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Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

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Exploring Approaches in Using Digital and Mobile Health in Patient-oriented Research: Pearls and Pitfalls11/19/2021Grand RoundsDr. Anish Agarwal discusses the rapidly changing landscape of digital and mobile devices in patient-oriented research.
  
Exploring Approaches in Using Digital and Mobile Health in Patient-oriented Research: Pearls and Pitfalls11/19/2021Grand RoundsDr. Anish Agarwal discusses the rapidly changing landscape of digital and mobile devices in patient-oriented research.
  
NIH-Collaboratory-Program-Overview11/15/2021A PDF presentation of the Collaboratory’s goals and organizational structure along with a brief introduction of each Demonstration Project
  
Incentives and payments in pragmatic clinical trials: scientific, ethical, and policy considerations11/12/2021Journal articlePublication from the Ethics and Regulatory Core
  
Using Financial Incentives to Increase COVID-19 Vaccine Uptake11/12/2021Grand RoundsDr. Wong and Dr. Brewer discuss the results of a financial incentive program to encourage COVID-19 vaccination in North Carolina.
  
Using Financial Incentives to Increase COVID-19 Vaccine Uptake11/12/2021Grand RoundsDr. Wong and Dr. Brewer discuss the results of a financial incentive program to encourage COVID-19 vaccination in North Carolina.
  
 November 9, 2021: PPACT Study Finds Benefits of Cognitive Behavioral Therapy in Reducing Chronic Pain and Pain-Related Disability11/9/2021News articleNews article about PPACT.
  
Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU Study11/5/2021Grand RoundsDr. James Grotta discusses the BEST-MSU Study and the benefits of stroke treatment delivered using a mobile stroke unit compared to standard management by emergency medical services.
  
Benefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU Study11/5/2021Grand RoundsDr. James Grotta discusses the BEST-MSU Study and the benefits of stroke treatment delivered using a mobile stroke unit compared to standard management by emergency medical services.
  
Embedding Pragmatic Trials into Emergency and Critical Care10/29/2021Grand RoundsDr. Semler and Dr. Casey discuss the challenges of embedding pragmatic trials into emergency and critical care.
  
Embedding Pragmatic Trials into Emergency and Critical Care10/29/2021Grand RoundsDr. Semler and Dr. Casey discuss the challenges of embedding pragmatic trials into emergency and critical care.
  
Increasing Engagement in Advance Care Planning and Lessons Learned from Partnering with Community Ambulatory Practices10/22/2021Grand RoundsDr. Fried shares the results of the STAMP Trial, a cluster-randomized trial to increase patient engagement in Advance Care Planning.
  
The STAMP Trial: Increasing Engagement in Advance Care Planning and Lessons Learned from Partnering with Community Ambulatory Practices10/22/2021Grand RoundsDr. Fried shares the results of the STAMP Trial, a cluster-randomized trial to increase patient engagement in Advance Care Planning.
  
 October 21, 2021: NIH Collaboratory Launches IMPACt-LBP Demonstration Project10/21/2021News articleNews article about IMPACt-LBP launch.
  
The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh10/15/2021Grand RoundsDr. Abaluck shares the results of a cluster-randomized trial examining the impact of community masking on COVID-19 in Bangladesh.
  
The Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in Bangladesh10/15/2021Grand RoundsDr. Abaluck shares the results of a cluster-randomized trial examining the impact of community masking on COVID-19 in Bangladesh.
  
Lessons Learned and Patient Partnership in ADAPTABLE10/8/2021Grand RoundsDr. Schuyler Jones and Madelaine Faulkner discuss patient engagement and study design in the ADAPTABLE aspirin trial.
  
Lessons Learned and Patient Partnership in ADAPTABLE10/8/2021Grand RoundsDr. Schuyler Jones and Madelaine Faulkner discuss patient engagement and study design in the ADAPTABLE aspirin trial.
  
October 6, 2021: MOTIFS Team Shares Lessons From Multi-Method Study of Collateral Findings in Pragmatic Trials10/6/2021News articleNews article on MOTIFS.
  
October 5, 2021: New Article Identifies Challenges and Prerequisites for Using Electronic Health Record Systems for Pragmatic Research10/5/2021News articleNews article about article on EHRs
  
Enhancing the use of EHR systems for pragmatic embedded research: lessons from the NIH Health Care Systems Research Collaboratory10/1/2021Journal articlePublication from the Electronic Health Records Core
  
COVID-OUT: From Computer Modeling to a Phase III Trial of Early Outpatient Treatment for SARS-CoV-2 Infection10/1/2021Grand RoundsDr. Bramante, Dr. Murray, and Dr. Huling discuss the design and progress of the COVID-OUT Trial for early outpatient treatment of SARS-CoV-2 infection.
  
COVID-OUT: From Computer Modeling to a Phase III Trial of Early Outpatient Treatment for SARS-CoV-2 Infection10/1/2021Grand RoundsDr. Bramante, Dr. Murray, and Dr. Huling discuss the design and progress of the COVID-OUT Trial for early outpatient treatment of SARS-CoV-2 infection.
  
