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9/10/2021Grand RoundsBruce NealImperial College London; George Institute Australia; University of SydneyEffect of Salt Substitution on Cardiovascular Events and DeathDr. Neal shares the results from the SSaSS study on the effects of reduced-sodium, added-potassium salt substitute on stroke, cardiovascular events, and death.
  
9/10/2021Grand RoundsBruce NealGeorge Institute Australia; Imperial College London; University of SydneyEffect of Salt Substitution on Cardiovascular Events and DeathDr. Neal shares the results from the SSaSS study on the effects of reduced-sodium, added-potassium salt substitute on stroke, cardiovascular events, and death.
  
8/27/2021Grand RoundsBenjamin HibbertUniversity of OttawaMilrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trialDr. Hibbert shares the results from the CAPITAL DOREMI study and discusses the importance of randomized pragmatic clinical trials to generate quality data on therapeutics.
  
8/27/2021Grand RoundsBenjamin HibbertUniversity of OttawaMilrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial Dr. Hibbert shares the results from the CAPITAL DOREMI study and discusses the importance of randomized pragmatic clinical trials to generate quality data on therapeutics.
  
8/20/2021Grand RoundsEric LenzeWashington University in St. LouisFluvoxamine for early treatment of COVID-19: the STOP COVID clinical trialsDr. Eric Lenze discusses the STOP COVID trials, the latest research on Fluvoxamine for the early treatment of COVID-19.
  
8/20/2021Grand RoundsEric LenzeWashington University in St. LouisFluvoxamine for early treatment of COVID-19: the STOP COVID clinical trialsDr. Eric Lenze discusses the STOP COVID trials, the latest research on Fluvoxamine for the early treatment of COVID-19.
  
8/13/2021Grand RoundsDavey SmithUniversity of California, San DiegoGot anything for this cough? Outpatient Treatment Trials in the Time of COVIDDr. Smith discusses the history of proposed therapies for COVID-19 and how the Adaptive Platform Trial ACTIV -2 seeks to find a successful new therapy.
  
8/13/2021Grand RoundsDavey SmithUniversity of California, San DiegoGot anything for this cough? Outpatient Treatment Trials in the Time of COVIDDr. Smith discusses the history of proposed therapies for COVID-19 and how the Adaptive Platform Trial ACTIV -2 seeks to find a successful new therapy.
  
8/6/2021Grand RoundsEdward MillsMcMaster UniversityEarly Treatment of COVID-19 with Repurposed Therapies: The TOGETHER Adaptive Platform Trial Dr. Mills shares the latest data on Repurposed Therapies for COVID-19 and discusses the elements of successful Adaptive Platform Trials.
  
8/6/2021Grand RoundsEdward MillsMcMaster UniversityEarly Treatment of COVID-19 with Repurposed Therapies: The TOGETHER Adaptive Platform Trial Dr. Mills shares the latest data on Repurposed Therapies for COVID-19 and discusses the elements of successful Adaptive Platform Trials.
  
7/30/2021Grand RoundsNatalia Morone; George A. Mensah; Marie A. Bernard; Lesley CurtisNational Institute on Aging (NIA); NIH; National Heart, Lung, and Blood Institute (NHLBI); Duke University School of Medicine; Boston University School of MedicineInclusion of Diverse Participants in Pragmatic Clinical Trials: Diversity in the PCT Ecosystem – How Do We Develop a Pipeline of Diverse Investigators and Leaders in PCTs?Dr. Curtis moderates a discussion with Drs. Bernard, Mensah, and Morone about initiatives and best practices to address structural racism and promote diversity in clinical research teams.
  
7/30/2021Grand RoundsMarie A. Bernard; George A. Mensah; Natalia Morone; Lesley CurtisNIH; National Heart, Lung, and Blood Institute (NHLBI); National Institute on Aging (NIA); Duke University School of Medicine; Boston University School of MedicineInclusion of Diverse Participants in Pragmatic Clinical Trials: Diversity in the PCT Ecosystem – How Do We Develop a Pipeline of Diverse Investigators and Leaders in PCTs?Dr. Curtis moderates a discussion with Drs. Bernard, Mensah, and Morone about initiatives and best practices to address structural racism and promote diversity in clinical research teams.
  
7/23/2021Grand RoundsDiana Berrent; Nick Guthe; Natalie LambertSurvivor Corps; Indiana University School of MedicineLong Term COVID Patient Engagement: Best Practices Informed By Patients’ Experiences Seeking Medical CareDiana Berrent and Nick Guthe, members of Survivor Corps, share their first-hand experiences with long-term COVID-19, while Dr. Lambert presents best practices for medical professionals treating patients experiencing debilitating effects of COVID-19.
  
