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Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

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Engagement in Research for Pragmatic Clinical Trials3/30/2020Guidance document
  
Living Textbook Grand Rounds Series: Part 3-Tips for Putting Together a Successful PCT Grant Application 3/27/2020Grand Rounds
  
Living Textbook Grand Rounds Series: Part 3-Tips for Putting Together a Successful PCT Grant Application 3/27/2020Video
  
Clinical Trials in the Time of COVID-19 3/20/2020Grand Rounds
  
Intraclass Correlation Coefficient Cheat Sheet3/16/2020Handout
  
Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions 3/13/2020Grand Rounds
  
Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions 3/13/2020Video
  
Creating a Learning Health System Through Randomization 3/6/2020Grand Rounds
  
Creating a Learning Health System Through Randomization 3/6/2020Video
  
LIRE Public Use Dataset and Data Dictionary3/5/2020Public use dataset
  
LIRE Computable Phenotypes3/5/2020Computable phenotype
  
AcuOA Ethics and Regulatory Discussion2/28/2020Meeting summary
  
NOHARM Ethics and Regulatory Discussion2/28/2020Ethics and regulatory documentation
  
FM TIPS Ethics and Regulatory Discussion2/28/2020Ethics and regulatory documentation
  
OPTIMUM Ethics and Regulatory Discussion2/28/2020Ethics and regulatory documentation
  
Living Textbook Grand Rounds Series: Part 2-Preparing for the Unknown: Conducting Pragmatic Research in Real-World Contexts2/28/2020Grand Rounds
  
Living Textbook Grand Rounds Series: Part 2-Preparing for the Unknown: Conducting Pragmatic Research in Real-World Contexts2/28/2020Video
  
TiME Closeout Data and Resource Sharing Checklist2/26/2020Data and Resource Sharing Checklist
  
TiME Closeout Snapshot2/26/2020Handout
  
ePCT Factsheet 20202/25/2020Handout
  
Nudge Study Updates2/21/2020Grand Rounds
  
Nudge Study Updates2/21/2020Video
  
NIH Collaboratory Communication Channels2/19/2020Handout
  
Do Our Current Research Models Meet the Needs of a Learning Health Care System? 2/14/2020Grand Rounds
  
Do Our Current Research Models Meet the Needs of a Learning Health Care System? 2/14/2020Video
  
Using Nudges to Improve the Delivery of Health Care 2/7/2020Grand Rounds
  
Using Nudges to Improve the Delivery of Health Care 2/7/2020Video
  
Using Nudges to Improve the Delivery of Health Care2/7/2020Podcast
  
Design and analytic considerations for using patient-reported health data in pragmatic clinical trials: report from an NIH Collaboratory roundtable2/6/2020Journal article
  
HiLo Study Snapshot2/5/2020Handout
  
ePCT Quick Start Guide2/5/2020Handout
  
NIH Implementation Team Chart2/5/2020Handout
  
LIRE Closeout Data and Resource Sharing Checklist2/3/2020Data and Resource Sharing Checklist
  
Living Textbook Grand Rounds Series Part 1: Pragmatic Clinical Trials: How Do I Start?1/31/2020Grand Rounds
  
Living Textbook Grand Rounds Series Part 1: Pragmatic Clinical Trials: How Do I Start? 1/31/2020Video
  
NIH Collaboratory Distributed Research Network (DRN) Handout1/30/2020Handout
  
Design and implementation of a clinical decision support tool for Primary Palliative Care for Emergency Medicine (PRIM-ER)1/28/2020Journal article
  
Cardiovascular Trials Over 2 Decades: Progress on Pragmatism? 1/24/2020Grand Rounds
  
Cardiovascular Trials Over 2 Decades: Progress on Pragmatism? 1/24/2020Video
  
Assessment of the Human Systemic Absorption of Sunscreen Active Ingredients: FDA-Sponsored Randomized Clinical Trial1/17/2020Grand Rounds
  
Assessment of the Human Systemic Absorption of Sunscreen Active Ingredients: FDA-Sponsored Randomized Clinical Trial1/17/2020Video
  
Pragmatic Trials of Behavioral Economic Interventions to Increase Colorectal Cancer Screening1/10/2020Grand Rounds
  
Pragmatic Trials of Behavioral Economic Interventions to Increase Colorectal Cancer Screening1/10/2020Video
  
Statement by Individual Leaders and Investigators Involved in Pragmatic Clinical Trials Embedded in Healthcare Systems1/9/2020
  
Considerations for using distributed research networks to conduct aspects of randomized trials1/2/2020Journal article
  
Ethics and collateral findings in pragmatic clinical trials1/1/2020Journal article
  
Response to Open Peer Commentaries on 'Ethics and collateral findings in pragmatic clinical trials'1/1/2020Journal article
  
Evaluation of a Level I trauma center provider training in alcohol brief intervention delivery within a 25-site trial of screening and intervention for PTSD and related comorbidity12/29/2019Journal article
  
EMBED Update: Challenges and Solutions12/13/2019Grand Rounds
  
EMBED Update: Challenges and Solutions12/13/2019Video
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