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6/26/2020Grand RoundsKeith Marsolo; George Oliver; Rachel Richesson; Teresa Zayas-Cabán; Christopher LonghurstDuke University; The Office of the National Coordinator for Health Information Technology (ONC); Duke University School of Nursing; Parkland Center for Clinical Innovations; UC San Diego HealthAdvances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Keys to Success in the Evolving EHR Environment A panel of experts discusses experiences and challenges in advancing the use of electronic data in embedded pragmatic clinical trials.Coordinating CenterYes
  
6/26/2020Grand RoundsKeith Marsolo; Rachel Richesson; Teresa Zayas-Cabán; Christopher Longhurst; George OliverDuke University; Duke University School of Nursing; The Office of the National Coordinator for Health Information Technology (ONC); Parkland Center for Clinical Innovations; UC San Diego HealthAdvances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Keys to Success in the Evolving EHR Environment A panel of experts discusses experiences and challenges in advancing the use of electronic data in embedded pragmatic clinical trials.Coordinating CenterYes
  
6/19/2020Grand RoundsLiz Turner; Patrick Heagerty; David MurrayDuke University; NIH; University of WashingtonLiving Textbook Grand Rounds Series: Part 4-Demystifying Biostatistical Concepts for Embedded Pragmatic Clinical Trials Drs. Turner, Murray, and Heagerty describe statistical issues in study designs for embedded pragmatic clinical trials.Biostatistics and Study Design Core; Coordinating CenterYes
  
6/19/2020Grand RoundsLiz Turner; Patrick Heagerty; David MurrayDuke University; University of Washington; NIHLiving Textbook Grand Rounds Series: Part 4-Demystifying Biostatistical Concepts for Embedded Pragmatic Clinical Trials Drs. Turner, Murray, and Heagerty describe statistical issues in study designs for embedded pragmatic clinical trials.Biostatistics and Study Design Core; Coordinating CenterYes
  
6/12/2020Grand RoundsSusan MitchellHarvard Medical SchoolA Cluster Randomized Pragmatic Trial of an Advance Care Planning Video Intervention in Long-Stay Nursing Home Residents: Main Findings from the PROVEN Trial Dr. Mitchell presents findings from the PROVEN Trial, an NIH Collaboratory Demonstration Project that studied the effect of showing advance care planning videos to long-stay nursing home residents.PROVEN: Pragmatic Trial of Video Education in Nursing HomesYes
  
6/12/2020Grand RoundsSusan MitchellHarvard Medical SchoolA Cluster Randomized Pragmatic Trial of an Advance Care Planning Video Intervention in Long-Stay Nursing Home Residents: Main Findings from the PROVEN Trial Dr. Mitchell presents findings from the PROVEN Trial, an NIH Collaboratory Demonstration Project that studied the effect of showing advance care planning videos to long-stay nursing home residents.PROVEN: Pragmatic Trial of Video Education in Nursing HomesYes
  
6/5/2020Grand RoundsKeith Marsolo; Thomas Carton; Jason BlockDuke Clinical Research Institute; Duke University School of Medicine; Harvard Pilgrim Health Care Institute; PCORnet; Louisiana Public Health InstitutePCORnet COVID-19 Common Data Model Design and Results A panel of experts discusses how PCORnet’s Common Data Model is supporting infectious disease surveillance and research during the onset of the COVID-19 pandemic.Yes
  
6/5/2020Grand RoundsThomas Carton; Keith Marsolo; Jason BlockDuke Clinical Research Institute; Duke University School of Medicine; Harvard Pilgrim Health Care Institute; Louisiana Public Health Institute; PCORnetPCORnet COVID-19 Common Data Model Design and ResultsA panel of experts discusses how PCORnet’s Common Data Model is supporting infectious disease surveillance and research during the onset of the COVID-19 pandemic.Yes
  
5/29/2020Grand RoundsWendy Weber; Lynn DeBar; Jeffrey Jarvik; Vincent Mor; Douglas ZatzickNIH; Brown University School of Public Health; University of Washington; Kaiser Permanente Washington Health Research InstituteAdvances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Experiences from the Collaboratory PCTs A panel of experts shares knowledge and experiences learned from 4 NIH Collaboratory Demonstration Projects.LIRE: Lumbar Image with Reporting of Epidemiology; TSOS: A Policy-Relevant U.S. Trauma Care System Pragmatic Trial for PTSD and Comorbidity (Trauma Survivors Outcomes and Support); PROVEN: Pragmatic Trial of Video Education in Nursing Homes; PPACT: Collaborative Care for Chronic Pain in Primary CareYes
  
5/29/2020Grand RoundsJeffrey Jarvik; Lynn DeBar; Vincent Mor; Wendy Weber; Douglas ZatzickNIH; Kaiser Permanente Washington Health Research Institute; Brown University School of Public Health; University of WashingtonAdvances at the Intersection of Digital Health, Electronic Health Records, and Pragmatic Clinical Trials: Experiences from the Collaboratory PCTs A panel of experts shares knowledge and experiences learned from 4 NIH Collaboratory Demonstration Projects.LIRE: Lumbar Image with Reporting of Epidemiology; PROVEN: Pragmatic Trial of Video Education in Nursing Homes; PPACT: Collaborative Care for Chronic Pain in Primary Care; TSOS: A Policy-Relevant U.S. Trauma Care System Pragmatic Trial for PTSD and Comorbidity (Trauma Survivors Outcomes and Support)Yes
  
