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Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

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September 16, 2024: Researchers Examine Feasibility of Enhanced TSOS Intervention for Trauma Survivors in Australia9/16/2024News article
  
September 12, 2024: NIH Collaboratory Biostatisticians Evaluate Analytic Models for Individually Randomized Group Treatment Trials9/12/2024News article
  
Conventional, Complementary, and Integrative Pain Therapies in a Military Population with Chronic Musculoskeletal Pain: Results of a Pragmatic Clinical Trial Using SMART Design9/6/2024Grand RoundsDrs. Ardith Z. Doorenbos and Diane M. Flynn discuss Conventional, Complementary, and Integrative Pain Therapies in a Military Population With Chronic Musculoskeletal Pain: Results of a Pragmatic Clinical Trial Using SMART Design.
  
Conventional, Complementary, and Integrative Pain Therapies in a Military Population with Chronic Musculoskeletal Pain: Results of a Pragmatic Clinical Trial Using SMART Design9/6/2024Grand RoundsDrs. Ardith Z. Doorenbos and Diane M. Flynn discuss Conventional, Complementary, and Integrative Pain Therapies in a Military Population With Chronic Musculoskeletal Pain: Results of a Pragmatic Clinical Trial Using SMART Design.
  
Evaluating analytic models for individually randomized group treatment trials with complex clustering in nested and crossed designs9/3/2024Journal articlePublication from the Biostatistics and Study Design Core
  
August 26, 2024: iPATH Trial Aims to Improve Diabetes Care in Community Health Centers8/26/2024News article
  
Improving Quality of Life in COPD and Heart Failure: Unpacking a Successful Multicomponent Virtual Team Intervention8/23/2024Grand RoundsDrs. David B. Bekelman and Lyndsay DeGroot discuss “Improving Quality of Life in COPD and Heart Failure: Unpacking a Successful Multicomponent Virtual Team Intervention.”
  
Improving Quality of Life in COPD and Heart Failure: Unpacking a Successful Multicomponent Virtual Team Intervention8/23/2024Grand RoundsDrs. David B. Bekelman and Lyndsay DeGroot discuss “Improving Quality of Life in COPD and Heart Failure: Unpacking a Successful Multicomponent Virtual Team Intervention.”
  
August 19, 2024: Ethics Core and Biostatistics Core Guide Newest Trials Through Planning Phase8/19/2024News article
  
Methodological Insights and Lessons Learned from Conducting a Pragmatic Randomized Trial on Surgical Face Masks8/16/2024Grand RoundsDr. Runar Solberg discusses methodological insights and lessons learned from conducting a pragmatic randomized trial on surgical face masks.
  
Methodological Insights and Lessons Learned from Conducting a Pragmatic Randomized Trial on Surgical Face Masks8/16/2024Grand RoundsDr. Runar Solberg discusses methodological insights and lessons learned from conducting a pragmatic randomized trial on surgical face masks.
  
August 13, 2024: EHR Core and Patient-Centered Outcomes Core Reflect on Challenges in Pragmatic Trials8/13/2024News article
  
August 12, 2024: I CAN DO Surgical ACP Seeks to Open the Door to Team-Based Surgical Care8/12/2024News article
  
Does starting buprenorphine prevent suicidal behavior: What trial should we emulate?8/9/2024Grand RoundsDr. Gregory Simon discusses whether starting buprenorphine prevents suicidal behavior and what trials we should emulate.
  
Does starting buprenorphine prevent suicidal behavior: What trial should we emulate?8/9/2024Grand RoundsDr. Gregory Simon discusses whether starting buprenorphine prevents suicidal behavior and what trials we should emulate.
  
August 5, 2024: NIH Collaboratory Leaders Reflect on Healthcare System and Patient Engagement Challenges and Lessons Learned8/5/2024News article
  
Precision Health to Population Health: Opportunities and Challenges for Gene Editing Therapies8/2/2024Grand RoundsDr. Adrian Hernandez discusses Precision Health to Population Health: Opportunities and Challenges for Gene Editing Therapies.
  