7/23/2021Grand RoundsDiana Berrent; Natalie Lambert; Nick GutheIndiana University School of Medicine; Survivor CorpsLong Term COVID Patient Engagement: Best Practices Informed By Patients’ Experiences Seeking Medical Care Diana Berrent and Nick Guthe, members of Survivor Corps, share their first-hand experiences with long-term COVID-19, while Dr. Lambert presents best practices for medical professionals treating patients experiencing debilitating effects of COVID-19.
  
7/16/2021Grand RoundsAnne Trontell; David Chambers; Amanda MidboeNational Institutes of Health (NIH); National Cancer Institute (NCI); Department of Veterans Affairs; Patient-Centered Outcomes Research Institute (PCORI)Inclusion of Diverse Participants in Pragmatic Clinical Trials: Maximizing Diversity in Pragmatic Clinical Trials – What Can We Learn From Implementation Trials? Drs. Midboe and Trontell discuss methods to increase diverse patient engagement in implementation trials as part of the Inclusion of Diverse Participants in Pragmatic Clinical Trials Grand Rounds Series.
  
7/16/2021Grand RoundsAmanda Midboe; Anne Trontell; David ChambersNational Institutes of Health (NIH); National Cancer Institute (NCI); Department of Veterans Affairs; Patient-Centered Outcomes Research Institute (PCORI)Inclusion of Diverse Participants in Pragmatic Clinical Trials: Maximizing Diversity in Pragmatic ClinicalTrials – What Can We Learn From Implementation Trials? Drs. Midboe and Trontell discuss methods to increase diverse patient engagement in implementation trials as part of the Inclusion of Diverse Participants in Pragmatic Clinical Trials Grand Rounds Series.
  
7/9/2021Grand RoundsHana El SahyBaylor College of MedicineCOVID-19 Vaccine Efficacy Studies: Challenges and SuccessesDr. El Sahly discusses lessons learned from the COVID-19 vaccine efficacy studies.
  
7/9/2021Grand RoundsHana El SahyBaylor College of MedicineCOVID-19 Vaccine Efficacy Studies: Challenges and SuccessesDr. El Sahly discusses lessons learned from the COVID-19 vaccine efficacy studies.
  
6/25/2021Grand RoundsJudith Schlaeger; Stacy Sterling; Jonathan Jackson; Emily O'BrienDuke University School of Medicine; University of Illinois at Chicago; Kaiser Permanente Northern California Division of Research; Massachusetts General Hospital; Harvard Medical SchoolInclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize DiversityA moderated discussion about how to plan for and implement diversity in PCTs, focusing on strategies for outreach, trust, and consent.
  
6/25/2021Grand RoundsJudith Schlaeger; Stacy Sterling; Jonathan Jackson; Emily O'BrienDuke University School of Medicine; Massachusetts General Hospital; Kaiser Permanente Northern California Division of Research; Harvard Medical School; University of Illinois at ChicagoInclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize Diversity A moderated discussion about how to plan for and implement diversity in PCTs, focusing on strategies for outreach, trust, and consent.
  
6/18/2021Grand RoundsAndrew Ambrosy; Alan GoKaiser Permanente Northern California Division of ResearchThe MITIGATE Study: Insights from a Decentralized, Virtual, Electronic Health Record-Based Pragmatic Clinical Trial Drs. Ambrosy and Go present early insights from the MITIGATE trial that is evaluating an FDA-approved medication to prevent or reduce viral upper respiratory illness–related morbidity and mortality in patients with cardiovascular disease.
  
6/18/2021Grand RoundsAndrew Ambrosy; Alan GoKaiser Permanente Northern California Division of ResearchThe MITIGATE Study: Insights from a Decentralized, Virtual, Electronic Health Record-Based Pragmatic Clinical Trial Drs. Ambrosy and Go present early insights from the MITIGATE trial that is evaluating an FDA-approved medication to prevent or reduce viral upper respiratory illness–related morbidity and mortality in patients with cardiovascular disease.
  
6/11/2021Grand RoundsDouglas ZatzickUniversity of WashingtonThe TSOS Effectiveness-Implementation Hybrid Study: Health Care System Level Theoretical Considerations & Pragmatic Trial ResultsDr. Zatzick, PI of the TSOS effectiveness-implementation pragmatic clinical trial, presents the results and additional theoretical considerations.
  
