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Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

Name
  
Title
  
Resource Date
  
Resource Type
  
Resource_Description
  
  
July 20, 2026: Practical Tips for Dissemination: An Interview With Hayden Bosworth and Cherise Harrington7/20/2026News article
  
July 16, 2026: New Living Textbook Section on Pragmatic Trials in Underresourced Clinics7/16/2026News article
  
July 14, 2026: Investigators for Closing Pragmatic Trials Reflect on NIH Collaboratory Experience7/14/2026News article
  
A Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (Slides)7/10/2026Grand RoundsDr. Weiss discusses “A Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS).”
  
A Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (Video)7/10/2026Grand RoundsDr. Weiss discusses “A Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis (PRoMPT BOLUS).”
  
BackInAction Data and Resource Sharing Checklist7/9/2026Data and Resource Sharing Checklist
  
July 9, 2026: Updates From the EquiP PC Trial: An Interview With Kari Stephens7/9/2026News article
  
PRIM-ER Research Team Materials7/9/2026ImplementationPRIM-ER research team materials
  
PRIM-ER Site Materials7/9/2026Implementation materialsPRIM-ER site materials
  
BackInAction Data Collection Forms7/9/2026Data collection formBackInAction data collection forms
  
FM-TIPS Clinician and Site Materials7/8/2026Implementation materialsFM-TIPS clinician and site materials
  
FM-TIPS Participant Materials7/8/2026Implementation materialsFM-TIPS participant materials
  
FM-TIPS Data and Resource Sharing Checklist7/8/2026Data and Resource Sharing Checklist
  
July 7, 2026: AI, Ethics, and Pragmatic Trials: An Interview With Jeremy Sugarman and Adrian Hernandez7/7/2026News article
  
Closeout Data and Resource Sharing Checklist (pdf)7/2/2026HandoutAll NIH Collaboratory Trials are expected to share data and resources. The elements of a final data sharing package include the items listed in this checklist.
  
7/2/2026HandoutMS Word version of the Data and Resource Sharing Checklist. All NIH Collaboratory Demonstration Projects are expected to share data and resources.
  
PCT Statistical Analysis Plan Template7/2/2026TemplateThis PCT statistical analysis plan template, developed by the Biostatistics and Study Design Core, provides a starting point for research teams designing a new trial.
  
July 1, 2026: Mindfulness-Based Group Telehealth Visits Improve Chronic Low Back Pain in OPTIMUM Trial7/1/2026News article
  
OPTIMUM Main Outcome Paper6/29/2026Main outcome paperOPTIMUM Main Outcome Paper
  
June 29, 2026: NIH Collaboratory Biostatistics Expert Fan Li Receives ASPPH and COPSS Awards6/29/2026News article
  
Precision Engagement to Improve Population Health (Slides)6/26/2026Grand RoundsDr. Phillip D. Levy discusses “Precision Engagement to Improve Population Health.”
  
Precision Engagement to Improve Population Health (Video)6/26/2026Grand RoundsDr. Phillip D. Levy discusses “Precision Engagement to Improve Population Health.”
  
June 23, 2026: Updates From LungSMART: An Interview With Guilherme Del Fiol6/23/2026News article
  
June 18, 2026: Updates From the APA-SM Trial: An Interview With Jennifer Kawi6/18/2026News article
  
June 16, 2026: LungSMART Team Uses Bilingual Formative Evaluation to Hone Study’s Digital Health Content6/16/2026News article
  
June 15, 2026: Study Design Paper Published for APA-SM6/15/2026News article
  
Fluvoxamine and Metformin for Long COVID Fatigue - REVIVE-TOGETHER: An Adaptive Randomized Placebo-Controlled Trial6/12/2026Grand RoundsDr. Jamie Forrest discusses fluvoxamine and metformin use for Long COVID fatigue in the REVIVE-TOGETHER trial.
  
Fluvoxamine and Metformin for Long COVID Fatigue - REVIVE-TOGETHER: An Adaptive Randomized Placebo-Controlled Trial6/12/2026Grand RoundsDr. Jamie Forrest discusses fluvoxamine and metformin use for Long COVID fatigue in the REVIVE-TOGETHER trial.
  
