Skip Ribbon Commands
Skip to main content
SharePoint

KR Documents and Links to Content
Knowledge Repository Library

  
  
  
  
  
  
Optimized Learning While Doing: The REMAP-CAP Adaptive Platform Trial 5/15/2020Grand RoundsDr. Angus describes a global adaptive platform trial developed to determine and continuously update the optimal set of treatments for community-acquired pneumonia and other conditions.
  
Optimized Learning While Doing: The REMAP-CAP Adaptive Platform Trial5/15/2020Grand RoundsDr. Angus describes a global adaptive platform trial developed to determine and continuously update the optimal set of treatments for community-acquired pneumonia and other conditions.
  
Real World Evidence: Contemporary Experience and Future Directions5/8/2020Grand RoundsA panel of experts discuss current and future directions for generating real-world evidence (RWE) as illustrated by programs at the FDA and NIH.
  
Real World Evidence: Contemporary Experience and Future Directions5/8/2020Grand RoundsA panel of experts discuss current and future directions for generating real-world evidence (RWE) as illustrated by programs at the FDA and NIH.
  
Can the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem?5/1/2020Grand RoundsDr. Califf presents the keynote address for a special Grand Rounds webinar series on advances at the intersection of digital health, electronic health records, and pragmatic clinical trials.
  
Can the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem? 5/1/2020VideoDr. Califf presents the keynote address for a special Grand Rounds webinar series on advances at the intersection of digital health, electronic health records, and pragmatic clinical trials
  
Experiences and insights from the early US COVID-19 epicenter: a Rapid Assessment Procedure Informed Clinical Ethnography case series4/27/2020Journal articlePublication from the TSOS Demonstration Project
  
The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 4/24/2020Grand RoundsDr. Landray describes a coordinated approach to the rapid establishment of a platform for the RECOVERY randomized trial evaluating four medications to treat COVID-19 in hospitalized adult patients.
  
The RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 4/24/2020VideoDr. Landray describes a coordinated approach to the rapid establishment of a platform for the RECOVERY randomized trial evaluating four medications to treat COVID-19 in hospitalized adult patients.
  
ClinicalTrials.gov - Updates and Modernization4/23/2020PresentationSteering Committee Meeting (Virtual) – Strengthening Partnerships in the ePCT Ecosystem
  
FDA Real-World Evidence - Embedded RCTs4/23/2020PresentationSteering Committee Meeting (Virtual) – Strengthening Partnerships in the ePCT Ecosystem
  
Ecosystem Grid - Bird’s Eye View of Collaboratory Demonstration Projects4/23/2020PresentationSteering Committee Meeting (Virtual) – Strengthening Partnerships in the ePCT Ecosystem
  
Utilizing Text Message Technology in a Pragmatic Clinical Trial - The Experience of the Nudge Study4/23/2020PresentationSteering Committee Meeting (Virtual) – Novel Approaches from the Collaboratory
  
PROVEN - Novel Data Management and Integration Approaches4/23/2020PresentationSteering Committee Meeting (Virtual) – Novel Approaches from the Collaboratory
  
Reactions from the EHR Core – Nudge & PROVEN4/23/2020PresentationSteering Committee Meeting (Virtual) – Novel Approaches from the Collaboratory
  
Lumbar Imaging with Reporting of Epidemiology (LIRE) - Lessons Learned4/23/2020PresentationSteering Committee Meeting (Virtual) – 20:20 in 2020
  
Trauma Survivors Outcomes & Support (TSOS) - Progress, Barriers & Lessons Learned4/23/2020PresentationSteering Committee Meeting (Virtual) – 20:20 in 2020
  
ICD-Pieces – Lessons Learned4/23/2020PresentationSteering Committee Meeting (Virtual) – 20:20 in 2020
  
PROVEN – Lessons Learned4/23/2020PresentationSteering Committee Meeting (Virtual) – 20:20 in 2020
  
NIH Collaboratory Getting Pragmatic - Are We Stalled?4/22/2020PresentationSteering Committee Meeting (Virtual) Keynote
  
A Learning Health Care System - Are We Building One?4/22/2020PresentationSteering Committee Meeting (Virtual) Keynote
  
Complexities in ePCT Bioethics Ecosystem - Have We Overcome the Challenges?4/22/2020PresentationSteering Committee Meeting (Virtual) Keynote
  
The Mental Health Research Network - An NIMH Prototype of Learning Healthcare4/22/2020PresentationSteering Committee Meeting (Virtual) – The Current Landscape of ePCTs
  
Pragmatic Clinical Studies - PCORI Investigators’ Experience4/22/2020PresentationSteering Committee Meeting (Virtual) – The Current Landscape of ePCTs
  
