DUPLICATEDr. Schneeweiss discusses how real-world evidence (RWE) studies can emulate randomized clinical trials.
  
2/26/2021Grand RoundsSebastian SchneeweissHarvard Medical SchoolCalibrating Real-World Evidence Against RCT Evidence: Early Learnings from RCT-DUPLICATE Dr. Schneeweiss discusses how real-world evidence (RWE) studies can emulate randomized clinical trials.
  
2/19/2021Grand RoundsKevin SchulmanStanford UniversityBeyond Politics: Promoting COVID Vaccination in the United States Dr. Schulman discusses 12 strategies for promoting COVID-19 vaccination.
  
2/19/2021Grand RoundsKevin SchulmanStanford UniversityBeyond Politics: Promoting COVID Vaccination in the United States Dr. Schulman discusses 12 strategies for promoting COVID-19 vaccination.
  
2/12/2021Grand RoundsLesley Curtis; Bradley Hammill; Sudha RamanDuke University School of MedicineLeveraging RWD in a Multinational Trial: Results from the Other eHARMONY [HARMONY Outcomes EHR Ancillary Study] Drs. Curtis, Hammill, and Raman discuss the outcomes of the eHARMONY ancillary study and lessons learned about the fitness of real-world data for use in clinical trials.
  
2/12/2021Grand RoundsLesley Curtis; Bradley Hammill; Sudha RamanDuke University School of MedicineLeveraging RWD in a Multinational Trial: Results from the Other eHARMONY [HARMONY Outcomes EHR Ancillary Study] Drs. Curtis, Hammill, and Raman discuss the outcomes of the eHARMONY ancillary study and lessons learned about the fitness of real-world data for use in clinical trials.
  
2/5/2021Grand RoundsRenato LopesDuke Clinical Research InstituteGenerating High-Quality Evidence During a Pandemic: The Brazilian COALITION Experience Dr. Lopes describes how randomized clinical trials are essential to the generation of high-quality evidence needed for clinical decision making.
  
2/5/2021Grand RoundsRenato LopesDuke Clinical Research InstituteGenerating High-Quality Evidence During a Pandemic: The Brazilian COALITION Experience Dr. Lopes describes how randomized clinical trials are essential to the generation of high-quality evidence needed for clinical decision making.
  
1/29/2021Grand RoundsGregory MarcusUniversity of California, San FranciscoThe COVID-19 Citizen Science Study Dr. Marcus discusses the COVID-19 Citizen Science project that is using the Eureka digital research platform.
  
1/29/2021Grand RoundsGregory MarcusUniversity of California, San FranciscoThe COVID-19 Citizen Science Study Dr. Marcus discusses the COVID-19 Citizen Science project that is using the Eureka digital research platform.
  
1/22/2021Grand RoundsHarlan Krumholz; Joseph RossYale University School of MedicineIs It Time to Embrace Preprints? A Conversation About the First 18 Months of medRxivDrs. Krumholz and Ross discuss the benefits of, and concerns about, using medRxiv, a preprint server for health science research that aims to be a service to the scientific community.
  
1/22/2021Grand RoundsHarlan Krumholz; Joseph RossYale University School of MedicineIs It Time to Embrace Preprints? A Conversation About the First 18 Months of medRxiv Drs. Krumholz and Ross discuss the benefits of, and concerns about, using medRxiv, a preprint server for health science research that aims to be a service to the scientific community.
  
1/15/2021Grand RoundsPamela Tenaerts; Sara Calvert; LeAnne MadreClinical Trials Transformation Initiative (CTTI)How CTTI & the Clinical Trials Community Have Risen to Meet the Challenge of the COVID-19 Pandemic A panel of presenters from the Clinical Trials Transformation Initiative (CTTI) discusses how CTTI has helped the clinical trials ecosystem evolve and move forward during the COVID-19 pandemic.
  
1/15/2021Grand RoundsPamela Tenaerts; Sara Calvert; LeAnne MadreClinical Trials Transformation Initiative (CTTI)How CTTI & the Clinical Trials Community Have Risen to Meet the Challenge of the COVID-19 Pandemic A panel of presenters from the Clinical Trials Transformation Initiative (CTTI) discusses how CTTI has helped the clinical trials ecosystem evolve and move forward during the COVID-19 pandemic.
  
1/8/2021Grand RoundsEmily O'BrienDuke Clinical Research Institute; Duke University School of MedicineHERO-TOGETHER: Building Vaccine Confidence With Long-Term Outcomes DataDr. O’Brien discusses the HERO-TOGETHER initiative that aims to understand how healthcare workers do after receiving a COVID-19 vaccination.
  
1/8/2021Grand RoundsEmily O'BrienDuke Clinical Research Institute; Duke University School of MedicineHERO-TOGETHER: Building Vaccine Confidence With Long-Term Outcomes DataDr. O’Brien discusses the HERO-TOGETHER initiative that aims to understand how healthcare workers do after receiving a COVID-19 vaccination.
  
