Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

  
  
  
  
  
  
NIH Pragmatic Trials Collaboratory Program Overview Handout1/31/2025HandoutThis handout gives an overview of the NIH Pragmatic Trials Collaboratory.
  
NIH Pragmatic Trials Collaboratory Program Accomplishments1/31/2025HandoutThis handout summarizes the accomplishments of the NIH Pragmatic Trials Collaboratory.
  
NIH Pragmatic Trials Collaboratory Program Impact Slides1/31/2025PresentationThis slide deck provides information about the impact of the NIH Pragmatic Trials Collaboratory.
  
Living Textbook Handout1/31/2025HandoutThis handout gives an overview of the Living Textbook of Pragmatic Clinical Trials.
  
Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned1/31/2025Grand RoundsDrs. Skolasky and McLaughlin discuss “Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned.”
  
Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned1/31/2025Grand RoundsDrs. Skolasky and McLaughlin discuss “Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned.”
  
NIH Collaboratory Program Overview Slides1/30/2025PresentationA presentation of the NIH Collaboratory’s goals, organizational structure, and trials.
  
January 29, 2025: Early Lessons From ARBOR-Telehealth, an NIH Collaboratory Trial, in This Week’s PCT Grand Rounds1/29/2025News article
  
NIH Pragmatic Trials Collaboratory Publications Process Handout1/27/2025PolicyThis document shows the NIH Collaboratory publications and presentations review process.
  
January 27, 2025: Study Snapshot and Updated Ethics Documentation Available for TAICHIKNEE1/27/2025News article
  
ARBOR-Telehealth Study Snapshot1/27/2025HandoutStudy snapshot of the ARBOR-Telehealth trial
  
AIM-CP Ethics and Regulatory Follow-up1/27/2025Ethics and regulatory documentationThis document contains the updated meeting minutes for the AIM-CP trial.
  
The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths 1/24/2025Grand RoundsDr. Jeffrey H. Samet discusses “The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths.”
  
The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths 1/24/2025Grand RoundsDr. Jeffrey H. Samet discusses “The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths.”
  
January 21, 2025: In PRIM-ER Trial, Palliative Care Training in Emergency Departments Did Not Reduce Hospital Admissions1/21/2025News article
  
TAICHIKNEE Ethics and Regulatory Follow-up1/17/2025Ethics and regulatory documentationThis document contains the updated meeting minutes for the TAICHIKNEE trial.
  
"Design for Diversity: Designing Studies for Representativeness and Generalizability."1/17/2025Grand RoundsDr. Lindsell discusses "Design for Diversity: Designing Studies for Representativeness and Generalizability."
  
"Design for Diversity: Designing Studies for Representativeness and Generalizability."1/17/2025Grand RoundsDr. Lindsell discusses "Design for Diversity: Designing Studies for Representativeness and Generalizability."
  
PRIM-ER Main Outcome Paper1/15/2025Main outcome paperPRIM-ER Main Outcome Paper
  
NIH Pragmatic Trials Collaboratory Publications Policy1/14/2025PolicyThis document describes the NIH Pragmatic Trials Collaboratory publications and presentations policy.
  
January 14, 2025: Ethics Consultation Documents Now Available for APA-SM Trial1/14/2025News article
  
APA-SM Ethics and Regulatory Discussion1/13/2025Ethics and regulatory documentationThis document contains the meeting minutes and supplementary materials for the APA-SM trial.
  
January 13, 2024: STEP-2 Trial of Cervical Cancer Screening Interventions Joins the NIH Collaboratory1/13/2025News article
  
FM-TIPS Community Engagement Methods for Recruitment1/10/2025Grand RoundsDrs. Heather Schacht Reisinger and Dana Dailey discuss FM-TIPS Community Engagement Methods for Recruitment.
  
FM-TIPS Community Engagement Methods for Recruitment1/10/2025Grand RoundsDrs. Heather Schacht Reisinger and Dana Dailey discuss FM-TIPS Community Engagement Methods for Recruitment.
  
January 8, 2025: In This Week’s PCT Grand Rounds, Community Engagement Methods in the FM-TIPS Trial1/8/2025News article
  
Onboarding Meeting January 2025: Agenda1/8/2025AgendaAgenda for the Jan. 2025 Collaboratory Virtual Onboarding Meeting
  
Onboarding Meeting January 2025 - Participant List1/8/2025Participant ListParticipant list for the Jan. 2025 Collaboratory Virtual Onboarding Meeting
  
Onboarding Meeting January 2025 - Collaboratory Overview & Cooperative Agreement1/8/2025PresentationWendy Weber provides an overview of the Collaboratory and a cooperative agreement at the Jan. 2025 Onboarding Meeting.
  
