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Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

Name
  
Title
  
Resource Date
  
Resource Type
  
Resource_Description
  
  
Dissemination Opportunities Handout2/4/2026HandoutThis handout offers examples of strategies beyond academic publications to help investigators plan for broad dissemination.
  
Cost-effectiveness of acupuncture needling for older adults with chronic low back pain2/1/2026Journal articlePublication from BackInAction
  
NIH Collaboratory Program Overview Slides1/30/2026PresentationA presentation of the NIH Collaboratory’s goals, organizational structure, and trials.
  
NIH Pragmatic Trials Collaboratory Program Overview Handout1/30/2026HandoutThis handout gives an overview of the NIH Pragmatic Trials Collaboratory.
  
NIH Pragmatic Trials Collaboratory Program Accomplishments1/30/2026HandoutThis handout summarizes the accomplishments of the NIH Pragmatic Trials Collaboratory.
  
NIH Pragmatic Trials Collaboratory Program Impact Slides1/30/2026PresentationThis slide deck provides information about the impact of the NIH Pragmatic Trials Collaboratory.
  
Living Textbook Handout1/30/2026HandoutThis handout gives an overview of the Living Textbook of Pragmatic Clinical Trials.
  
A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being1/30/2026Grand RoundsDrs. Majid Afshar and Mary Ryan Baumann discuss “A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being.”
  
A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being1/30/2026Grand RoundsDrs. Majid Afshar and Mary Ryan Baumann discuss “A Pragmatic Randomized Controlled Trial of Ambient Artificial Intelligence to Improve Health Practitioner Well-Being.”
  
Implementation Readiness Checklist (Word)1/29/2026ChecklistChecklist of items to consider for readiness to begin implementation
  
Implementation Readiness Checklist (PDF)1/29/2026ChecklistChecklist of items to consider for readiness to begin implementation
  
January 26, 2026: New Findings From GRACE Trial Highlight Strategies for Integrating Acupuncture and Guided Relaxation Into Sickle Cell Disease Clinics1/26/2026News article
  
DASH-Patterned Groceries Reduce Blood Pressure: Results from the GoFreshRandomized Clinical Trial1/23/2026Grand RoundsDr. Stephen P. Juraschek discusses “DASH-Patterned Groceries Reduce Blood Pressure: Results from the GoFreshRandomized Clinical Trial.”
  
DASH-Patterned Groceries Reduce Blood Pressure: Results from the GoFreshRandomized Clinical Trial1/23/2026Grand RoundsDr. Stephen P. Juraschek discusses “DASH-Patterned Groceries Reduce Blood Pressure: Results from the GoFreshRandomized Clinical Trial.”
  
Pre-implementation barriers and facilitators to integrating complementary and integrative health interventions into clinic workflow: The GRACE trial, NIH Pragmatic Trials Collaboratory1/20/2026Journal articlePublication from GRACE
  
NIH Implementation Team Chart1/16/2026HandoutThe NIH Implementation Team includes NIH staff who support individual Demonstration Projects.
  
Financial Incentives to Promote Diverse Participation in Alzheimer’s Disease Research1/16/2026Grand RoundsDr. Mireille Jacobson discusses the impact of financial incentives on diverse participation in a memory concerns registry.
  
Financial Incentives to Promote Diverse Participation in Alzheimer’s Disease Research1/16/2026Grand RoundsDr. Mireille Jacobson discusses the impact of financial incentives on diverse participation in a memory concerns registry.
  
January 12, 2026: Enhanced Acupuncture Strategy Found to Be Cost-Saving in Older Adults With Chronic Low Back Pain1/12/2026News article
  
Pragmatic Care Embedded Randomization: Insights From the KP-VACCINATE Megatrial1/9/2026Grand RoundsDr. Ankeet S. Bhatt discusses Pragmatic Care Embedded Randomization: Insights From the KP-VACCINATE Megatrial.
  
Pragmatic Care Embedded Randomization: Insights From the KP-VACCINATE Megatrial1/9/2026Grand RoundsDr. Ankeet S. Bhatt discusses Pragmatic Care Embedded Randomization: Insights From the KP-VACCINATE Megatrial.
  
January 8, 2026: Study Design Paper Published for BEST-ICU1/8/2026News article
  
December 31, 2025: New Podcast Explores INSPIRE Trial Results and Drivers of Intervention Success12/31/2025News article
  
Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout: Lessons Learned and Future Directions12/19/2025Grand RoundsDrs. Olson, Meeker, and Schwamm discuss the use of ambient AI scribes to reduce physician burnout in ambulatory clinics.
  
Use of Ambient AI Scribes to Reduce Administrative Burden and Professional Burnout: Lessons Learned and Future Directions12/19/2025Grand RoundsDrs. Olson, Meeker, and Schwamm discuss the use of ambient AI scribes to reduce physician burnout in ambulatory clinics.
  
December 15, 2025: A Year of Trial Results and Innovations From the NIH Pragmatic Trials Collaboratory12/15/2025News article
  
AcademyHealth D&I Workshop 2025 Program Overview12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 Speaker Bios12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 Agenda12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - ACP PEACE12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - Welcome - O'Brien12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - BeatPain Utah12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - ePCTs and Hybrid Trials - Bosworth12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - Design Analysis Monitoring - Yu12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - Measuring Outcomes-Volandes12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - ePCTs in Context_Panel 1 - O'Brien12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - Pilot Feasibility - Mudd12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - Ethics Regulatory - Morain12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - Engaging Partners - Bosworth12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - Posttrial Sustainment - Mor12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - LungSMART Utah12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - ePCTs in Context_Panel 2 - Morain12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - Writing Grant - Jean-Francois12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 Participant Guide12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - PROVEN12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2025 - RAMP12/14/2025HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination and Implementation in Embedded Pragmatic Trials: Science-Powered Strategies to Sustain and Spread Effect," at AcademyHealth's 18th Annual Dissemination and Implementation Conference.
  
BEST-ICU Study Design Paper12/12/2025Study design paperBEST-ICU Study Design Paper
  
December 11, 2025: New Resource Promotes Community Health Improvement in Pragmatic Trials12/11/2025News article
  
December 8, 2025: New Podcast Explores Partnership Between Rural-Focused Research Network and BeatPain, an NIH Collaboratory Trial12/8/2025
  
December 3, 2025: Results From the FM-TIPS Trial, in This Week’s Rethinking Clinical Trials Grand Rounds12/3/2025News article
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