The NIA IMPACT Collaboratory4/22/2020PresentationSteering Committee Meeting (Virtual) – The Current Landscape of ePCTs
  
Improving Cancer Symptom Management in Scalable Pragmatic Trials - Overview of the IMPACT Consortium4/22/2020PresentationSteering Committee Meeting (Virtual) – The Current Landscape of ePCTs
  
Steering Committee Meeting (Virtual) Agenda4/22/2020AgendaAgenda for the 2-day virtual Steering Committee meeting (April 22-23, 2020)
  
Steering Committee Meeting (Virtual) Participants List4/22/2020Participant ListAgenda for the 2-day virtual Steering Committee meeting (April 22-23, 2020)
  
Advances at the Intersection of Digital Health, Electronic Health Records and Pragmatic Clinical Trials: A Grand Rounds EHR Workshop Series4/20/2020Grand Rounds
  
Access to home and community health services for older adults with serious, life-limiting illness: a study protocol4/20/2020Journal articlePublication from the PRIM-ER Demonstration Project
  
The HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle Evidence4/17/2020Grand RoundsA panel discusses the HERO program, a new registry that unites healthcare workers across America in sharing their clinical and life experiences around COVID-19.
  
The HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle Evidence4/17/2020VideoA panel discusses the HERO program, a new registry that unites healthcare workers across America in sharing their clinical and life experiences around COVID-19.
  
Evidence from pragmatic trials — slouching toward a learning health system4/16/2020Journal articlePublication from the NIH Collaboratory Coordinating Center
  
Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial 4/10/2020Grand RoundsDr. Collins discusses a new randomized clinical trial evaluating hydroxychloroquine for hospitalized adult patients with COVID-19.
  
Hydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial4/10/2020VideoDr. Collins discusses a new randomized clinical trial evaluating hydroxychloroquine for hospitalized adult patients with COVID-19.
  
Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research 4/3/2020Grand RoundsA panel discusses the work of the INSPIRE consortium to address the urgent need for evidence amid the COVID-19 pandemic.
  
Innovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research 4/3/2020VideoA panel discusses the work of the INSPIRE consortium to address the urgent need for evidence amid the COVID-19 pandemic.
  
Engagement in Research for Pragmatic Clinical Trials3/30/2020Guidance documentThis document provides considerations for investigators designing and conducting PCTs as well as institutional review boards (IRBs) overseeing them.
  
Living Textbook Grand Rounds Series: Part 3-Tips for Putting Together a Successful PCT Grant Application 3/27/2020Grand RoundsDr. Weber presents best approaches to developing a successful grant application for embedded PCTs.
  
Living Textbook Grand Rounds Series: Part 3-Tips for Putting Together a Successful PCT Grant Application 3/27/2020VideoDr. Weber presents best approaches to developing a successful grant application for embedded PCTs.
  
Clinical Trials in the Time of COVID-19 3/20/2020Grand RoundsA Duke University panel discusses the impact of the COVID-19 outbreak on the conduct of clinical trials.
  
Design and Analysis of Embedded Pragmatic Clinical Trials Workshop Summary3/20/2020Meeting summaryThis document summarizes presentations from a 2019 NIH Collaboratory comprehensive workshop that explored statistical issues encountered with embedded pragmatic clinical trials (ePCTs).
  
Intraclass Correlation Coefficient Cheat Sheet3/16/2020HandoutAn introductory description of the intraclass correlation coefficient (ICC), a descriptive statistic that is important for the design and analysis of cluster-randomized trials
  
Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions 3/13/2020Grand RoundsDrs. Sharma and Granger discuss aspects of the regulatory guidance for evaluating the cardiovascular risk of new glucose-lowering treatments for type 2 diabetes.
  
Impact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions 3/13/2020VideoDrs. Sharma and Granger discuss aspects of the regulatory guidance for evaluating the cardiovascular risk of new glucose-lowering treatments for type 2 diabetes.
  
Using predictive analytics to improve pragmatic trial design3/10/2020Journal articlePublication from the SPOT Demonstration Project
  
Creating a Learning Health System Through Randomization 3/6/2020Grand RoundsDr. Horwitz describes methods for using randomization in health system quality improvement (QI) initiatives to promote a learning healthcare system.
  
Creating a Learning Health System Through Randomization 3/6/2020VideoDr. Horwitz describes methods for using randomization in health system quality improvement (QI) initiatives to promote a learning healthcare system.
  
LIRE Public Use Dataset and Data Dictionary3/5/2020Public use datasetLIRE Public Use Dataset and Data Dictionary
  
LIRE Computable Phenotypes3/5/2020Computable phenotypeLIRE Computable Phenotypes
1 - 50Next