Onboarding Meeting January 2025 - CC Overview1/8/2025PresentationAdrian Hernandez provides an overview of the CC at the Jan. 2025 Onboarding Meeting
  
Onboarding Meeting Jan. 2025 - Patient-Centered Outcomes Intro1/8/2025PresentationEmily O'Brien and Christy Zigler provide an overview of the PCO Core at the Jan. 2025 Onboarding Meeting
  
Onboarding Meeting Jan 2025 - HCS Interactions Core Intro1/8/2025PresentationGreg Simon provides an overview of the HCS Core at the Jan. 2025 Onboarding Meeting
  
Onboarding Meeting Jan 2025 - Ethics and Regulatory Core Intro1/8/2025PresentationPearl O'Rourke and Stephanie Morain provide an intro to the Ethics and Regulatory Core at the Jan. 2025 Onboarding Meeting.
  
Onboarding Meeting Jan 2025 - Health Equity Core Intro1/8/2025PresentationRosa Gonzalez-Guarda and Cherise Harrington provide an overview of the Health Equity Core at the Jan. 2025 Onboarding Meeting
  
Onboarding Meeting Jan 2025 - Implementation Sci Core Intro1/8/2025PresentationDevon Check and Hayden Bosworth provide an overview of the Implementation Science Core at the Jan. 2025 Onboarding Meeting.
  
Onboarding Meeting January 2025 - EHR Core Intro1/8/2025Keith Marsolo and Rachel Richesson provide an overview of the EHR Core at the Jan. 2025 Onboarding Meeting.
  
Onboarding Meeting Jan 2025 - Biostatistics and Study Design Intro1/8/2025PresentationPatrick Heagerty and Liz Turner provide an overview of the Biostatistics and Study Design Core at the Jan. 2025 Onboarding Meeting.
  
Onboarding Meeting January - New UG3 NIH Collaboratory Trial Overview1/8/2025PresentationRachel Winer, Amanda Petrik, and Jasmin Tiro provide an overview of the new NIH Collaboratory Trial: STEP-2
  
January 6, 2025: Fritz and Rhon to Present Research Strategies for Pain Management in the Military Health System1/6/2025News article
  
Jan2025 Onboarding Mtg eBinder1/6/2025
  
TAICHIKNEE Study Snapshot1/6/2025HandoutStudy snapshot of the TAICHIKNEE trial
  
AIM-CP Study Snapshot12/20/2024HandoutStudy snapshot of the AIM-CP trial
  
RAMP Ethics and Regulatory Follow-up12/18/2024Ethics and regulatory documentationThis document contains the updated meeting minutes for the RAMP trial
  
AcademyHealth D&I Workshop 2024 Agenda12/17/2024HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination & Implementation in Embedded Pragmatic Trials: Getting the Timing Right in Real-World Research," at AcademyHealth's 17th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2024 Participant Guide12/17/2024HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination & Implementation in Embedded Pragmatic Trials: Getting the Timing Right in Real-World Research," at AcademyHealth's 17th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2024 Program Overview12/17/2024HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination & Implementation in Embedded Pragmatic Trials: Getting the Timing Right in Real-World Research," at AcademyHealth's 17th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2024 Speaker Bios12/17/2024HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination & Implementation in Embedded Pragmatic Trials: Getting the Timing Right in Real-World Research," at AcademyHealth's 17th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2024 - AIM-CP12/17/2024HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination & Implementation in Embedded Pragmatic Trials: Getting the Timing Right in Real-World Research," at AcademyHealth's 17th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2024 - BeatPain Utah12/17/2024HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination & Implementation in Embedded Pragmatic Trials: Getting the Timing Right in Real-World Research," at AcademyHealth's 17th Annual Dissemination and Implementation Conference.
  
AcademyHealth D&I Workshop 2024 - Chat 4 Heart Health12/17/2024HandoutThe NIH Pragmatic Trials Collaboratory hosted a workshop, "Dissemination & Implementation in Embedded Pragmatic Trials: Getting the Timing Right in Real-World Research," at AcademyHealth's 17th Annual Dissemination and Implementation Conference.
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