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1/8/2021Grand RoundsEmily O'BrienDuke Clinical Research Institute; Duke University School of MedicineHERO-TOGETHER: Building Vaccine Confidence With Long-Term Outcomes DataDr. O’Brien discusses the HERO-TOGETHER initiative that aims to understand how healthcare workers do after receiving a COVID-19 vaccination.
  
1/8/2021Grand RoundsEmily O'BrienDuke Clinical Research Institute; Duke University School of MedicineHERO-TOGETHER: Building Vaccine Confidence With Long-Term Outcomes DataDr. O’Brien discusses the HERO-TOGETHER initiative that aims to understand how healthcare workers do after receiving a COVID-19 vaccination.
  
12/18/2020Grand RoundsMatthew Shun-ShinImperial College LondonThe SAMSON Trial: An N-of-1 Trial of Statin, Placebo, and No Treatment to Assess Patient Symptoms Dr. Shun-Shin describes the design and results of the SAMSON trial that evaluated perceived side effects of statin medications.
  
12/18/2020Grand RoundsMatthew Shun-ShinImperial College LondonThe SAMSON Trial: An N-of-1 Trial of Statin, Placebo, and No Treatment to Assess Patient Symptoms Dr. Shun-Shin describes the design and results of the SAMSON trial that evaluated perceived side effects of statin medications.
  
12/11/2020Grand RoundsSchuyler Jones ; Karen AlexanderDuke University; Duke Clinical Research InstitutePREVENTABLE: Starting a Pragmatic Trial in a PandemicDrs. Alexander and Jones describe the challenges of starting a trial during the COVID-19 pandemic.
  
12/11/2020Grand RoundsKaren Alexander; Schuyler Jones Duke Clinical Research Institute; Duke UniversityPREVENTABLE: Starting a Pragmatic Trial in a Pandemic Drs. Alexander and Jones describe the challenges of starting a trial during the COVID-19 pandemic.
  
12/4/2020Grand RoundsTariq AhmadYale University School of MedicineThe Yale New Haven Health System as an Evidence Generation Ecosystem for Heart FailureDr. Ahmad discusses studies evaluating data-driven methodologies for predicting clinical outcomes in patients with heart failure.
  
12/4/2020Grand RoundsTariq AhmadYale University School of MedicineThe Yale New Haven Health System as an Evidence Generation Ecosystem for Heart FailureDr. Ahmad discusses studies evaluating data-driven methodologies for predicting clinical outcomes in patients with heart failure.
  
11/20/2020Grand RoundsDaniel EdmonstonDuke University School of MedicineDrug Development in Kidney Disease: Proceedings from a Multi-Stakeholder Panel Dr. Edmonston describes the landscape of drug development and clinical trials evaluating treatments for chronic kidney disease.
  
11/20/2020Grand RoundsDaniel EdmonstonDuke University School of MedicineDrug Development in Kidney Disease: Proceedings from a Multi-Stakeholder PanelDr. Edmonston describes the landscape of drug development and clinical trials evaluating treatments for chronic kidney disease.
  
11/13/2020Grand RoundsMerrick Zwarenstein; Amit Garg; Ahmed Al-JaishiMcMaster University; Western UniversityPragmatic and Explanatory Attitudes to RCTs: Using the PRECIS-2 Tool to Describe the Design of the MyTEMP Trial Drs. Zwarenstein, Al-Jaishi, and Garg discuss the differences between explanatory and pragmatic approaches to randomized controlled trials as illustrated by two contrasting trials.
  
11/13/2020Grand RoundsMerrick Zwarenstein; Amit Garg; Ahmed Al-JaishiMcMaster University; Western UniversityPragmatic and Explanatory Attitudes to RCTs: Using the PRECIS-2 Tool to Describe the Design of the MyTEMP Trial Drs. Zwarenstein, Al-Jaishi, and Garg discuss the differences between explanatory and pragmatic approaches to randomized controlled trials as illustrated by two contrasting trials.
  
11/6/2020Grand RoundsDavid FlumUniversity of WashingtonAppendectomy Versus Antibiotics for Appendicitis–Early Results from the CODA Trial Dr. Flum discusses the CODA comparative effectiveness trial that compared two treatments for appendicitis.
  
11/6/2020Grand RoundsDavid FlumUniversity of WashingtonAppendectomy Versus Antibiotics for Appendicitis–Early Results from the CODA Trial Dr. Flum discusses the CODA comparative effectiveness trial that compared two treatments for appendicitis.
  
