Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

  
  
  
  
  
  
March 11, 2025: Study Design Paper Published for MOMs Chat & Care Study3/11/2025News article
  
A Trial of a “Kidney Action Team” for Hospitalized Patients with Acute Kidney Injury3/7/2025Grand RoundsDr. F. Perry Wilson discusses a trial of a “Kidney Action Team” for hospitalized patients with acute kidney injury.
  
A Trial of a “Kidney Action Team” for Hospitalized Patients with Acute Kidney Injury3/7/2025Grand RoundsDr. F. Perry Wilson discusses a trial of a “Kidney Action Team” for hospitalized patients with acute kidney injury.
  
March 4, 2025: PRIM-ER Team Develops Innovative Statistical Techniques for Stepped-Wedge Trials3/4/2025News article
  
Bayesian hierarchical penalized spline models for immediate and time-varying intervention effects in stepped wedge cluster randomized trials2/28/2025Journal articlePublication from PRIM-ER
  
Behavioral Economic and Staffing Strategies To Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU)2/28/2025Grand RoundsDrs. Eduard Vasilevskis and Michele C. Balas discuss “Behavioral Economic and Staffing Strategies to Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU).”
  
Behavioral Economic and Staffing Strategies to Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU)2/28/2025Grand RoundsDrs. Eduard Vasilevskis and Michele C. Balas discuss “Behavioral Economic and Staffing Strategies to Increase Adoption of the ABCDEF Bundle in the Intensive Care Unit (BEST-ICU).”
  
Monitoring in pragmatic trials lessons from the NIH Pragmatic Trials Collaboratory2/25/2025Journal articlePublication from the Coordinating Center
  
February 24, 2025: Study Snapshots and Updated Ethics Documentation Available for 3 NIH HEAL Initiative–Supported Trials in Rural Populations2/24/2025News article
  
RAMP Study Snapshot2/21/2025HandoutStudy snapshot of the RAMP trial
  
Texting for Behavior Change: Lessons Learned Across Two Interventions to Improve Chronic Care Management2/21/2025Grand RoundsDrs. Michael Ho and Sheana Bull discuss “Texting for Behavior Change: Lessons Learned Across Two Interventions to Improve Chronic Care Management.”
  
Texting for Behavior Change: Lessons Learned Across Two Interventions to Improve Chronic Care Management2/21/2025Grand RoundsDrs. Michael Ho and Sheana Bull discuss “Texting for Behavior Change: Lessons Learned Across Two Interventions to Improve Chronic Care Management.”
  
MOMs Chat & Care Study Design Paper2/21/2025Study design paperMOMs Chat & Care Study Design Paper
  
ICD-Pieces Study Snapshot2/20/2025HandoutStudy snapshot of the ICD-Pieces trial
  
February 19, 2025: Texting for Behavior Change to Improve Chronic Care Management, in This Week’s PCT Grand Rounds2/19/2025News article
  
February 12, 2025: Results of ACP PEACE, an NIH Collaboratory Trial, in This Week’s PCT Grand Rounds2/12/2025News article
  
Improving Symptom Control in Pediatric Cancer Patients with SSPedi and SPARK2/7/2025Grand RoundsDr. Lillian Sung discusses improving symptom control in pediatric cancer patients with SSPedi and SPARK.
  
Improving Symptom Control in Pediatric Cancer Patients with SSPedi and SPARK2/7/2025Grand RoundsDr. Lillian Sung discusses improving symptom control in pediatric cancer patients with SSPedi and SPARK.
  
NIH Pragmatic Trials Collaboratory Program Overview Handout1/31/2025HandoutThis handout gives an overview of the NIH Pragmatic Trials Collaboratory.
  
NIH Pragmatic Trials Collaboratory Program Accomplishments1/31/2025HandoutThis handout summarizes the accomplishments of the NIH Pragmatic Trials Collaboratory.
  
NIH Pragmatic Trials Collaboratory Program Impact Slides1/31/2025PresentationThis slide deck provides information about the impact of the NIH Pragmatic Trials Collaboratory.
  
Living Textbook Handout1/31/2025HandoutThis handout gives an overview of the Living Textbook of Pragmatic Clinical Trials.
  
Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned1/31/2025Grand RoundsDrs. Skolasky and McLaughlin discuss “Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned.”
  
Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned1/31/2025Grand RoundsDrs. Skolasky and McLaughlin discuss “Advancing Rural Back Pain Outcomes Using Rehabilitation Telehealth (ARBOR-Telehealth): Early Progress and Lessons Learned.”
  
