Skip Ribbon Commands
Skip to main content
SharePoint

Home

​

Welcome to the Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials, compiled by the NIH Collaboratory Coordinating Center. For additional content and information about the NIH Collaboratory, visit www.rethinkingclinicaltrials.org.

NameUse SHIFT+ENTER to open the menu (new window).
  
TitleUse SHIFT+ENTER to open the menu (new window).
  
Resource DateUse SHIFT+ENTER to open the menu (new window).
  
Resource TypeUse SHIFT+ENTER to open the menu (new window).
  
Resource_DescriptionUse SHIFT+ENTER to open the menu (new window).
  
  
HERO-TOGETHER: Building Vaccine Confidence With Long-Term Outcomes Data1/8/2021Grand RoundsDr. O’Brien discusses the HERO-TOGETHER initiative that aims to understand how healthcare workers do after receiving a COVID-19 vaccination.
  
HERO-TOGETHER: Building Vaccine Confidence With Long-Term Outcomes Data1/8/2021Grand RoundsDr. O’Brien discusses the HERO-TOGETHER initiative that aims to understand how healthcare workers do after receiving a COVID-19 vaccination.
  
FM TIPS Study Snapshot1/7/2021HandoutStudy snapshot of the FM TIPS Demonstration Project
  
BackInAction Study Snapshot1/7/2021HandoutStudy snapshot of the BackInAction Demonstration Project
  
NOHARM Study Snapshot1/7/2021HandoutStudy snapshot of the NOHARM Demonstration Project
  
OPTIMUM Study Snapshot1/7/2021HandoutStudy snapshot of the OPTIMUM Demonstration Project
  
The SAMSON Trial: An N-of-1 Trial of Statin, Placebo, and No Treatment to Assess Patient Symptoms 12/18/2020Grand RoundsDr. Shun-Shin describes the design and results of the SAMSON trial that evaluated perceived side effects of statin medications.
  
The SAMSON Trial: An N-of-1 Trial of Statin, Placebo, and No Treatment to Assess Patient Symptoms 12/18/2020Grand RoundsDr. Shun-Shin describes the design and results of the SAMSON trial that evaluated perceived side effects of statin medications.
  
December 15, 2020: A Year of Results and New Insights From the NIH Collaboratory12/15/2020News articleNews article about NIH Collaboratory publications in 2020
  
PREVENTABLE: Starting a Pragmatic Trial in a Pandemic12/11/2020Grand RoundsDrs. Alexander and Jones describe the challenges of starting a trial during the COVID-19 pandemic.
  
PREVENTABLE: Starting a Pragmatic Trial in a Pandemic 12/11/2020Grand RoundsDrs. Alexander and Jones describe the challenges of starting a trial during the COVID-19 pandemic.
  
The Yale New Haven Health System as an Evidence Generation Ecosystem for Heart Failure12/4/2020Grand RoundsDr. Ahmad discusses studies evaluating data-driven methodologies for predicting clinical outcomes in patients with heart failure.
  
The Yale New Haven Health System as an Evidence Generation Ecosystem for Heart Failure12/4/2020Grand RoundsDr. Ahmad discusses studies evaluating data-driven methodologies for predicting clinical outcomes in patients with heart failure.
  
Drug Development in Kidney Disease: Proceedings from a Multi-Stakeholder Panel 11/20/2020Grand RoundsDr. Edmonston describes the landscape of drug development and clinical trials evaluating treatments for chronic kidney disease.
  
Drug Development in Kidney Disease: Proceedings from a Multi-Stakeholder Panel11/20/2020Grand RoundsDr. Edmonston describes the landscape of drug development and clinical trials evaluating treatments for chronic kidney disease.
  
Pragmatic and Explanatory Attitudes to RCTs: Using the PRECIS-2 Tool to Describe the Design of the MyTEMP Trial 11/13/2020Grand RoundsDrs. Zwarenstein, Al-Jaishi, and Garg discuss the differences between explanatory and pragmatic approaches to randomized controlled trials as illustrated by two contrasting trials.
  
Pragmatic and Explanatory Attitudes to RCTs: Using the PRECIS-2 Tool to Describe the Design of the MyTEMP Trial 11/13/2020Grand RoundsDrs. Zwarenstein, Al-Jaishi, and Garg discuss the differences between explanatory and pragmatic approaches to randomized controlled trials as illustrated by two contrasting trials.
  
Reduction in movement-evoked pain and fatigue during initial 30-minute TENS treatment predicts TENS responders in women with fibromyalgia11/11/2020Journal articlePublication from the FM TIPS Demonstration Project
  
PROVEN Closeout Snapshot11/10/2020HandoutCloseout snapshot of the PROVEN Demonstration Project
  
2020 PRISM Onboarding Meeting Agenda11/9/2020AgendaAgenda for the November 9, 2020 PRISM Onboarding meeting.
  
Program Overview Presentation at 2020 PRISM Onboarding Meeting11/9/2020PresentationDr. Meyers gives an overview of the Collaboratory at the 2020 PRISM Onboarding Meeting.
  
HEAL Cooperative Agreement Presentation at 2020 PRISM Onboarding Meeting11/9/2020PresentationDrs. Weber and Wandner give a presentation on the HEAL Cooperative Agreement at the 2020 PRISM Onboarding Meeting.
  
