Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

  
  
  
  
  
  
I CAN DO Surgical ACP Ethics and Regulatory Discussion12/4/2023Ethics and regulatory documentationThis document contains the meeting minutes and supplementary materials for the I CAN DO Surgical ACP Demonstration Project
  
Guidelines for Design and Analysis of Stepped-Wedge Trials12/1/2023Grand RoundsDr. James P. Hughes discusses guidelines for design and analysis of stepped-wedge trials.
  
Guidelines for Design and Analysis of Stepped-Wedge Trials12/1/2023Grand RoundsDr. James P. Hughes discusses guidelines for design and analysis of stepped-wedge trials.
  
ePCT Factsheet11/22/2023HandoutInformation sheet about the NIH Collaboratory and pragmatic clinical trials
  
Nudge Study Snapshot11/20/2023HandoutStudy snapshot of the Nudge Demonstration Project
  
ACP PEACE Study Snapshot11/20/2023HandoutSnapshot of the ACP PEACE Demonstration Project
  
BeatPain Utah Study Snapshot11/20/2023HandoutStudy snapshot of the BeatPain Utah Demonstration Project
  
GGC4H Study Snapshot11/17/2023HandoutSnapshot of the GGC4H Demonstration Project
  
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study11/17/2023Grand RoundsDrs. Michael Ho and Sheana Bull discuss Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study.
  
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study11/17/2023Grand RoundsDrs. Michael Ho and Sheana Bull discuss Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study.
  
Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial11/13/2023PodcastDr. Harlan M. Krumholz discusses lessons from the digital, decentralized and democratized Yale PaxLC Trial.
  
ABATE Infection Study Snapshot11/7/2023HandoutCloseout snapshot of the ABATE Infection Demonstration Project
  
HiLo Study Snapshot11/7/2023HandoutStudy snapshot of the HiLo Demonstration Project
  
PROVEN Study Snapshot11/7/2023HandoutCloseout snapshot of the PROVEN Demonstration Project
  
FM-TIPS Study Snapshot11/7/2023HandoutStudy snapshot of the FM TIPS Demonstration Project
  
BackInAction Study Snapshot11/7/2023HandoutStudy snapshot of the BackInAction Demonstration Project
  
NOHARM Study Snapshot11/7/2023HandoutStudy snapshot of the NOHARM Demonstration Project
  
INSPIRE Study Snapshot11/7/2023HandoutStudy snapshot of the INSPIRE Demonstration Project
  
IMPACt-LBP Study Snapshot11/7/2023HandoutSnapshot of the IMPACt-LBP Demonstration Project
  
The Perils and Pitfalls of Complex Clustering in Pragmatic Trials11/3/2023Grand RoundsDr. Jonathan Moyer discusses the perils and pitfalls of complex clustering in pragmatic trials.
  
The Perils and Pitfalls of Complex Clustering in Pragmatic Trials11/3/2023Grand RoundsDr. Jonathan Moyer discusses the perils and pitfalls of complex clustering in pragmatic trials.
  
Onboarding Meeting November 2023 - AIM-CP11/1/2023PresentationAIM-CP PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - ARBOR-Telehealth 11/1/2023PresentationARBOR-Telehealth PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - I CAN DO Surgical ACP11/1/2023PresentationI CAN DO Surgical ACP PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - iPATH11/1/2023PresentationiPATH PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - MOMs 11/1/2023PresentationMOMs PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - RAMP11/1/2023PresentationRAMP PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - CC Overview and Goals11/1/2023PresentationLesley Curtis provides an overview of the CC at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - Collaboratory Overview & Cooperative Agreement11/1/2023PresentationBeda Jean-Francois provides an overview of the Collaboratory and a cooperative agreement at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - Lessons Learned11/1/2023PresentationDemonstration Project PIs provide an overview of lessons learned at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - Program Policies and Guidance Documents11/1/2023PresentationPlatt and Uhlenbrauck present on program policies and guidance documents at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - Agenda11/1/2023AgendaAgenda for the Nov. 2023 Collaboratory Virtual Onboarding Meeting
  
Onboarding Meeting November 2023 - Participant List11/1/2023Participant ListParticipant list for the Nov. 2023 Collaboratory Virtual Onboarding Meeting
  
October 31, 2023: NIH Pragmatic Trials Collaboratory Welcomes 5 New Demonstration Projects10/31/2023News article
  
NIH I Team Chart with POs and PSs10/30/2023HandoutThe NIH Implementation Team includes NIH staff who support individual Demonstration Projects.
  
Collaboratory 2023 Onboarding Mtg 2 eBinder_Final10/30/2023e-Binder for November 1, 2023 Onboarding Meeting
  
Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial10/27/2023Grand RoundsDr. Harlan M. Krumholz discusses lessons from the digital, decentralized and democratized Yale PaxLC Trial.
  
Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial10/27/2023Grand RoundsDr. Harlan M. Krumholz discusses lessons from the digital, decentralized and democratized Yale PaxLC Trial.
  
What Are Common Pitfalls in Writing PCT Grant Applications?10/20/2023TranscriptDr. Wendy Weber discusses common pitfalls in writing PCT grant applications.
  
Is it Important to Explain the Definition of Pragmatic to Grant Reviewers?10/20/2023TranscriptDr. Wendy Weber discusses if it is important to explain the definition of pragmatic to grant reviewers.
  
What Are the “Must Dos” of Writing PCT Grant Applications?10/20/2023TranscriptDr. Wendy Weber discusses the "must dos" of writing PCT grant applications.
  
What Should I Avoid When Writing PCT Grant Applications?10/20/2023TranscriptDr. Wendy Weber discusses what to avoid when writing PCT grant applications.
  
What Are Some Success Strategies When Writing PCT Grant Applications?10/20/2023TranscriptDr. Wendy Weber discusses success strategies for writing PCT grant applications.
  
How Do You Design Trials That Are Fit for Purpose?10/20/2023TranscriptDr. Lesley Curtis discusses how to design trials that are fit for purpose.
  
What Are Pragmatic Clinical Trials?10/20/2023TranscriptDr. Lesley Curtis describes pragmatic clinical trials.
  
Why Should I Do a Pragmatic Trial?10/20/2023TranscriptDr. Lesley Curtis discusses reasons to conduct pragmatic clinical trials.
  
A National Initiative to Eliminate Hepatitis C in the United States – Why This Matters to Clinical Trialists10/20/2023Grand RoundsDrs. Rachael L. Fleurence and Joshua M. Sharfstein discuss a national initiative to eliminate Hepatitis C in the U.S.
  
A National Initiative to Eliminate Hepatitis C in the United States – Why This Matters to Clinical Trialists10/20/2023Grand RoundsDrs. Rachael L. Fleurence and Joshua M. Sharfstein discuss a national initiative to eliminate Hepatitis C in the U.S.
  
What Do Endpoints and Outcomes Look Like in Pragmatic Trials?10/19/2023TranscriptDr. Devon Check discusses endpoints and outcomes in pragmatic trials.
  
How Do Data Sources Inform the Choice of Endpoints and Outcomes in Pragmatic Trials?10/19/2023TranscriptDr. Devon Check discusses how data sources inform the choice of endpoints and outcomes in pragmatic trials.
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