5/15/2020Grand RoundsDerek AngusUniversity of PittsburghOptimized Learning While Doing: The REMAP-CAP Adaptive Platform Trial Dr. Angus describes a global adaptive platform trial developed to determine and continuously update the optimal set of treatments for community-acquired pneumonia and other conditions.Yes
  
5/15/2020Grand RoundsDerek AngusUniversity of PittsburghOptimized Learning While Doing: The REMAP-CAP Adaptive Platform TrialDr. Angus describes a global adaptive platform trial developed to determine and continuously update the optimal set of treatments for community-acquired pneumonia and other conditions.Yes
  
5/8/2020Grand RoundsPatrick Heagerty; Jacqueline Corrigan-Curay; Joshua DennyUniversity of Washington; NIH; Food and Drug Administration (FDA); Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER)Real World Evidence: Contemporary Experience and Future DirectionsA panel of experts discuss current and future directions for generating real-world evidence (RWE) as illustrated by programs at the FDA and NIH.Yes
  
5/8/2020Grand RoundsJacqueline Corrigan-Curay; Joshua Denny; Patrick HeagertyUniversity of Washington; NIH; Food and Drug Administration (FDA); Food and Drug Administration's (FDA) Center for Drug Evaluation and Research (CDER)Real World Evidence: Contemporary Experience and Future DirectionsA panel of experts discuss current and future directions for generating real-world evidence (RWE) as illustrated by programs at the FDA and NIH.Yes
  
5/1/2020Grand RoundsRobert CaliffVerily Life Sciences; Google HealthCan the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem?Dr. Califf presents the keynote address for a special Grand Rounds webinar series on advances at the intersection of digital health, electronic health records, and pragmatic clinical trials.Coordinating CenterYes
  
5/1/2020Grand RoundsRobert CaliffGoogle Health; Verily Life SciencesCan the COVID-19 Crisis Lead to Reformation of the Evidence Generation Ecosystem? Dr. Califf presents the keynote address for a special Grand Rounds webinar series on advances at the intersection of digital health, electronic health records, and pragmatic clinical trialsCoordinating CenterYes
  
4/24/2020Grand RoundsMartin LandrayUniversity of OxfordThe RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 Dr. Landray describes a coordinated approach to the rapid establishment of a platform for the RECOVERY randomized trial evaluating four medications to treat COVID-19 in hospitalized adult patients.Yes
  
4/24/2020Grand RoundsMartin LandrayUniversity of OxfordThe RECOVERY Trial: A UK National Platform Trial of Potential Treatments for Patients Hospitalised with COVID-19 Dr. Landray describes a coordinated approach to the rapid establishment of a platform for the RECOVERY randomized trial evaluating four medications to treat COVID-19 in hospitalized adult patients.Yes
  
4/17/2020Grand RoundsJosephine Briggs; Susanna Naggie; Emily O'Brien; Russell Rothman; Nakela Cook; Christopher ForrestDuke University; PCORnet; Patient-Centered Outcomes Research Institute (PCORI); Academic Institution; Vanderbilt University; Children's Hospital of PennsylvaniaThe HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle EvidenceA panel discusses the HERO program, a new registry that unites healthcare workers across America in sharing their clinical and life experiences around COVID-19.Yes
  
4/17/2020Grand RoundsRussell Rothman; Christopher Forrest; Josephine Briggs; Nakela Cook; Emily O'Brien; Susanna NaggieChildren's Hospital of Pennsylvania; Duke University; Vanderbilt University; Patient-Centered Outcomes Research Institute (PCORI); PCORnetThe HERO Program: PCORnet® at Work to Create a Healthcare Worker Community for Rapid Cycle EvidenceA panel discusses the HERO program, a new registry that unites healthcare workers across America in sharing their clinical and life experiences around COVID-19.Yes
  
4/10/2020Grand RoundsSean CollinsVanderbilt University; Vanderbilt University Medical CenterHydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical Trial Dr. Collins discusses a new randomized clinical trial evaluating hydroxychloroquine for hospitalized adult patients with COVID-19.Yes
  
4/10/2020Grand RoundsSean CollinsVanderbilt University; Vanderbilt University Medical CenterHydroxychloroquine for the Early Treatment of COVID-19 in Hospitalized Adults: A Multicenter Randomized Clinical TrialDr. Collins discusses a new randomized clinical trial evaluating hydroxychloroquine for hospitalized adult patients with COVID-19.
  
