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11/19/2021Grand RoundsAnish AgarwalUniversity of PennsylvaniaExploring Approaches in Using Digital and Mobile Health in Patient-oriented Research: Pearls and PitfallsDr. Anish Agarwal discusses the rapidly changing landscape of digital and mobile devices in patient-oriented research.
  
11/19/2021Grand RoundsAnish AgarwalUniversity of PennsylvaniaExploring Approaches in Using Digital and Mobile Health in Patient-oriented Research: Pearls and PitfallsDr. Anish Agarwal discusses the rapidly changing landscape of digital and mobile devices in patient-oriented research.
  
11/12/2021Grand RoundsCharlene Wong; Noel BrewerDepartment of Health and Human Services (HHS); Duke University School of Medicine; University of North CarolinaUsing Financial Incentives to Increase COVID-19 Vaccine UptakeDr. Wong and Dr. Brewer discuss the results of a financial incentive program to encourage COVID-19 vaccination in North Carolina.
  
11/12/2021Grand RoundsCharlene Wong; Noel BrewerDepartment of Health and Human Services (HHS); Duke University School of Medicine; University of North CarolinaUsing Financial Incentives to Increase COVID-19 Vaccine UptakeDr. Wong and Dr. Brewer discuss the results of a financial incentive program to encourage COVID-19 vaccination in North Carolina.
  
11/5/2021Grand RoundsJames GrottaMemorial Hermann Hospital-Texas Medical CenterBenefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU StudyDr. James Grotta discusses the BEST-MSU Study and the benefits of stroke treatment delivered using a mobile stroke unit compared to standard management by emergency medical services.
  
11/5/2021Grand RoundsJames GrottaMemorial Hermann Hospital-Texas Medical CenterBenefits of Stroke Treatment Delivered Using a Mobile Stroke Unit Compared to Standard Management by Emergency Medical Services: The BEST-MSU StudyDr. James Grotta discusses the BEST-MSU Study and the benefits of stroke treatment delivered using a mobile stroke unit compared to standard management by emergency medical services.
  
10/29/2021Grand RoundsJonathan Casey; Matthew SemlerVanderbilt University Medical CenterEmbedding Pragmatic Trials into Emergency and Critical CareDr. Semler and Dr. Casey discuss the challenges of embedding pragmatic trials into emergency and critical care.
  
10/29/2021Grand RoundsJonathan Casey; Matthew SemlerVanderbilt University Medical CenterEmbedding Pragmatic Trials into Emergency and Critical CareDr. Semler and Dr. Casey discuss the challenges of embedding pragmatic trials into emergency and critical care.
  
10/22/2021Grand RoundsTerri FriedYale University School of MedicineIncreasing Engagement in Advance Care Planning and Lessons Learned from Partnering with Community Ambulatory PracticesDr. Fried shares the results of the STAMP Trial, a cluster-randomized trial to increase patient engagement in Advance Care Planning.
  
10/22/2021Grand RoundsTerri FriedYale University School of MedicineThe STAMP Trial: Increasing Engagement in Advance Care Planning and Lessons Learned from Partnering with Community Ambulatory PracticesDr. Fried shares the results of the STAMP Trial, a cluster-randomized trial to increase patient engagement in Advance Care Planning.
  
10/15/2021Grand RoundsJason AbaluckYale School of ManagementThe Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in BangladeshDr. Abaluck shares the results of a cluster-randomized trial examining the impact of community masking on COVID-19 in Bangladesh.
  
10/15/2021Grand RoundsJason AbaluckYale School of ManagementThe Impact of Community Masking on COVID-19: A Cluster-Randomized Trial in BangladeshDr. Abaluck shares the results of a cluster-randomized trial examining the impact of community masking on COVID-19 in Bangladesh.
  
10/8/2021Grand RoundsSchuyler Jones ; Madelaine FaulknerDuke University School of Medicine; University of California, San FranciscoLessons Learned and Patient Partnership in ADAPTABLEDr. Schuyler Jones and Madelaine Faulkner discuss patient engagement and study design in the ADAPTABLE aspirin trial.
  
10/8/2021Grand RoundsSchuyler Jones ; Madelaine FaulknerDuke University School of Medicine; University of California, San FranciscoLessons Learned and Patient Partnership in ADAPTABLEDr. Schuyler Jones and Madelaine Faulkner discuss patient engagement and study design in the ADAPTABLE aspirin trial.
  
10/1/2021Grand RoundsCarolyn Bramante; Thomas Murray; Jared HulingUniversity of MinnesotaCOVID-OUT: From Computer Modeling to a Phase III Trial of Early Outpatient Treatment for SARS-CoV-2 InfectionDr. Bramante, Dr. Murray, and Dr. Huling discuss the design and progress of the COVID-OUT Trial for early outpatient treatment of SARS-CoV-2 infection.
  