June 11, 2026: Harnessing Qualitative Methods in Pragmatic Trials: An Interview With Emily O’Brien and David Chambers6/11/2026News article
  
June 9, 2026: Updates From the CARNATION Trial: An Interview With Lynn DeBar and Nicole Cook6/9/2026News article
  
APA-SM Study Design Paper6/8/2026Study design paperAPA-SM Study Design Paper
  
Barriers and facilitators for equitable clinical research among pragmatic trialists: A qualitative study6/8/2026Journal articlePublication from the Community Health Improvement Core
  
Bringing Context and Clarity to Clinical Trial Research for Clinician and Public Health Audiences: JAMA+ Trials (Slides)6/5/2026Grand RoundsDrs. Alison Huang and Derek Angus discuss “Bringing Context and Clarity to Clinical Trial Research for Clinician and Public Health Audiences: JAMA+ Trials.”
  
Bringing Context and Clarity to Clinical Trial Research for Clinician and Public Health Audiences: JAMA+ Trials (Video)6/5/2026Grand RoundsDrs. Alison Huang and Derek Angus discuss “Bringing Context and Clarity to Clinical Trial Research for Clinician and Public Health Audiences: JAMA+ Trials.”
  
June 2, 2026: Highlights From the FM-TIPS Trial: An Interview With Kathleen Sluka6/2/2026News article
  
Mobile Telemedicine for Treating Chronic Hepatitis C Among Rural People Who Inject Drugs: A Randomized Clinical Trial5/29/2026Grand RoundsDr. Thomas J. Stopka discusses “Mobile Telemedicine for Treating Chronic Hepatitis C Among Rural People Who Inject Drugs: A Randomized Clinical Trial.”
  
Mobile Telemedicine for Treating Chronic Hepatitis C Among Rural People Who Inject Drugs: A Randomized Clinical Trial5/29/2026Grand RoundsDr. Thomas J. Stopka discusses “Mobile Telemedicine for Treating Chronic Hepatitis C Among Rural People Who Inject Drugs: A Randomized Clinical Trial.”
  
May 28, 2026: Study Design Paper Published for AIM-CP5/28/2026News article
  
AIM-CP Study Design Paper5/27/2026Study design paperAIM-CP Study Design Paper
  
Mixed-method formative evaluation and cultural adaptation of digital health communication content and delivery promoting lung cancer screening shared decision-making5/27/2026Journal articlePublication from LungSMART
  
May 20, 2026: This Week’s IMPACT Collaboratory Grand Rounds Features Stephanie Morain on ePCTs and Health Systems’ Ethical Obligations5/20/2026News article
  
SCT Workshop 2026 Bios5/17/2026Participant ListBios for the 2026 SCT Workshop in Phoenix, AZ
  
SCT Workshop 2026 Case Study - AIM-CP5/17/2026PresentationAIM-CP Case Study Presentation at the 2026 SCT workshop
  
Welcoming Remarks - SCT 2026 Workshop5/17/2026PresentationEmily O'Brien's welcoming remarks at the 2026 SCT workshop
  
Opportunities for Embedded Pragmatic Clinical Trials (ePCTs)5/17/2026PresentationWendy Weber's presentation on ePCTs at the 2026 SCT workshop
  
SCT Workshop 2026 Case Study - Chat 4 Heart Health5/17/2026PresentationCase study presentation for Chat 4 Heart Health at the 2026 SCT workshop.
  
Engaging and Aligning With Partners - SCT Workshop 20265/17/2026PresentationEmily O'Brien's presentation on engaging partners at the 2026 SCT Workshop
  
ePCT Design5/17/2026PresentationPatrick Heagerty's presentation on ePCT design at the 2026 SCT workshop
  
Innovating Methods in ePCTs5/17/2026PresentationAngelo Volandes' presentation on innovative methods in ePCTs at the 2026 SCT workshop
  
ePCTs in Context panel - SCT Workshop 20265/17/2026PresentationEmily O'Brien's panel presentations at the 2026 SCT workshop
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