BeatPain Utah Presentation at 2020 PRISM Onboarding Meeting11/9/2020PresentationDr. Fritz presents on BeatPain Utah at the 2020 PRISM Onboarding Meeting.
  
HEAL Overview Presentation at the 2020 PRISM Onboarding Meeting11/9/2020PresentationDr. Baker gives a HEAL Overview at the 2020 PRISM Onboarding Meeting.
  
Participant List for 2020 PRISM Onboarding Meeting11/9/2020Participant ListList of participants for the 2020 PRISM Virtual Onboarding Meeting.
  
Impact of an advance care planning video intervention on care of short-stay nursing home patients11/7/2020Journal articlePublication from the PROVEN Demonstration Project
  
Appendectomy Versus Antibiotics for Appendicitis–Early Results from the CODA Trial 11/6/2020Grand RoundsDr. Flum discusses the CODA comparative effectiveness trial that compared two treatments for appendicitis.
  
Appendectomy Versus Antibiotics for Appendicitis–Early Results from the CODA Trial 11/6/2020Grand RoundsDr. Flum discusses the CODA comparative effectiveness trial that compared two treatments for appendicitis.
  
Lessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience11/6/2020PodcastDr. Boulware discusses the complexities of conducting virtual clinical trials during the COVID-19 pandemic.
  
Lessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience11/6/2020TranscriptDr. Boulware discusses the complexities of conducting virtual clinical trials during the COVID-19 pandemic.
  
November 5, 2020: NIH HEAL Initiative Common Data Elements Published in the Living Textbook11/5/2020News articleNews article about NIH HEAL common data elements
  
LIRE Closeout Snapshot11/5/2020HandoutCloseout snapshot of the LIRE Demonstration Project
  
November 3, 2020: Disseminating Trial Results: We Can Have Faster and Better11/3/2020News articleNews article about speedier dissemination of trail results.
  
November 2, 2020: PRIM-ER Pilot Study Identifies Keys to Implementation Success11/2/2020News articleNews article about PRIM-ER implementation publication.
  
Lessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience 10/30/2020Grand RoundsDr. Boulware describes how his study team was able to rapidly set up virtual clinical trials during the early days of the COVID-19 pandemic.
  
Lessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience 10/30/2020Grand RoundsDr. Boulware describes how his study team was able to rapidly set up virtual clinical trials during the early days of the COVID-19 pandemic.
  
Effectiveness and reach of the Primary Palliative Care for Emergency Medicine (PRIM-ER) Pilot Study: a qualitative analysis10/27/2020Journal articlePublication from the PRIM-ER Demonstration Project
  
Outpatient Clinical Decision Support – An Evidence-Based Implementation Framework 10/23/2020Grand RoundsDrs. Sperl-Hillen and O’Connor share lessons learned in the development of a clinical decision support system used in primary care visits.
  
Outpatient Clinical Decision Support – An Evidence-Based Implementation Framework 10/23/2020Grand RoundsDrs. Sperl-Hillen and O’Connor share lessons learned in the development of a clinical decision support system used in primary care visits.
  
October 22, 2020: TSOS Study Team Describes Impacts of a COVID-19 Surge on Delivery of Acute Care and Emergency Services10/22/2020News articleNews article describing impacts of COVID on TSOS.
  
Rapid ethnographic assessment of the COVID-19 pandemic April 2020 'surge' and its impact on service delivery in an acute care medical emergency department and trauma center10/20/2020Journal articlePublication from the TSOS Demonstration Project
  
Back to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative 10/16/2020Grand RoundsDrs. Zimmerman and Benjamin discuss the ABC Science Collaborative, which aims to unite science and schools for a data-driven solution to decision-making and implementation around mitigating COVID-19.
  
Back to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative 10/16/2020Grand RoundsDrs. Zimmerman and Benjamin discuss the ABC Science Collaborative, which aims to unite science and schools for a data-driven solution to decision-making and implementation around mitigating COVID-19.
  
October 12, 2020: NIH Collaboratory Welcomes 2 New PRISM Demonstration Projects to Address the Opioid Epidemic10/12/2020News articleThe Collaboratory announces 2 new PRISM Demonstration Projects.
  
Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo) (GR Slides 2020)10/9/2020Grand RoundsDr. Wolf presents an update on HiLo, an NIDDK-funded pragmatic trial testing which phosphate treatment target provides the best clinical outcomes for patients.
  
Pragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo) (GR Video 2020)10/9/2020Grand RoundsDr. Wolf presents an update on HiLo, an NIDDK-funded pragmatic trial testing which phosphate treatment target provides the best clinical outcomes for patients.
  
ACP PEACE Study Redesign (Details)10/7/2020Study design paperThis document describes changes to the ACP PEACE stepped-wedge study design to address effects caused by the onset of COVID-19.
  
October 7, 2020: A Year Into Implementation, HiLo Shares an Update and Lessons Learned10/7/2020News articleNews article about HiLo Grand Rounds.
  
October 6, 2020: Four PRISM Demonstration Projects Awarded Continuation from Planning to Implementation Phase10/6/2020News articleNews article about the PRISM projects being awarded from continuation to planning phase.
  
Driving Toward Health Impact: Our Journey and Path Forward10/2/2020Grand RoundsDr. Cook presents highlights of PCORI’s 2.0 strategic plan to accelerate the impact on health care and patient outcomes.
1 - 50Next