10/1/2021Grand RoundsCarolyn Bramante; Jared Huling; Thomas MurrayUniversity of MinnesotaCOVID-OUT: From Computer Modeling to a Phase III Trial of Early Outpatient Treatment for SARS-CoV-2 InfectionDr. Bramante, Dr. Murray, and Dr. Huling discuss the design and progress of the COVID-OUT Trial for early outpatient treatment of SARS-CoV-2 infection.
  
9/24/2021Grand RoundsKevin Weinfurt; Theresa ColesDuke University School of MedicineEnabling Patient-Reported Outcome Measures (PROMs) in Clinical Trials, Exemplified by Cardiovascular Trials Dr. Coles and Dr. Weinfurt discuss Patient-Reported Outcome Measures (PROMs) and the importance of Modern Validity Theory in developing PROMs.
  
9/24/2021Grand RoundsKevin Weinfurt; Theresa ColesDuke University School of MedicineEnabling Patient-Reported Outcome Measures (PROMs) in Clinical Trials, Exemplified by Cardiovascular Trials Dr. Coles and Dr. Weinfurt discuss Patient-Reported Outcome Measures (PROMs) and the importance of Modern Validity Theory in developing PROMs.
  
9/10/2021Grand RoundsBruce NealImperial College London; George Institute Australia; University of SydneyEffect of Salt Substitution on Cardiovascular Events and DeathDr. Neal shares the results from the SSaSS study on the effects of reduced-sodium, added-potassium salt substitute on stroke, cardiovascular events, and death.
  
9/10/2021Grand RoundsBruce NealGeorge Institute Australia; Imperial College London; University of SydneyEffect of Salt Substitution on Cardiovascular Events and DeathDr. Neal shares the results from the SSaSS study on the effects of reduced-sodium, added-potassium salt substitute on stroke, cardiovascular events, and death.
  
8/27/2021Grand RoundsBenjamin HibbertUniversity of OttawaMilrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trialDr. Hibbert shares the results from the CAPITAL DOREMI study and discusses the importance of randomized pragmatic clinical trials to generate quality data on therapeutics.
  
8/27/2021Grand RoundsBenjamin HibbertUniversity of OttawaMilrinone as Compared with Dobutamine in the Treatment of Cardiogenic Shock: the DOREMI trial Dr. Hibbert shares the results from the CAPITAL DOREMI study and discusses the importance of randomized pragmatic clinical trials to generate quality data on therapeutics.
  
8/20/2021Grand RoundsEric LenzeWashington University in St. LouisFluvoxamine for early treatment of COVID-19: the STOP COVID clinical trialsDr. Eric Lenze discusses the STOP COVID trials, the latest research on Fluvoxamine for the early treatment of COVID-19.
  
8/20/2021Grand RoundsEric LenzeWashington University in St. LouisFluvoxamine for early treatment of COVID-19: the STOP COVID clinical trialsDr. Eric Lenze discusses the STOP COVID trials, the latest research on Fluvoxamine for the early treatment of COVID-19.
  
8/13/2021Grand RoundsDavey SmithUniversity of California, San DiegoGot anything for this cough? Outpatient Treatment Trials in the Time of COVIDDr. Smith discusses the history of proposed therapies for COVID-19 and how the Adaptive Platform Trial ACTIV -2 seeks to find a successful new therapy.
  
8/13/2021Grand RoundsDavey SmithUniversity of California, San DiegoGot anything for this cough? Outpatient Treatment Trials in the Time of COVIDDr. Smith discusses the history of proposed therapies for COVID-19 and how the Adaptive Platform Trial ACTIV -2 seeks to find a successful new therapy.
  
8/6/2021Grand RoundsEdward MillsMcMaster UniversityEarly Treatment of COVID-19 with Repurposed Therapies: The TOGETHER Adaptive Platform Trial Dr. Mills shares the latest data on Repurposed Therapies for COVID-19 and discusses the elements of successful Adaptive Platform Trials.
  
8/6/2021Grand RoundsEdward MillsMcMaster UniversityEarly Treatment of COVID-19 with Repurposed Therapies: The TOGETHER Adaptive Platform Trial Dr. Mills shares the latest data on Repurposed Therapies for COVID-19 and discusses the elements of successful Adaptive Platform Trials.
  