Precision Health to Population Health: Opportunities and Challenges for Gene Editing Therapies8/2/2024Grand RoundsDr. Adrian Hernandez discusses Precision Health to Population Health: Opportunities and Challenges for Gene Editing Therapies.
  
Stepped collaborative care for pain and posttraumatic stress disorder after major trauma: a randomized controlled feasibility trial8/1/2024Journal articlePublication from the TSOS trial
  
July 29, 2024: MOMs Chat & Care Study Aims to Address Crisis of Black Maternal Morbidity7/29/2024News article
  
Grand Rounds July 26, 2024: Interventions for Optimization of Guideline-Directed Medical Therapy (Gregg C. Fonarow, MD)7/26/2024Grand RoundsDr. Gregg C. Fonarow discusses interventions for optimizing guideline-directed medical therapy.
  
Interventions for Optimization of Guideline-Directed Medical Therapy7/26/2024Grand RoundsDr. Gregg C. Fonarow discusses interventions for optimizing guideline-directed medical therapy.
  
July 23, 2024: Article From Ethics and Regulatory Core Highlights Key Challenges for Pragmatic Trials7/23/2024News article
  
Pragmatic Trials of Branded Pharmaceuticals: Challenges and Opportunities7/19/2024Grand RoundsDrs. Brendan M. Everett and Deborah J. Wexler discuss “Pragmatic Trials of Branded Pharmaceuticals: Challenges and Opportunities.”
  
Pragmatic Trials of Branded Pharmaceuticals: Challenges and Opportunities7/19/2024Grand RoundsDrs. Deborah J. Wexler and Brendan M. Everett discuss “Pragmatic Trials of Branded Pharmaceuticals: Challenges and Opportunities.”
  
July 18, 2024: Latest Podcast Features Pearl O’Rourke and Stephanie Morain on Waiver of Consent7/18/2024News article
  
Recurring and emerging ethical issues in pragmatic clinical trials7/16/2024Journal articlePublication from the Ethics and Regulatory Core
  
2024 NIH Workshop Keynote Bertagnoli7/16/2024PresentationBertagnoli's Keynote Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Intro Session 3 Marsolo Panel7/16/2024PresentationMarsolo's panel intro slides at the NIH 2024 Workshop
  
2024 NIH Workshop Session 3 Wick7/16/2024PresentationWick Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 3 Almond7/16/2024PresentationAlmond Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 3 Crofford7/16/2024PresentationCrofford Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Intro Session 4 Gonzalez-Guarda Panel 7/16/2024PresentationGonzalez-Guarda's panel intro slides at the NIH 2024 Workshop
  
2024 NIH Workshop Session 3 Burgess7/16/2024PresentationBurgess Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 4 Vasilevskis7/16/2024PresentationVasilevskis Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 4 Coronado7/16/2024PresentationCoronado Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Intro Session 5 Hernandez Panel7/16/2024PresentationHernandez's panel intro slides at the NIH 2024 Workshop
  
2024 NIH Workshop Session 5 Hartman7/16/2024PresentationHartman's Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 5 Geeta7/16/2024PresentationGeeta's Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 5 ORourke7/16/2024PresentationORourke's Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 5 Marsolo7/16/2024PresentationMarsolo's Panel Presentation at the 2024 NIH Workshop
  
July 15, 2024: Chat 4 Heart Health Transitions to Implementation Phase7/15/2024News article
  
2024 NIH Workshop Intro Session 1 Weinfurt Panel7/15/2024PresentationWeinfurt's panel intro slides at the NIH 2024 Workshop
  
2024 NIH Workshop Session 1 McLaughlin7/15/2024PresentationMcLaughlin Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 1 Patel7/15/2024PresentationPatel Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 1 Cheville7/15/2024PresentationCheville Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 1 Simon7/15/2024PresentationSimon Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Intro Session 2 Simon Panel7/15/2024PresentationSimon's panel intro slides at the NIH 2024 Workshop
  
2024 NIH Workshop Session 2 Morone7/15/2024PresentationMorone Panel Presentation at the 2024 NIH Workshop
  
2024 NIH Workshop Session 2 Fritz7/15/2024PresentationFritz Panel Presentation at the 2024 NIH Workshop
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