Acute care use and prognosis in older adults presenting to the emergency department1/31/2025Journal articlePublication from the PRIM-ER trial
  
NIH Collaboratory Program Overview Slides1/30/2025PresentationA presentation of the NIH Collaboratory’s goals, organizational structure, and trials.
  
January 29, 2025: Early Lessons From ARBOR-Telehealth, an NIH Collaboratory Trial, in This Week’s PCT Grand Rounds1/29/2025News article
  
NIH Pragmatic Trials Collaboratory Publications Process Handout1/27/2025PolicyThis document shows the NIH Collaboratory publications and presentations review process.
  
January 27, 2025: Study Snapshot and Updated Ethics Documentation Available for TAICHIKNEE1/27/2025News article
  
ARBOR-Telehealth Study Snapshot1/27/2025HandoutStudy snapshot of the ARBOR-Telehealth trial
  
AIM-CP Ethics and Regulatory Follow-up1/27/2025Ethics and regulatory documentationThis document contains the updated meeting minutes for the AIM-CP trial.
  
NIH Collaboratory Communication Channels1/24/2025HandoutGraphic depiction of the communications channels in the NIH Health Care Systems Research Collaboratory Program
  
The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths 1/24/2025Grand RoundsDr. Jeffrey H. Samet discusses “The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths.”
  
The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths 1/24/2025Grand RoundsDr. Jeffrey H. Samet discusses “The HEALing Communities Study – 10 Million People, 67 Communities: A Community-Based Cluster Randomized Trial to Reduce Opioid Overdose Deaths.”
  
January 21, 2025: In PRIM-ER Trial, Palliative Care Training in Emergency Departments Did Not Reduce Hospital Admissions1/21/2025News article
  
TAICHIKNEE Ethics and Regulatory Follow-up1/17/2025Ethics and regulatory documentationThis document contains the updated meeting minutes for the TAICHIKNEE trial.
  
"Design for Diversity: Designing Studies for Representativeness and Generalizability."1/17/2025Grand RoundsDr. Lindsell discusses "Design for Diversity: Designing Studies for Representativeness and Generalizability."
  
"Design for Diversity: Designing Studies for Representativeness and Generalizability."1/17/2025Grand RoundsDr. Lindsell discusses "Design for Diversity: Designing Studies for Representativeness and Generalizability."
  
PRIM-ER Main Outcome Paper1/15/2025Main outcome paperPRIM-ER Main Outcome Paper
  
NIH Pragmatic Trials Collaboratory Publications Policy1/14/2025PolicyThis document describes the NIH Pragmatic Trials Collaboratory publications and presentations policy.
  
January 14, 2025: Ethics Consultation Documents Now Available for APA-SM Trial1/14/2025News article
  
APA-SM Ethics and Regulatory Discussion1/13/2025Ethics and regulatory documentationThis document contains the meeting minutes and supplementary materials for the APA-SM trial.
  
January 13, 2024: STEP-2 Trial of Cervical Cancer Screening Interventions Joins the NIH Collaboratory1/13/2025News article
  
FM-TIPS Community Engagement Methods for Recruitment1/10/2025Grand RoundsDrs. Heather Schacht Reisinger and Dana Dailey discuss FM-TIPS Community Engagement Methods for Recruitment.
  
FM-TIPS Community Engagement Methods for Recruitment1/10/2025Grand RoundsDrs. Heather Schacht Reisinger and Dana Dailey discuss FM-TIPS Community Engagement Methods for Recruitment.
  
January 8, 2025: In This Week’s PCT Grand Rounds, Community Engagement Methods in the FM-TIPS Trial1/8/2025News article
  
Onboarding Meeting January 2025: Agenda1/8/2025AgendaAgenda for the Jan. 2025 Collaboratory Virtual Onboarding Meeting
  
Onboarding Meeting January 2025 - Participant List1/8/2025Participant ListParticipant list for the Jan. 2025 Collaboratory Virtual Onboarding Meeting
  
Onboarding Meeting January 2025 - Collaboratory Overview & Cooperative Agreement1/8/2025PresentationWendy Weber provides an overview of the Collaboratory and a cooperative agreement at the Jan. 2025 Onboarding Meeting.
  
Onboarding Meeting January 2025 - CC Overview1/8/2025PresentationAdrian Hernandez provides an overview of the CC at the Jan. 2025 Onboarding Meeting
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