10/30/2020Grand RoundsDavid BoulwareUniversity of MinnesotaLessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience Dr. Boulware describes how his study team was able to rapidly set up virtual clinical trials during the early days of the COVID-19 pandemic.
  
10/30/2020Grand RoundsDavid BoulwareUniversity of MinnesotaLessons from Virtual Trials in Time of a Pandemic: Minnesota Hydroxychloroquine Experience Dr. Boulware describes how his study team was able to rapidly set up virtual clinical trials during the early days of the COVID-19 pandemic.
  
10/23/2020Grand RoundsJoAnn Sperl-Hillen; Patrick O'ConnorHealthPartners InstituteOutpatient Clinical Decision Support – An Evidence-Based Implementation Framework Drs. Sperl-Hillen and O’Connor share lessons learned in the development of a clinical decision support system used in primary care visits.
  
10/23/2020Grand RoundsJoAnn Sperl-Hillen; Patrick O'ConnorHealthPartners InstituteOutpatient Clinical Decision Support – An Evidence-Based Implementation Framework Drs. Sperl-Hillen and O’Connor share lessons learned in the development of a clinical decision support system used in primary care visits.
  
10/16/2020Grand RoundsDanny Benjamin; Kanecia ZimmermanDuke Clinical Research Institute; Duke University School of MedicineBack to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative Drs. Zimmerman and Benjamin discuss the ABC Science Collaborative, which aims to unite science and schools for a data-driven solution to decision-making and implementation around mitigating COVID-19.
  
10/16/2020Grand RoundsKanecia Zimmerman; Danny BenjaminDuke University School of Medicine; Duke Clinical Research InstituteBack to School, It’s More Than Just a Trip to Target This Year: The ABC Science Collaborative Drs. Zimmerman and Benjamin discuss the ABC Science Collaborative, which aims to unite science and schools for a data-driven solution to decision-making and implementation around mitigating COVID-19.
  
10/9/2020Grand RoundsMyles WolfDuke University; Duke Clinical Research InstitutePragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo) (GR Slides 2020)Dr. Wolf presents an update on HiLo, an NIDDK-funded pragmatic trial testing which phosphate treatment target provides the best clinical outcomes for patients.
  
10/9/2020Grand RoundsMyles WolfDuke University; Duke Clinical Research InstitutePragmatic Trial of Higher vs. Lower Serum Phosphate Targets in Patients Undergoing Hemodialysis (HiLo) (GR Video 2020)Dr. Wolf presents an update on HiLo, an NIDDK-funded pragmatic trial testing which phosphate treatment target provides the best clinical outcomes for patients.
  
10/2/2020Grand RoundsNakela CookPatient-Centered Outcomes Research Institute (PCORI)Driving Toward Health Impact: Our Journey and Path ForwardDr. Cook presents highlights of PCORI’s 2.0 strategic plan to accelerate the impact on health care and patient outcomes.
  
10/2/2020Grand RoundsNakela CookPatient-Centered Outcomes Research Institute (PCORI)Driving Toward Health Impact: Our Journey and Path Forward Dr. Cook presents highlights of PCORI’s 2.0 strategic plan to accelerate the impact on health care and patient outcomes.
  
9/25/2020Grand RoundsRachael Fleurence; Rick BrightNIHAccelerating the Nation’s COVID-19 Testing Capacity: An Update from the NIH’s RADx ProgramDrs. Fleurence and Bright describe a collaborative and innovative national effort to accelerate COVID-19 testing.
  
9/25/2020Grand RoundsRick Bright; Rachael FleurenceNIHAccelerating the Nation’s COVID-19 Testing Capacity: An Update from the NIH’s RADx ProgramDrs. Fleurence and Bright describe a collaborative and innovative national effort to accelerate COVID-19 testing.
  
9/11/2020Grand RoundsGordon Bernard; Sonia ThomasVanderbilt University Medical Center; Research Triangle InstituteLaunching CONNECTS: Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies Drs. Thomas and Bernard discuss the launch of a new network for collaborative COVID-19 research.
  
9/11/2020Grand RoundsSonia Thomas; Gordon BernardResearch Triangle Institute; Vanderbilt University Medical CenterLaunching CONNECTS: Collaborating Network of Networks for Evaluating COVID-19 and Therapeutic Strategies Drs. Thomas and Bernard discuss the launch of a new network for collaborative COVID-19 research.
  