7/30/2021Grand RoundsNatalia Morone; George A. Mensah; Marie A. Bernard; Lesley CurtisNational Institute on Aging (NIA); NIH; National Heart, Lung, and Blood Institute (NHLBI); Duke University School of Medicine; Boston University School of MedicineInclusion of Diverse Participants in Pragmatic Clinical Trials: Diversity in the PCT Ecosystem – How Do We Develop a Pipeline of Diverse Investigators and Leaders in PCTs?Dr. Curtis moderates a discussion with Drs. Bernard, Mensah, and Morone about initiatives and best practices to address structural racism and promote diversity in clinical research teams.
  
7/30/2021Grand RoundsMarie A. Bernard; George A. Mensah; Natalia Morone; Lesley CurtisNIH; National Heart, Lung, and Blood Institute (NHLBI); National Institute on Aging (NIA); Duke University School of Medicine; Boston University School of MedicineInclusion of Diverse Participants in Pragmatic Clinical Trials: Diversity in the PCT Ecosystem – How Do We Develop a Pipeline of Diverse Investigators and Leaders in PCTs?Dr. Curtis moderates a discussion with Drs. Bernard, Mensah, and Morone about initiatives and best practices to address structural racism and promote diversity in clinical research teams.
  
7/23/2021Grand RoundsDiana Berrent; Nick Guthe; Natalie LambertSurvivor Corps; Indiana University School of MedicineLong Term COVID Patient Engagement: Best Practices Informed By Patients’ Experiences Seeking Medical CareDiana Berrent and Nick Guthe, members of Survivor Corps, share their first-hand experiences with long-term COVID-19, while Dr. Lambert presents best practices for medical professionals treating patients experiencing debilitating effects of COVID-19.
  
7/23/2021Grand RoundsDiana Berrent; Natalie Lambert; Nick GutheIndiana University School of Medicine; Survivor CorpsLong Term COVID Patient Engagement: Best Practices Informed By Patients’ Experiences Seeking Medical Care Diana Berrent and Nick Guthe, members of Survivor Corps, share their first-hand experiences with long-term COVID-19, while Dr. Lambert presents best practices for medical professionals treating patients experiencing debilitating effects of COVID-19.
  
7/16/2021Grand RoundsAnne Trontell; David Chambers; Amanda MidboeNational Institutes of Health (NIH); National Cancer Institute (NCI); Department of Veterans Affairs; Patient-Centered Outcomes Research Institute (PCORI)Inclusion of Diverse Participants in Pragmatic Clinical Trials: Maximizing Diversity in Pragmatic Clinical Trials – What Can We Learn From Implementation Trials? Drs. Midboe and Trontell discuss methods to increase diverse patient engagement in implementation trials as part of the Inclusion of Diverse Participants in Pragmatic Clinical Trials Grand Rounds Series.
  
7/16/2021Grand RoundsAmanda Midboe; Anne Trontell; David ChambersNational Institutes of Health (NIH); National Cancer Institute (NCI); Department of Veterans Affairs; Patient-Centered Outcomes Research Institute (PCORI)Inclusion of Diverse Participants in Pragmatic Clinical Trials: Maximizing Diversity in Pragmatic ClinicalTrials – What Can We Learn From Implementation Trials? Drs. Midboe and Trontell discuss methods to increase diverse patient engagement in implementation trials as part of the Inclusion of Diverse Participants in Pragmatic Clinical Trials Grand Rounds Series.
  
7/9/2021Grand RoundsHana El SahyBaylor College of MedicineCOVID-19 Vaccine Efficacy Studies: Challenges and SuccessesDr. El Sahly discusses lessons learned from the COVID-19 vaccine efficacy studies.
  
7/9/2021Grand RoundsHana El SahyBaylor College of MedicineCOVID-19 Vaccine Efficacy Studies: Challenges and SuccessesDr. El Sahly discusses lessons learned from the COVID-19 vaccine efficacy studies.
  
6/25/2021Grand RoundsJudith Schlaeger; Stacy Sterling; Jonathan Jackson; Emily O'BrienDuke University School of Medicine; University of Illinois at Chicago; Kaiser Permanente Northern California Division of Research; Massachusetts General Hospital; Harvard Medical SchoolInclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize DiversityA moderated discussion about how to plan for and implement diversity in PCTs, focusing on strategies for outreach, trust, and consent.
  
6/25/2021Grand RoundsJudith Schlaeger; Stacy Sterling; Jonathan Jackson; Emily O'BrienDuke University School of Medicine; Massachusetts General Hospital; Kaiser Permanente Northern California Division of Research; Harvard Medical School; University of Illinois at ChicagoInclusion of Diverse Participants in Pragmatic Clinical Trials: Meeting Participants Where They Are – Outreach, Trust, and Consent to Maximize Diversity A moderated discussion about how to plan for and implement diversity in PCTs, focusing on strategies for outreach, trust, and consent.
  