12/18/2020Grand RoundsMatthew Shun-ShinImperial College LondonThe SAMSON Trial: An N-of-1 Trial of Statin, Placebo, and No Treatment to Assess Patient Symptoms Dr. Shun-Shin describes the design and results of the SAMSON trial that evaluated perceived side effects of statin medications.
  
12/18/2020Grand RoundsMatthew Shun-ShinImperial College LondonThe SAMSON Trial: An N-of-1 Trial of Statin, Placebo, and No Treatment to Assess Patient Symptoms Dr. Shun-Shin describes the design and results of the SAMSON trial that evaluated perceived side effects of statin medications.
  
12/11/2020Grand RoundsSchuyler Jones ; Karen AlexanderDuke University; Duke Clinical Research InstitutePREVENTABLE: Starting a Pragmatic Trial in a PandemicDrs. Alexander and Jones describe the challenges of starting a trial during the COVID-19 pandemic.
  
12/11/2020Grand RoundsKaren Alexander; Schuyler Jones Duke Clinical Research Institute; Duke UniversityPREVENTABLE: Starting a Pragmatic Trial in a Pandemic Drs. Alexander and Jones describe the challenges of starting a trial during the COVID-19 pandemic.
  
12/4/2020Grand RoundsTariq AhmadYale University School of MedicineThe Yale New Haven Health System as an Evidence Generation Ecosystem for Heart FailureDr. Ahmad discusses studies evaluating data-driven methodologies for predicting clinical outcomes in patients with heart failure.
  
12/4/2020Grand RoundsTariq AhmadYale University School of MedicineThe Yale New Haven Health System as an Evidence Generation Ecosystem for Heart FailureDr. Ahmad discusses studies evaluating data-driven methodologies for predicting clinical outcomes in patients with heart failure.
  
11/20/2020Grand RoundsDaniel EdmonstonDuke University School of MedicineDrug Development in Kidney Disease: Proceedings from a Multi-Stakeholder Panel Dr. Edmonston describes the landscape of drug development and clinical trials evaluating treatments for chronic kidney disease.
  
11/20/2020Grand RoundsDaniel EdmonstonDuke University School of MedicineDrug Development in Kidney Disease: Proceedings from a Multi-Stakeholder PanelDr. Edmonston describes the landscape of drug development and clinical trials evaluating treatments for chronic kidney disease.
  
11/13/2020Grand RoundsMerrick Zwarenstein; Amit Garg; Ahmed Al-JaishiMcMaster University; Western UniversityPragmatic and Explanatory Attitudes to RCTs: Using the PRECIS-2 Tool to Describe the Design of the MyTEMP Trial Drs. Zwarenstein, Al-Jaishi, and Garg discuss the differences between explanatory and pragmatic approaches to randomized controlled trials as illustrated by two contrasting trials.
  
11/13/2020Grand RoundsMerrick Zwarenstein; Amit Garg; Ahmed Al-JaishiMcMaster University; Western UniversityPragmatic and Explanatory Attitudes to RCTs: Using the PRECIS-2 Tool to Describe the Design of the MyTEMP Trial Drs. Zwarenstein, Al-Jaishi, and Garg discuss the differences between explanatory and pragmatic approaches to randomized controlled trials as illustrated by two contrasting trials.
  
11/6/2020Grand RoundsDavid FlumUniversity of WashingtonAppendectomy Versus Antibiotics for Appendicitis–Early Results from the CODA Trial Dr. Flum discusses the CODA comparative effectiveness trial that compared two treatments for appendicitis.
  
11/6/2020Grand RoundsDavid FlumUniversity of WashingtonAppendectomy Versus Antibiotics for Appendicitis–Early Results from the CODA Trial Dr. Flum discusses the CODA comparative effectiveness trial that compared two treatments for appendicitis.
  
10/30/2020Grand RoundsDavid BoulwareUniversity of MinnesotaLessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience Dr. Boulware describes how his study team was able to rapidly set up virtual clinical trials during the early days of the COVID-19 pandemic.
  
10/30/2020Grand RoundsDavid BoulwareUniversity of MinnesotaLessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience Dr. Boulware describes how his study team was able to rapidly set up virtual clinical trials during the early days of the COVID-19 pandemic.
  
10/23/2020Grand RoundsJoAnn Sperl-Hillen; Patrick O'ConnorHealthPartners InstituteOutpatient Clinical Decision Support – An Evidence-Based Implementation Framework Drs. Sperl-Hillen and O’Connor share lessons learned in the development of a clinical decision support system used in primary care visits.
  
10/23/2020Grand RoundsJoAnn Sperl-Hillen; Patrick O'ConnorHealthPartners InstituteOutpatient Clinical Decision Support – An Evidence-Based Implementation Framework Drs. Sperl-Hillen and O’Connor share lessons learned in the development of a clinical decision support system used in primary care visits.
  
10/16/2020Grand RoundsDanny Benjamin; Kanecia ZimmermanDuke Clinical Research Institute; Duke University School of MedicineBack to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative Drs. Zimmerman and Benjamin discuss the ABC Science Collaborative, which aims to unite science and schools for a data-driven solution to decision-making and implementation around mitigating COVID-19.
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