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Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

Name
  
Title
  
Resource Date
  
Resource Type
  
Resource_Description
  
  
March 11, 2025: Study Design Paper Published for MOMs Chat & Care Study3/11/2025News article
  
A Trial of a “Kidney Action Team” for Hospitalized Patients with Acute Kidney Injury3/7/2025Grand RoundsDr. F. Perry Wilson discusses a trial of a “Kidney Action Team” for hospitalized patients with acute kidney injury.
  
A Trial of a “Kidney Action Team” for Hospitalized Patients with Acute Kidney Injury3/7/2025Grand RoundsDr. F. Perry Wilson discusses a trial of a “Kidney Action Team” for hospitalized patients with acute kidney injury.
  
March 4, 2025: PRIM-ER Team Develops Innovative Statistical Techniques for Stepped-Wedge Trials3/4/2025News article
  
Bayesian hierarchical penalized spline models for immediate and time-varying intervention effects in stepped wedge cluster randomized trials2/28/2025Journal articlePublication from PRIM-ER
  
Behavioral Economic and Staffing Strategies To Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU)2/28/2025Grand RoundsDrs. Eduard Vasilevskis and Michele C. Balas discuss “Behavioral Economic and Staffing Strategies to Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU).”
  
Behavioral Economic and Staffing Strategies to Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU)2/28/2025Grand RoundsDrs. Eduard Vasilevskis and Michele C. Balas discuss “Behavioral Economic and Staffing Strategies to Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU).”
  
Monitoring in pragmatic trials lessons from the NIH Pragmatic Trials Collaboratory2/25/2025Journal articlePublication from the Coordinating Center
  
February 24, 2025: Study Snapshots and Updated Ethics Documentation Available for 3 NIH HEAL Initiative–Supported Trials in Rural Populations2/24/2025News article
  
RAMP Study Snapshot2/21/2025HandoutStudy snapshot of the RAMP trial
  
Texting for Behavior Change: Lessons Learned Across Two Interventions to Improve Chronic Care Management2/21/2025Grand RoundsDrs. Michael Ho and Sheana Bull discuss “Texting for Behavior Change: Lessons Learned Across Two Interventions to Improve Chronic Care Management.”
  
Texting for Behavior Change: Lessons Learned Across Two Interventions to Improve Chronic Care Management2/21/2025Grand RoundsDrs. Michael Ho and Sheana Bull discuss “Texting for Behavior Change: Lessons Learned Across Two Interventions to Improve Chronic Care Management.”
  
MOMs Chat & Care Study Design Paper2/21/2025Study design paperMOMs Chat & Care Study Design Paper
  
ICD-Pieces Study Snapshot2/20/2025HandoutStudy snapshot of the ICD-Pieces trial
  
February 19, 2025: Texting for Behavior Change to Improve Chronic Care Management, in This Week’s PCT Grand Rounds2/19/2025News article
  
February 12, 2025: Results of ACP PEACE, an NIH Collaboratory Trial, in This Week’s PCT Grand Rounds2/12/2025News article
  
Improving Symptom Control in Pediatric Cancer Patients with SSPedi and SPARK2/7/2025Grand RoundsDr. Lillian Sung discusses improving symptom control in pediatric cancer patients with SSPedi and SPARK.
  
Improving Symptom Control in Pediatric Cancer Patients with SSPedi and SPARK2/7/2025Grand RoundsDr. Lillian Sung discusses improving symptom control in pediatric cancer patients with SSPedi and SPARK.
  
NIH Pragmatic Trials Collaboratory Program Overview Handout1/31/2025HandoutThis handout gives an overview of the NIH Pragmatic Trials Collaboratory.
  
NIH Pragmatic Trials Collaboratory Program Accomplishments1/31/2025HandoutThis handout summarizes the accomplishments of the NIH Pragmatic Trials Collaboratory.
  
NIH Pragmatic Trials Collaboratory Program Impact Slides1/31/2025PresentationThis slide deck provides information about the impact of the NIH Pragmatic Trials Collaboratory.
  
Living Textbook Handout1/31/2025HandoutThis handout gives an overview of the Living Textbook of Pragmatic Clinical Trials.
  
Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned1/31/2025Grand RoundsDrs. Skolasky and McLaughlin discuss “Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned.”
  
Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned1/31/2025Grand RoundsDrs. Skolasky and McLaughlin discuss “Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned.”
  
Acute care use and prognosis in older adults presenting to the emergency department1/31/2025Journal articlePublication from the PRIM-ER trial
  
NIH Collaboratory Program Overview Slides1/30/2025PresentationA presentation of the NIH Collaboratory’s goals, organizational structure, and trials.
  
January 29, 2025: Early Lessons From ARBOR-Telehealth, an NIH Collaboratory Trial, in This Week’s PCT Grand Rounds1/29/2025News article
  
NIH Pragmatic Trials Collaboratory Publications Process Handout1/27/2025PolicyThis document shows the NIH Collaboratory publications and presentations review process.
  
January 27, 2025: Study Snapshot and Updated Ethics Documentation Available for TAICHIKNEE1/27/2025News article
  
ARBOR-Telehealth Study Snapshot1/27/2025HandoutStudy snapshot of the ARBOR-Telehealth trial
  
AIM-CP Ethics and Regulatory Follow-up1/27/2025Ethics and regulatory documentationThis document contains the updated meeting minutes for the AIM-CP trial.
  
NIH Collaboratory Communication Channels1/24/2025HandoutGraphic depiction of the communications channels in the NIH Health Care Systems Research Collaboratory Program
  
The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths 1/24/2025Grand RoundsDr. Jeffrey H. Samet discusses “The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths.”
  
The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths 1/24/2025Grand RoundsDr. Jeffrey H. Samet discusses “The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths.”
  
January 21, 2025: In PRIM-ER Trial, Palliative Care Training in Emergency Departments Did Not Reduce Hospital Admissions1/21/2025News article
  
TAICHIKNEE Ethics and Regulatory Follow-up1/17/2025Ethics and regulatory documentationThis document contains the updated meeting minutes for the TAICHIKNEE trial.
  
"Design for Diversity: Designing Studies for Representativeness and Generalizability."1/17/2025Grand RoundsDr. Lindsell discusses "Design for Diversity: Designing Studies for Representativeness and Generalizability."
  
"Design for Diversity: Designing Studies for Representativeness and Generalizability."1/17/2025Grand RoundsDr. Lindsell discusses "Design for Diversity: Designing Studies for Representativeness and Generalizability."
  
PRIM-ER Main Outcome Paper1/15/2025Main outcome paperPRIM-ER Main Outcome Paper
  
NIH Pragmatic Trials Collaboratory Publications Policy1/14/2025PolicyThis document describes the NIH Pragmatic Trials Collaboratory publications and presentations policy.
  
January 14, 2025: Ethics Consultation Documents Now Available for APA-SM Trial1/14/2025News article
  
APA-SM Ethics and Regulatory Discussion1/13/2025Ethics and regulatory documentationThis document contains the meeting minutes and supplementary materials for the APA-SM trial.
  
January 13, 2024: STEP-2 Trial of Cervical Cancer Screening Interventions Joins the NIH Collaboratory1/13/2025News article
  
FM-TIPS Community Engagement Methods for Recruitment1/10/2025Grand RoundsDrs. Heather Schacht Reisinger and Dana Dailey discuss FM-TIPS Community Engagement Methods for Recruitment.
  
FM-TIPS Community Engagement Methods for Recruitment1/10/2025Grand RoundsDrs. Heather Schacht Reisinger and Dana Dailey discuss FM-TIPS Community Engagement Methods for Recruitment.
  
January 8, 2025: In This Week’s PCT Grand Rounds, Community Engagement Methods in the FM-TIPS Trial1/8/2025News article
  
Onboarding Meeting January 2025: Agenda1/8/2025AgendaAgenda for the Jan. 2025 Collaboratory Virtual Onboarding Meeting
  
Onboarding Meeting January 2025 - Participant List1/8/2025Participant ListParticipant list for the Jan. 2025 Collaboratory Virtual Onboarding Meeting
  
Onboarding Meeting January 2025 - Collaboratory Overview & Cooperative Agreement1/8/2025PresentationWendy Weber provides an overview of the Collaboratory and a cooperative agreement at the Jan. 2025 Onboarding Meeting.
  
Onboarding Meeting January 2025 - CC Overview1/8/2025PresentationAdrian Hernandez provides an overview of the CC at the Jan. 2025 Onboarding Meeting
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