6/18/2021Grand RoundsAndrew Ambrosy; Alan GoKaiser Permanente Northern California Division of ResearchThe MITIGATE Study: Insights from a Decentralized, Virtual, Electronic Health Record-Based Pragmatic Clinical Trial Drs. Ambrosy and Go present early insights from the MITIGATE trial that is evaluating an FDA-approved medication to prevent or reduce viral upper respiratory illness–related morbidity and mortality in patients with cardiovascular disease.
  
6/18/2021Grand RoundsAndrew Ambrosy; Alan GoKaiser Permanente Northern California Division of ResearchThe MITIGATE Study: Insights from a Decentralized, Virtual, Electronic Health Record-Based Pragmatic Clinical Trial Drs. Ambrosy and Go present early insights from the MITIGATE trial that is evaluating an FDA-approved medication to prevent or reduce viral upper respiratory illness–related morbidity and mortality in patients with cardiovascular disease.
  
6/11/2021Grand RoundsDouglas ZatzickUniversity of WashingtonThe TSOS Effectiveness-Implementation Hybrid Study: Health Care System Level Theoretical Considerations & Pragmatic Trial ResultsDr. Zatzick, PI of the TSOS effectiveness-implementation pragmatic clinical trial, presents the results and additional theoretical considerations.
  
6/11/2021Grand RoundsDouglas ZatzickUniversity of WashingtonThe TSOS Effectiveness-Implementation Hybrid Study: Health Care System Level Theoretical Considerations & Pragmatic Trial ResultsDr. Zatzick, PI of the TSOS effectiveness-implementation pragmatic clinical trial, presents the results and additional theoretical considerations.
  
6/4/2021Grand RoundsJulie Fritz; Amanda Petrik; Wendy Weber; Gloria Coronado; David WetterNIH; National Institutes of Health (NIH) the National Center for Complementary and Integrative Health (NCCIH); University of Utah; Kaiser Permanente Center for Health Research; Kaiser PermanenteInclusion of Diverse Participants in Pragmatic Clinical Trials: Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize DiversityPrincipal investigators of 2 Demonstration Projects discuss how to plan for and maximize clinical trial diversity through stakeholder engagement and site selection.
  
6/4/2021Grand RoundsJulie Fritz; Wendy Weber; David Wetter; Amanda Petrik; Gloria CoronadoKaiser Permanente Center for Health Research; Kaiser Permanente; NIH; National Institutes of Health (NIH) the National Center for Complementary and Integrative Health (NCCIH); University of UtahInclusion of Diverse Participants in Pragmatic Clinical Trials: Planning for Diversity – Stakeholder Engagement and Site Selection to Maximize Diversity Principal investigators of 2 Demonstration Projects discuss how to plan for and maximize clinical trial diversity through stakeholder engagement and site selection.
  
5/21/2021Grand RoundsChris Butler; Ben SavilleUniversity of Oxford; Berry ConsultantsThe PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and DeliveryDrs. Saville and Butler describe how the PRINCIPLE clinical trial employs an innovative adaptive platform to study COVID-19 treatments and outcomes.
  
5/21/2021Grand RoundsChris Butler; Ben SavilleUniversity of Oxford; Berry ConsultantsThe PRINCIPLE Adaptive Platform Trial for Community Treatment of COVID-19: Innovation in Trial Design and DeliveryDrs. Saville and Butler describe how the PRINCIPLE clinical trial employs an innovative adaptive platform to study COVID-19 treatments and outcomes.
  
5/14/2021Grand RoundsClyde YancyNorthwestern UniversityKeynote-Diverse Representation Among Clinical Trial Participants: Why It Is Important and How Can We ImproveDr. Yancy shares insights on the importance of diversity, not only among study participants but also in clinical trial leadership, and suggests concrete steps to advance diversity and change the way we evolve evidence in clinical trials.
  
5/14/2021Grand RoundsClyde YancyNorthwestern UniversityKeynote-Diverse Representation Among Clinical Trial Participants: Why It Is Important and How Can We ImproveDr. Yancy shares insights on the importance of diversity, not only among study participants but also in clinical trial leadership, and suggests concrete steps to advance diversity and change the way we evolve evidence in clinical trials.
  
5/7/2021Grand RoundsMegan RanneyBrown University School of Public Health; Brown University School of MedicineOnline Recruitment in the Era of COVID-19: Pitfalls and Progress Dr. Ranney discusses aspects of participant recruitment in clinical trials using social media and digital technologies during the COVID-19 pandemic.
  
5/7/2021Grand RoundsMegan RanneyBrown University School of Public Health; Brown University School of MedicineOnline Recruitment in the Era of COVID-19: Pitfalls and Progress Dr. Ranney discusses aspects of participant recruitment in clinical trials using social media and digital technologies during the COVID-19 pandemic.
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