6/11/2021Grand RoundsDouglas ZatzickUniversity of WashingtonThe TSOS Effectiveness-Implementation Hybrid Study: Health Care System Level Theoretical Considerations & Pragmatic Trial ResultsDr. Zatzick, PI of the TSOS effectiveness-implementation pragmatic clinical trial, presents the results and additional theoretical considerations.
  
6/4/2021Grand RoundsJulie Fritz; Amanda Petrik; Wendy Weber; Gloria Coronado; David WetterNIH; National Institutes of Health (NIH) the National Center for Complementary and Integrative Health (NCCIH); University of Utah; Kaiser Permanente Center for Health Research; Kaiser PermanenteInclusion of Diverse Participants in Pragmatic Clinical Trials: Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize DiversityPrincipal investigators of 2 Demonstration Projects discuss how to plan for and maximize clinical trial diversity through stakeholder engagement and site selection.
  
6/4/2021Grand RoundsJulie Fritz; Wendy Weber; David Wetter; Amanda Petrik; Gloria CoronadoKaiser Permanente Center for Health Research; Kaiser Permanente; NIH; National Institutes of Health (NIH) the National Center for Complementary and Integrative Health (NCCIH); University of UtahInclusion of Diverse Participants in Pragmatic Clinical Trials: Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize Diversity Principal investigators of 2 Demonstration Projects discuss how to plan for and maximize clinical trial diversity through stakeholder engagement and site selection.
  
5/21/2021Grand RoundsChris Butler; Ben SavilleUniversity of Oxford; Berry ConsultantsThe PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and DeliveryDrs. Saville and Butler describe how the PRINCIPLE clinical trial employs an innovative adaptive platform to study COVID-19 treatments and outcomes.
  
5/21/2021Grand RoundsChris Butler; Ben SavilleUniversity of Oxford; Berry ConsultantsThe PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and DeliveryDrs. Saville and Butler describe how the PRINCIPLE clinical trial employs an innovative adaptive platform to study COVID-19 treatments and outcomes.
  
5/14/2021Grand RoundsClyde YancyNorthwestern UniversityKeynote-Diverse Representation Among Clinical Trial Participants: Why It Is Important and How Can We ImproveDr. Yancy shares insights on the importance of diversity, not only among study participants but also in clinical trial leadership, and suggests concrete steps to advance diversity and change the way we evolve evidence in clinical trials.
  
5/14/2021Grand RoundsClyde YancyNorthwestern UniversityKeynote-Diverse Representation Among Clinical Trial Participants: Why It Is Important and How Can We ImproveDr. Yancy shares insights on the importance of diversity, not only among study participants but also in clinical trial leadership, and suggests concrete steps to advance diversity and change the way we evolve evidence in clinical trials.
  
5/7/2021Grand RoundsMegan RanneyBrown University School of Public Health; Brown University School of MedicineOnline Recruitment in the Era of COVID-19: Pitfalls and Progress Dr. Ranney discusses aspects of participant recruitment in clinical trials using social media and digital technologies during the COVID-19 pandemic.
  
5/7/2021Grand RoundsMegan RanneyBrown University School of Public Health; Brown University School of MedicineOnline Recruitment in the Era of COVID-19: Pitfalls and Progress Dr. Ranney discusses aspects of participant recruitment in clinical trials using social media and digital technologies during the COVID-19 pandemic.
  
4/30/2021Grand RoundsSusanna Naggie; Elizabeth ShenkmanDuke Clinical Research Institute; University of FloridaACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications Drs. Naggie and Shenkman discuss the ACTIV-6 direct-to-participants trial of COVID-19 treatments evaluating repurposed drugs.
  
4/30/2021Grand RoundsSusanna Naggie; Elizabeth ShenkmanDuke Clinical Research Institute; University of FloridaACTIV-6: COVID-19 Outpatient Randomized Trial to Evaluate Efficacy of Repurposed Medications Drs. Naggie and Shenkman discuss the ACTIV-6 direct-to-participants trial of COVID-19 treatments evaluating repurposed drugs.
  
4/23/2021Grand RoundsSamuel BrownUniversity of UtahCOVID Clinical Trials: The Intermountain Healthcare ExperienceDr. Brown presents the challenges and successes of integrating COVID-19 clinical research in the Intermountain Healthcare system during the pandemic.
  