8/28/2020Grand RoundsLesley Curtis; Frank Rockhold; Trevor LentzDuke Clinical Research Institute; Duke University School of MedicineDesigning, Conducting, Monitoring, and Analyzing Data from Pragmatic Clinical Trials: Proceedings from a Multi-Stakeholder Think Tank MeetingDrs. Lentz, Curtis, and Rockhold present discussions and findings from a think tank meeting about challenges and best practices for PCTs.
  
8/28/2020Grand RoundsLesley Curtis; Frank Rockhold; Trevor LentzDuke Clinical Research Institute; Duke University School of MedicineDesigning, Conducting, Monitoring, and Analyzing Data from Pragmatic Clinical Trials: Proceedings from a Multi-Stakeholder Think Tank MeetingDrs. Lentz, Curtis, and Rockhold present discussions and findings from a think tank meeting about challenges and best practices for PCTs.
  
8/21/2020Grand RoundsLaura EssermanUniversity of California, San FranciscoAdaptive Platform Trials: Scalable from Breast Cancer to COVIDDr. Esserman discusses how the innovative adaptive platform trial, I-SPY COVID, will be used to evaluate and prioritize high-impact treatments for COVID-19.
  
8/21/2020Grand RoundsLaura EssermanUniversity of California, San FranciscoAdaptive Platform Trials: Scalable from Breast Cancer to COVID Dr. Esserman discusses how the innovative adaptive platform trial, I-SPY COVID, will be used to evaluate and prioritize high-impact treatments for COVID-19.
  
8/14/2020Grand RoundsAndrea Cheville; Jon TilburtMayo ClinicLearning While Sprinting: A One-Year Retrospective from the NOHARM Pragmatic Trial (GR Slides 2020)Drs. Cheville and Tilburt describe the pilot year of NOHARM, an NIH Collaboratory Demonstration Project in the NIH HEAL Initiative’s PRISM portfolio.
  
8/14/2020Grand RoundsAndrea Cheville; Jon TilburtMayo ClinicLearning While Sprinting: A One-Year Retrospective from the NOHARM Pragmatic Trial (GR Video 2020)Drs. Cheville and Tilburt describe the pilot year of NOHARM, an NIH Collaboratory Demonstration Project in the NIH HEAL Initiative’s PRISM portfolio.
  
8/7/2020Grand RoundsMichael GibsonHarvard Medical SchoolThe Democratization of Medicine: Open Access, Social Media, AI, Apps, and Empowering the Patient as the Future of Clinical Research Dr. Gibson discusses how open access, patient empowerment, social media, and digital health are transforming clinical trials.
  
8/7/2020Grand RoundsMichael GibsonHarvard Medical SchoolThe Democratization of Medicine: Open Access, Social Media, AI, Apps, and Empowering the Patient as the Future of Clinical Research Dr. Gibson discusses how open access, patient empowerment, social media, and digital health are transforming clinical trials.
  
7/31/2020Grand RoundsSudha Raman; John SheehanDuke University; Clinical Trials Transformation Initiative (CTTI); Janssen Scientific AffairsUsing Real-World Data to Plan Eligibility Criteria and Enhance Recruitment: Actionable Recommendations and Resources from the Clinical Trials Transformation InitiativeDrs. Raman and Sheehan present recommendations and resources from CTTI for using real-world data for planning clinical trial recruitment.
  
7/31/2020Grand RoundsSudha Raman; John SheehanDuke University; Clinical Trials Transformation Initiative (CTTI); Janssen Scientific AffairsUsing Real-World Data to Plan Eligibility Criteria and Enhance Recruitment: Actionable Recommendations and Resources from the Clinical Trials Transformation InitiativeDrs. Raman and Sheehan present recommendations and resources from CTTI for using real-world data for planning clinical trial recruitment.
  
7/24/2020Grand RoundsKathleen Sluka; Leslie CroffordUniversity of Iowa; Vanderbilt UniversityTENS in Fibromyalgia: From Fundamental Neurobiology to Pragmatic Trial (GR Slides 2020)Drs. Crofford and Sluka describe the neurobiology behind fibromyalgia and the aims of their embedded pragmatic trial, Fibromyalgia TENS in Physical Therapy Study (FM TIPS), an NIH Collaboratory Demonstration Project.
  
