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Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

  
  
  
  
  
  
Engagement in Research for Pragmatic Clinical Trials3/30/2020Guidance document
  
Living Textbook Grand Rounds Series: Part 3-Tips for Putting Together a Successful PCT Grant Application 3/27/2020Grand Rounds
  
Living Textbook Grand Rounds Series: Part 3-Tips for Putting Together a Successful PCT Grant Application 3/27/2020Video
  
Clinical Trials in the Time of COVID-19 3/20/2020Grand Rounds
  
Intraclass Correlation Coefficient Cheat Sheet3/16/2020Handout
  
Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions 3/13/2020Grand Rounds
  
Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions 3/13/2020Video
  
Creating a Learning Health System Through Randomization 3/6/2020Grand Rounds
  
Creating a Learning Health System Through Randomization 3/6/2020Video
  
LIRE Public Use Dataset and Data Dictionary3/5/2020Public use dataset
  
LIRE Computable Phenotypes3/5/2020Computable phenotype
  
AcuOA Ethics and Regulatory Discussion2/28/2020Meeting summary
  
NOHARM Ethics and Regulatory Discussion2/28/2020Ethics and regulatory documentation
  
FM TIPS Ethics and Regulatory Discussion2/28/2020Ethics and regulatory documentation
  
OPTIMUM Ethics and Regulatory Discussion2/28/2020Ethics and regulatory documentation
  
Living Textbook Grand Rounds Series: Part 2-Preparing for the Unknown: Conducting Pragmatic Research in Real-World Contexts2/28/2020Grand Rounds
  
Living Textbook Grand Rounds Series: Part 2-Preparing for the Unknown: Conducting Pragmatic Research in Real-World Contexts2/28/2020Video
  
TiME Closeout Data and Resource Sharing Checklist2/26/2020Data and Resource Sharing Checklist
  
TiME Closeout Snapshot2/26/2020Handout
  
ePCT Factsheet 20202/25/2020Handout
  
Nudge Study Updates2/21/2020Grand Rounds
  
Nudge Study Updates2/21/2020Video
  
NIH Collaboratory Communication Channels2/19/2020Handout
  
Do Our Current Research Models Meet the Needs of a Learning Health Care System? 2/14/2020Grand Rounds
  
Do Our Current Research Models Meet the Needs of a Learning Health Care System? 2/14/2020Video
  
Using Nudges to Improve the Delivery of Health Care 2/7/2020Grand Rounds
  
Using Nudges to Improve the Delivery of Health Care 2/7/2020Video
  
Using Nudges to Improve the Delivery of Health Care2/7/2020Podcast
  
Design and analytic considerations for using patient-reported health data in pragmatic clinical trials: report from an NIH Collaboratory roundtable2/6/2020Journal article
  
HiLo Study Snapshot2/5/2020Handout
  
ePCT Quick Start Guide2/5/2020Handout
  
NIH Implementation Team Chart2/5/2020Handout
  
LIRE Closeout Data and Resource Sharing Checklist2/3/2020Data and Resource Sharing Checklist
  
Living Textbook Grand Rounds Series Part 1: Pragmatic Clinical Trials: How Do I Start?1/31/2020Grand Rounds
  
Living Textbook Grand Rounds Series Part 1: Pragmatic Clinical Trials: How Do I Start? 1/31/2020Video
  
NIH Collaboratory Distributed Research Network (DRN) Handout1/30/2020Handout
  
Design and implementation of a clinical decision support tool for Primary Palliative Care for Emergency Medicine (PRIM-ER)1/28/2020Journal article
  
Cardiovascular Trials Over 2 Decades: Progress on Pragmatism? 1/24/2020Grand Rounds
  
Cardiovascular Trials Over 2 Decades: Progress on Pragmatism? 1/24/2020Video
  
Assessment of the Human Systemic Absorption of Sunscreen Active Ingredients: FDA-Sponsored Randomized Clinical Trial1/17/2020Grand Rounds
  
Assessment of the Human Systemic Absorption of Sunscreen Active Ingredients: FDA-Sponsored Randomized Clinical Trial1/17/2020Video
  
Pragmatic Trials of Behavioral Economic Interventions to Increase Colorectal Cancer Screening1/10/2020Grand Rounds
  
Pragmatic Trials of Behavioral Economic Interventions to Increase Colorectal Cancer Screening1/10/2020Video
  
Statement by Individual Leaders and Investigators Involved in Pragmatic Clinical Trials Embedded in Healthcare Systems1/9/2020
  
Considerations for using distributed research networks to conduct aspects of randomized trials1/2/2020Journal article
  
Ethics and collateral findings in pragmatic clinical trials1/1/2020Journal article
  
Response to Open Peer Commentaries on 'Ethics and collateral findings in pragmatic clinical trials'1/1/2020Journal article
  
Evaluation of a Level I trauma center provider training in alcohol brief intervention delivery within a 25-site trial of screening and intervention for PTSD and related comorbidity12/29/2019Journal article
  
EMBED Update: Challenges and Solutions12/13/2019Grand Rounds
  
EMBED Update: Challenges and Solutions12/13/2019Video
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