4/23/2021Grand RoundsSamuel BrownUniversity of UtahCOVID Clinical Trials: The Intermountain Healthcare ExperienceDr. Brown presents the challenges and successes of integrating COVID-19 clinical research in the Intermountain Healthcare system during the pandemic.
  
4/16/2021Grand RoundsTyler Winkelman; Paul DrawzUniversity of Minnesota; Hennepin Healthcare Research InstituteMinnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine Equity Drs. Winkelman and Drawz describe how the Minnesota Electronic Health Record Consortium is informing COVID-19 vaccine equity in Minnesota.
  
4/16/2021Grand RoundsTyler Winkelman; Paul DrawzUniversity of Minnesota; Hennepin Healthcare Research InstituteMinnesota EHR Consortium COVID-19 Project: A Statewide Collaboration to Inform Vaccine EquityDrs. Winkelman and Drawz describe how the Minnesota Electronic Health Record Consortium is informing COVID-19 vaccine equity in Minnesota.
  
4/9/2021Grand RoundsAdit GindeUniversity of Colorado School of MedicineTaking Research to the Participant: Experiences with TREAT NOW, a No-Touch COVID-19 Trial Dr. Ginde presents experiences with an ongoing “no-touch” clinical trial on COVID-19 treatments.
  
4/2/2021Grand RoundsDerek AngusUniversity of PittsburghLessons from COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform Trial Dr. Angus describes the adaptive platform trial REMAP-CAP and how it was expanded to evaluate treatment interventions for patients hospitalized with COVID-19.
  
4/2/2021Grand RoundsDerek AngusUniversity of PittsburghLessons from COVID-19: The First Year of the REMAP-CAP Global Adaptive Platform TrialDr. Angus describes the adaptive platform trial REMAP-CAP and how it was expanded to evaluate treatment interventions for patients hospitalized with COVID-19.
  
3/26/2021Grand RoundsRobert GreenHarvard Medical School; Massachusetts General HospitalThe Path to Preventive Genomics Dr. Green discusses the role of genomics in predicting, and potentially preventing, the onset of disease in healthy people.
  
3/26/2021Grand RoundsRobert GreenHarvard Medical School; Massachusetts General HospitalThe Path to Preventive Genomics Dr. Green discusses the role of genomics in predicting, and potentially preventing, the onset of disease in healthy people.
  
3/19/2021Grand RoundsEmily O'Brien; Robert CaliffDuke Clinical Research Institute; Verily Life SciencesHERO–Learning Together about Vaccines for SARS-CoV-2 Drs. O’Brien and Califf discuss the HERO Program supporting research around COVID-19 vaccines in the community of healthcare workers.
  
3/19/2021Grand RoundsEmily O'Brien; Robert CaliffDuke Clinical Research Institute; Verily Life SciencesHERO–Learning Together about Vaccines for SARS-CoV-2 Drs. O’Brien and Califf discuss the HERO Program supporting research around COVID-19 vaccines in the community of healthcare workers.
  
3/12/2021Grand RoundsJintanat Ananworanich; Mohamed BassyouniBill and Melinda Gates Medical Research InstituteLessons Learned from the Gates MRI Virtual COVID-19 TrialDrs. Bassyouni and Ananworanich discuss the innovative COVID-19 therapeutics accelerator program established by the Gates Medical Research Institute.
  
3/12/2021Grand RoundsJintanat Ananworanich; Mohamed BassyouniBill and Melinda Gates Medical Research InstituteLessons Learned from the Gates MRI Virtual COVID-19 TrialDrs. Bassyouni and Ananworanich discuss the innovative COVID-19 therapeutics accelerator program established by the Gates Medical Research Institute.
  
3/5/2021Grand RoundsSusan EllenbergUniversity of PennsylvaniaData and Safety Monitoring Boards for Trials of COVID-19 Vaccines: The Challenges Dr. Ellenberg describes challenges encountered by the DSMB that is monitoring a group of COVID-19 vaccine trials under the National Institutes of Health.
  
3/5/2021Grand RoundsSusan EllenbergUniversity of PennsylvaniaData and Safety Monitoring Boards for Trials of COVID-19 Vaccines: The ChallengesDr. Ellenberg describes challenges encountered by the DSMB that is monitoring a group of COVID-19 vaccine trials under the National Institutes of Health.
  
2/26/2021Grand RoundsSebastian SchneeweissHarvard Medical SchoolCalibrating Real-World Evidence Against RCT Evidence: Early Learnings from RCT-DUPLICATEDr. Schneeweiss discusses how real-world evidence (RWE) studies can emulate randomized clinical trials.
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