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Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit

Leveraging RWE to Support Regulatory Decisions--An Update on Efforts to Inform Policy3/15/2019Grand Rounds
Dietary Trials in Heart Failure: SODIUM-HF3/8/2019Grand Rounds
Approaches to Patient Follow-Up for Clinical Trials: What’s the Right Choice for Your Study?3/1/2019Grand Rounds
Going from a Learning Health System to Learning Health Units- Opportunities and Challenges2/22/2019Grand Rounds
ABATE Data Request Form2/21/2019Checklist
ABATE Routine Care Protocol (Arm 1)2/21/2019Toolkit
ABATE Decolonization Protocol (Arm 2)2/21/2019Toolkit
Paramedic Airway Management in Out-of-Hospital Cardiac Arrest – The Pragmatic Airway Resuscitation Trial (PART)2/19/2019Podcast
Improving Qualification of Investigators: Recommendations from the Clinical Trials Transformation Initiative 2/15/2019Grand Rounds
Paramedic Airway Management in Out-of-Hospital Cardiac Arrest – The Pragmatic Airway Resuscitation Trial (PART)2/8/2019Grand Rounds
Promoting Effective Advance Care Planning Communication in the Elderly: The ACP-PEACE Trial2/1/2019Grand Rounds
Publishing Agreement for Rethinking Clinical Trials®: A Living Textbook of Pragmatic Clinical Trials2/1/2019Policy
Perinatal Outcomes Associated with a Major Change in Gestational Diabetes Screening 1/29/2019Podcast
A Learning Health System Story: Perinatal Outcomes Associated with a Major Change in Gestational Diabetes Screening1/25/2019Grand Rounds
Pragmatic Trials in End-stage Renal Disease (ESRD): HiLo1/18/2019Grand Rounds
Introduction to ePCTs: Self-Paced Study1/17/2019Presentation
Response to FDA Proposed Rule on  Consent1/16/2019Regulatory
Nudge: Text Messaging at Scale in Diverse Health Systems to Support Adherence to Cardiac Medication1/11/2019Grand Rounds
TRANSFORMing Research for Patients With Heart Failure1/4/2019Grand Rounds
Pragmatic clinical trials offer unique opportunities for disseminating, implementing, and sustaining evidence-based practices into clinical care: Proceedings of a workshop12/26/2018Journal article
Guiding Good Choices for Health (GGC4H): Testing Feasibility and Effectiveness of Universal Parent-Focused Prevention in Three Healthcare Systems12/14/2018Grand Rounds
Documentation Checklist (Word)12/10/2018Checklist
Documentation Checklist (PDF)12/10/2018Checklist
Cluster Randomized Trials in Health Care Delivery Systems: Lessons from STIC2IT12/7/2018Grand Rounds
Validating a Computable Phenotype12/5/2018Podcast
Implementation Readiness Checklist (Word)12/3/2018Checklist
Implementation Readiness Checklist (PDF)12/3/2018Checklist
Validating a Computable Phenotype: Should Results Change a Trial’s Pre-Specified Primary Outcome?11/30/2018Grand Rounds
Rapid Assessment Procedure Informed Clinical Ethnography (RAPICE) in Pragmatic Clinical Trials of Mental Health Services Implementation: Methods and Applied Case Study11/28/2018Journal article
Data Linkage Within, Across, and Beyond PCORnet 11/20/2018Podcast
Task-shifting to improve the reach of mental health interventions for trauma patients: findings from a pilot study of trauma nurse training in patient-centered activity scheduling for PTSD and depression11/20/2018Journal article
Primary Palliative Care for Emergency Medicine (PRIM-ER)11/16/2018Grand Rounds
Comparison of Natural Language Processing Rules-based and Machine-learning Systems to Identify Lumbar Spine Imaging Findings Related to Low Back Pain11/15/2018Journal article
Data Linkage Within, Across, and Beyond PCORnet11/9/2018Grand Rounds
Final report ADAPTABLE Supplement Patient Reported Health data elements11/7/2018Guidance document
MDEpiNet RAPID and SPEED Projects: Leveraging Real World Evidence to Get Better, Faster, Cheaper Medical Devices for Physicians and Patients11/7/2018Podcast
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