7/24/2020Grand RoundsKathleen Sluka; Leslie CroffordUniversity of Iowa; Vanderbilt UniversityTENS in Fibromyalgia: From Fundamental Neurobiology to Pragmatic Trial (GR Video 2020)Drs. Crofford and Sluka describe the neurobiology behind fibromyalgia and the aims of their embedded pragmatic trial, Fibromyalgia TENS in Physical Therapy Study (FM TIPS), an NIH Collaboratory Demonstration Project.
  
7/17/2020Grand RoundsDevon Check; Rachel RichessonDuke University School of Nursing; Duke Clinical Research InstituteLiving Textbook Grand Rounds Series: Part 5-Choosing What to Measure and Making it Happen: Your Keys to Pragmatic Trial Success (GR Slides 2020) Drs. Check and Richesson discuss methods for measuring outcomes in embedded pragmatic clinical trials (ePCTs).
  
7/17/2020Grand RoundsDevon Check; Rachel RichessonDuke University School of Nursing; Duke Clinical Research InstituteLiving Textbook Grand Rounds Series: Part 5-Choosing What to Measure and Making it Happen: Your Keys to Pragmatic Trial Success (GR Video 2020) Drs. Check and Richesson discuss methods for measuring outcomes in embedded pragmatic clinical trials (ePCTs).
  
7/10/2020Grand RoundsKen Gersing; Robert StarNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National Center for Advancing Translational Sciences (NCATS); National Institutes of Health (NIH)COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C)Drs. Gersing and Star present an emerging national platform for COVID-19 clinical research.
  
7/10/2020Grand RoundsKen Gersing; Robert StarNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK); National Center for Advancing Translational Sciences (NCATS); National Institutes of Health (NIH)COVID Open Science Collaborative Analytics Platform: National COVID Cohort Collaborative (N3C) Drs. Gersing and Star present an emerging national platform for COVID-19 clinical research.
  
6/26/2020Grand RoundsKeith Marsolo; George Oliver; Rachel Richesson; Teresa Zayas-Cabán; Christopher LonghurstDuke University; The Office of the National Coordinator for Health Information Technology (ONC); Duke University School of Nursing; Parkland Center for Clinical Innovations; UC San Diego HealthEHR Core Workshop: Keys to Success in the Evolving EHR Environment (GR Slides 2020)A panel of experts discusses experiences and challenges in advancing the use of electronic data in embedded pragmatic clinical trials.
  
6/26/2020Grand RoundsKeith Marsolo; Rachel Richesson; Teresa Zayas-Cabán; Christopher Longhurst; George OliverDuke University; Duke University School of Nursing; The Office of the National Coordinator for Health Information Technology (ONC); Parkland Center for Clinical Innovations; UC San Diego HealthEHR Core Workshop: Keys to Success in the Evolving EHR Environment (GR Video 2020)A panel of experts discusses experiences and challenges in advancing the use of electronic data in embedded pragmatic clinical trials.
  
6/19/2020Grand RoundsLiz Turner; Patrick Heagerty; David MurrayDuke University; NIH; University of WashingtonLiving Textbook Grand Rounds Series: Part 4-Demystifying Biostatistical Concepts for Embedded Pragmatic Clinical Trials (GR Slides 2020)Drs. Turner, Murray, and Heagerty describe statistical issues in study designs for embedded pragmatic clinical trials.
  
6/19/2020Grand RoundsLiz Turner; Patrick Heagerty; David MurrayDuke University; University of Washington; NIHLiving Textbook Grand Rounds Series: Part 4-Demystifying Biostatistical Concepts for Embedded Pragmatic Clinical Trials (GR Video 2020)Drs. Turner, Murray, and Heagerty describe statistical issues in study designs for embedded pragmatic clinical trials.
  
6/12/2020Grand RoundsSusan MitchellHarvard Medical SchoolA Cluster Randomized Pragmatic Trial of an Advance Care Planning Video Intervention in Long-Stay Nursing Home Residents: Main Findings from the PROVEN Trial (GR Slides 2020)Dr. Mitchell presents findings from the PROVEN Trial, an NIH Collaboratory Demonstration Project that studied the effect of showing advance care planning videos to long-stay nursing home residents.
  
6/12/2020Grand RoundsSusan MitchellHarvard Medical SchoolA Cluster Randomized Pragmatic Trial of an Advance Care Planning Video Intervention in Long-Stay Nursing Home Residents: Main Findings from the PROVEN Trial (GR Video 2020)Dr. Mitchell presents findings from the PROVEN Trial, an NIH Collaboratory Demonstration Project that studied the effect of showing advance care planning videos to long-stay nursing home residents.
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