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Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

Name
  
Title
  
Resource Date
  
Resource Type
  
Resource_Description
  
  
I CAN DO Surgical ACP Ethics and Regulatory Discussion12/4/2023Ethics and regulatory documentationThis document contains the meeting minutes and supplementary materials for the I CAN DO Surgical ACP Demonstration Project
  
Guidelines for Design and Analysis of Stepped-Wedge Trials12/1/2023Grand RoundsDr. James P. Hughes discusses guidelines for design and analysis of stepped-wedge trials.
  
Guidelines for Design and Analysis of Stepped-Wedge Trials12/1/2023Grand RoundsDr. James P. Hughes discusses guidelines for design and analysis of stepped-wedge trials.
  
ePCT Factsheet11/22/2023HandoutInformation sheet about the NIH Collaboratory and pragmatic clinical trials
  
Nudge Study Snapshot11/20/2023HandoutStudy snapshot of the Nudge Demonstration Project
  
ACP PEACE Study Snapshot11/20/2023HandoutSnapshot of the ACP PEACE Demonstration Project
  
BeatPain Utah Study Snapshot11/20/2023HandoutStudy snapshot of the BeatPain Utah Demonstration Project
  
GGC4H Study Snapshot11/17/2023HandoutSnapshot of the GGC4H Demonstration Project
  
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study11/17/2023Grand RoundsDrs. Michael Ho and Sheana Bull discuss Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study.
  
Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study11/17/2023Grand RoundsDrs. Michael Ho and Sheana Bull discuss Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications: Results from the Nudge Study.
  
Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial11/13/2023PodcastDr. Harlan M. Krumholz discusses lessons from the digital, decentralized and democratized Yale PaxLC Trial.
  
ABATE Infection Study Snapshot11/7/2023HandoutCloseout snapshot of the ABATE Infection Demonstration Project
  
HiLo Study Snapshot11/7/2023HandoutStudy snapshot of the HiLo Demonstration Project
  
PROVEN Study Snapshot11/7/2023HandoutCloseout snapshot of the PROVEN Demonstration Project
  
FM-TIPS Study Snapshot11/7/2023HandoutStudy snapshot of the FM TIPS Demonstration Project
  
BackInAction Study Snapshot11/7/2023HandoutStudy snapshot of the BackInAction Demonstration Project
  
NOHARM Study Snapshot11/7/2023HandoutStudy snapshot of the NOHARM Demonstration Project
  
INSPIRE Study Snapshot11/7/2023HandoutStudy snapshot of the INSPIRE Demonstration Project
  
IMPACt-LBP Study Snapshot11/7/2023HandoutSnapshot of the IMPACt-LBP Demonstration Project
  
The Perils and Pitfalls of Complex Clustering in Pragmatic Trials11/3/2023Grand RoundsDr. Jonathan Moyer discusses the perils and pitfalls of complex clustering in pragmatic trials.
  
The Perils and Pitfalls of Complex Clustering in Pragmatic Trials11/3/2023Grand RoundsDr. Jonathan Moyer discusses the perils and pitfalls of complex clustering in pragmatic trials.
  
Onboarding Meeting November 2023 - AIM-CP11/1/2023PresentationAIM-CP PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - ARBOR-Telehealth 11/1/2023PresentationARBOR-Telehealth PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - I CAN DO Surgical ACP11/1/2023PresentationI CAN DO Surgical ACP PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - iPATH11/1/2023PresentationiPATH PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - MOMs 11/1/2023PresentationMOMs PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - RAMP11/1/2023PresentationRAMP PIs present at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - CC Overview and Goals11/1/2023PresentationLesley Curtis provides an overview of the CC at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - Collaboratory Overview & Cooperative Agreement11/1/2023PresentationBeda Jean-Francois provides an overview of the Collaboratory and a cooperative agreement at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - Lessons Learned11/1/2023PresentationDemonstration Project PIs provide an overview of lessons learned at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - Program Policies and Guidance Documents11/1/2023PresentationPlatt and Uhlenbrauck present on program policies and guidance documents at the Nov. 2023 Onboarding Meeting.
  
Onboarding Meeting November 2023 - Agenda11/1/2023AgendaAgenda for the Nov. 2023 Collaboratory Virtual Onboarding Meeting
  
Onboarding Meeting November 2023 - Participant List11/1/2023Participant ListParticipant list for the Nov. 2023 Collaboratory Virtual Onboarding Meeting
  
October 31, 2023: NIH Pragmatic Trials Collaboratory Welcomes 5 New Demonstration Projects10/31/2023News article
  
NIH I Team Chart with POs and PSs10/30/2023HandoutThe NIH Implementation Team includes NIH staff who support individual Demonstration Projects.
  
Collaboratory 2023 Onboarding Mtg 2 eBinder_Final10/30/2023e-Binder for November 1, 2023 Onboarding Meeting
  
Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial10/27/2023Grand RoundsDr. Harlan M. Krumholz discusses lessons from the digital, decentralized and democratized Yale PaxLC Trial.
  
Digital, Decentralized and Democratized: Lessons From The Yale PaxLC Trial10/27/2023Grand RoundsDr. Harlan M. Krumholz discusses lessons from the digital, decentralized and democratized Yale PaxLC Trial.
  
What Are Common Pitfalls in Writing PCT Grant Applications?10/20/2023TranscriptDr. Wendy Weber discusses common pitfalls in writing PCT grant applications.
  
Is it Important to Explain the Definition of Pragmatic to Grant Reviewers?10/20/2023TranscriptDr. Wendy Weber discusses if it is important to explain the definition of pragmatic to grant reviewers.
  
What Are the “Must Dos” of Writing PCT Grant Applications?10/20/2023TranscriptDr. Wendy Weber discusses the "must dos" of writing PCT grant applications.
  
What Should I Avoid When Writing PCT Grant Applications?10/20/2023TranscriptDr. Wendy Weber discusses what to avoid when writing PCT grant applications.
  
What Are Some Success Strategies When Writing PCT Grant Applications?10/20/2023TranscriptDr. Wendy Weber discusses success strategies for writing PCT grant applications.
  
How Do You Design Trials That Are Fit for Purpose?10/20/2023TranscriptDr. Lesley Curtis discusses how to design trials that are fit for purpose.
  
What Are Pragmatic Clinical Trials?10/20/2023TranscriptDr. Lesley Curtis describes pragmatic clinical trials.
  
Why Should I Do a Pragmatic Trial?10/20/2023TranscriptDr. Lesley Curtis discusses reasons to conduct pragmatic clinical trials.
  
A National Initiative to Eliminate Hepatitis C in the United States – Why This Matters to Clinical Trialists10/20/2023Grand RoundsDrs. Rachael L. Fleurence and Joshua M. Sharfstein discuss a national initiative to eliminate Hepatitis C in the U.S.
  
A National Initiative to Eliminate Hepatitis C in the United States – Why This Matters to Clinical Trialists10/20/2023Grand RoundsDrs. Rachael L. Fleurence and Joshua M. Sharfstein discuss a national initiative to eliminate Hepatitis C in the U.S.
  
What Do Endpoints and Outcomes Look Like in Pragmatic Trials?10/19/2023TranscriptDr. Devon Check discusses endpoints and outcomes in pragmatic trials.
  
How Do Data Sources Inform the Choice of Endpoints and Outcomes in Pragmatic Trials?10/19/2023TranscriptDr. Devon Check discusses how data sources inform the choice of endpoints and outcomes in pragmatic trials.
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