A prospective US national trauma center study of firearm injury survivors weapon carriage and posttraumatic stress disorder symptoms10/1/2021Journal articlePublication from the TSOS Demonstration Projects
  
September 30, 2021: BeatPain Utah and GRACE Awarded Continuation to Implementation Phase9/30/2021News articleNews about BeatPain Utah and Grace.
  
MOTIFS Publication: Identification and management of pragmatic clinical trial collateral findings: A current understanding and directions for future research9/29/2021Journal articlePublication from the MOTIFS supplement
  
Enabling Patient-Reported Outcome Measures (PROMs) in Clinical Trials, Exemplified by Cardiovascular Trials 9/24/2021Grand RoundsDr. Coles and Dr. Weinfurt discuss Patient-Reported Outcome Measures (PROMs) and the importance of Modern Validity Theory in developing PROMs.
  
Enabling Patient-Reported Outcome Measures (PROMs) in Clinical Trials, Exemplified by Cardiovascular Trials 9/24/2021Grand RoundsDr. Coles and Dr. Weinfurt discuss Patient-Reported Outcome Measures (PROMs) and the importance of Modern Validity Theory in developing PROMs.
  
September 23, 2021: PCO Core Aims for Greater Consistency in Integrating Patient-Reported Outcomes in Research and Clinical Care9/23/2021News articlePCO core update.
  
September 22, 2021: PCT Grand Rounds Explores Enabling Patient-Reported Outcome Measures in Clinical Trials9/22/2021News articleNews announcing GR on PROs.
  
September 20, 2021: Vince Mor to Present on Challenges to Implementing Innovative Programs in Long-Term Care9/20/2021News articleNews article on Vince Mor presentation.
  
Patient, provider, and clinic characteristics associated with opioid and non-opioid pain prescriptions for patients receiving low back imaging in primary care9/19/2021Journal articlePublication from the LIRE Demonstration Project
  
September 15, 2021: PCT Grand Rounds to Announce Primary Results of NIH Collaboratory’s Suicide Prevention Outreach Trial (SPOT)9/15/2021News articleNews article about SPOT.
  
Effect of Salt Substitution on Cardiovascular Events and Death9/10/2021Grand RoundsDr. Neal shares the results from the SSaSS study on the effects of reduced-sodium, added-potassium salt substitute on stroke, cardiovascular events, and death.
  
Effect of Salt Substitution on Cardiovascular Events and Death9/10/2021Grand RoundsDr. Neal shares the results from the SSaSS study on the effects of reduced-sodium, added-potassium salt substitute on stroke, cardiovascular events, and death.
  
Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial8/27/2021Grand RoundsDr. Hibbert shares the results from the CAPITAL DOREMI study and discusses the importance of randomized pragmatic clinical trials to generate quality data on therapeutics.
  
Milrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial 8/27/2021Grand RoundsDr. Hibbert shares the results from the CAPITAL DOREMI study and discusses the importance of randomized pragmatic clinical trials to generate quality data on therapeutics.
  
OPTIMUM Study Design Paper8/27/2021Study design paperOPTIMUM Study Design Paper
  
Promoting Both Internal and External Validity: Designing the Trial to Match Its Intention8/26/2021White PaperThis is an introduction to help researchers match the design of their trial to its purpose while maintaining both internal and external validity.
  
August 26, 2021: Li Receives PCORI Award to Study Methods for Cluster Randomized Trials8/26/2021News articleNews article about PCORI award.
  
 August 23, 2021: BeatPain Utah Takes Pragmatic Research to New Frontiers8/23/2021News articleNew article about BeatPain Utah.
  
Fluvoxamine for early treatment of COVID-19: the STOP COVID clinical trials8/20/2021Grand RoundsDr. Eric Lenze discusses the STOP COVID trials, the latest research on Fluvoxamine for the early treatment of COVID-19.
  
Fluvoxamine for early treatment of COVID-19: the STOP COVID clinical trials8/20/2021Grand RoundsDr. Eric Lenze discusses the STOP COVID trials, the latest research on Fluvoxamine for the early treatment of COVID-19.
  
August 19, 2021: Biostatistics Core Helps Projects ‘Roll With the Punches’ of the Pandemic8/19/2021News articleNews article about the Biostats Core.
  
Zelen design clinical trials: why, when, and how8/17/2021Journal articlePublication from the SPOT Demonstration Project
  
August 16, 2021: MOTIFS Explores Patients’ Reactions to Notifications of Collateral Findings8/16/2021News articleNews article about a MOTIFS publication
  
Got anything for this cough? Outpatient Treatment Trials in the Time of COVID8/13/2021Grand RoundsDr. Smith discusses the history of proposed therapies for COVID-19 and how the Adaptive Platform Trial ACTIV -2 seeks to find a successful new therapy.
  
Got anything for this cough? Outpatient Treatment Trials in the Time of COVID8/13/2021Grand RoundsDr. Smith discusses the history of proposed therapies for COVID-19 and how the Adaptive Platform Trial ACTIV -2 seeks to find a successful new therapy.
  
MOTIFS Publication: Patients' reactions to letters communicating collateral findings of pragmatic clinical trials: a national web-based survey8/12/2021Journal articlePublication from the MOTIFS supplement
  
August 11, 2021: EHR Core Facing Familiar Challenges, Intensified by Pandemic8/11/2021News articleNews article about the EHR Core
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