4/3/2020Grand RoundsHarlan Krumholz; Graham Nichol; Bala HotaRush University; University of Washington; Yale New Haven HospitalInnovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research A panel discusses the work of the INSPIRE consortium to address the urgent need for evidence amid the COVID-19 pandemic.Yes
  
4/3/2020Grand RoundsHarlan Krumholz; Bala Hota; Graham NicholRush University; University of Washington; Yale New Haven HospitalInnovative Support for Patients with SARS-COV-2 Infections Registry (INSPIRE): Participant-Centered, Rapidly-Deployed, Digitally-Enabled Research A panel discusses the work of the INSPIRE consortium to address the urgent need for evidence amid the COVID-19 pandemic.Yes
  
3/27/2020Grand RoundsWendy WeberNIH; National Institutes of Health (NIH) the National Center for Complementary and Integrative Health (NCCIH)Living Textbook Grand Rounds Series: Part 3-Tips for Putting Together a Successful PCT Grant Application Dr. Weber presents best approaches to developing a successful grant application for embedded PCTs.Coordinating CenterYes
  
3/27/2020Grand RoundsWendy WeberNIHLiving Textbook Grand Rounds Series: Part 3-Tips for Putting Together a Successful PCT Grant Application Dr. Weber presents best approaches to developing a successful grant application for embedded PCTs.Coordinating CenterYes
  
3/20/2020Grand RoundsEric Perakslis; Adrian Hernandez; Susanna NaggieDuke University; Duke Clinical Research Institute; Duke ForgeClinical Trials in the Time of COVID-19 A Duke University panel discusses the impact of the COVID-19 outbreak on the conduct of clinical trials. Yes
  
3/20/2020Grand RoundsAdrian Hernandez; Eric Perakslis; Susanna NaggieDuke University; Duke Clinical Research Institute; Duke ForgeClinical Trials in the Time of COVID-19 A Duke University panel discusses the impact of the COVID-19 outbreak on the conduct of clinical trials. Coordinating CenterYes
  
3/13/2020Grand RoundsChristopher Granger; Abhinav SharmaDuke University; McGill UniversityImpact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions Drs. Sharma and Granger discuss aspects of the regulatory guidance for evaluating the cardiovascular risk of new glucose-lowering treatments for type 2 diabetes.Yes
  
3/13/2020Grand RoundsAbhinav Sharma; Christopher GrangerDuke University; McGill UniversityImpact of Regulatory Guidance on Evaluating Cardiovascular Risk of New Glucose-Lowering Therapies to Treat Type 2 Diabetes Mellitus–Lessons Learned and Future Directions Drs. Sharma and Granger discuss aspects of the regulatory guidance for evaluating the cardiovascular risk of new glucose-lowering treatments for type 2 diabetes.Yes
  
3/6/2020Grand RoundsLeora HorwitzNew York University School of MedicineCreating a Learning Health System Through Randomization Dr. Horwitz describes methods for using randomization in health system quality improvement (QI) initiatives to promote a learning healthcare system.Yes
  
3/6/2020Grand RoundsLeora HorwitzNew York University School of MedicineCreating a Learning Health System Through Randomization Dr. Horwitz describes methods for using randomization in health system quality improvement (QI) initiatives to promote a learning healthcare system.Yes
  
2/28/2020Grand RoundsLeah Tuzzio; Jeffrey Jarvik; Vincent MorUniversity of Washington; Kaiser Permanente Washington Health Research Institute; Brown University School of Public HealthLiving Textbook Grand Rounds Series: Part 2-Preparing for the Unknown: Conducting Pragmatic Research in Real-World ContextsAn expert panel discusses approaches to preparing, monitoring, and evaluating pragmatic clinical trials embedded in real-world clinical settings.Coordinating CenterYes
  
2/28/2020Grand RoundsLeah Tuzzio; Jeffrey Jarvik; Vincent MorBrown University School of Public Health; University of Washington; Kaiser Permanente Washington Health Research InstituteLiving Textbook Grand Rounds Series: Part 2-Preparing for the Unknown: Conducting Pragmatic Research in Real-World ContextsAn expert panel discusses approaches to preparing, monitoring, and evaluating pragmatic clinical trials embedded in real-world clinical settings.Yes
  
2/21/2020Grand RoundsSheana Bull; Michael HoUniversity of Colorado; University of Colorado School of Medicine; Department of Veterans AffairsNudge Study UpdatesDrs. Bull and Ho discuss the progress and challenges of the Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications (Nudge) Demonstration Project.Nudge: Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular MedicationsYes
  
2/21/2020Grand RoundsMichael Ho; Sheana BullUniversity of Colorado; University of Colorado School of Medicine; Department of Veterans AffairsNudge Study UpdatesDrs. Bull and Ho discuss the progress and challenges of the Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular Medications (Nudge) Demonstration Project.Nudge: Personalized Patient Data and Behavioral Nudges to Improve Adherence to Chronic Cardiovascular MedicationsYes
  
2/14/2020Grand RoundsDavid AtkinsDepartment of Veterans AffairsDo Our Current Research Models Meet the Needs of a Learning Health Care System? Dr. Atkins discusses how new research models and health system partnerships can advance a learning healthcare system.Yes
  
2/14/2020Grand RoundsDavid AtkinsDepartment of Veterans AffairsDo Our Current Research Models Meet the Needs of a Learning Health Care System? Dr. Atkins discusses how new research models and health system partnerships can advance a learning healthcare system.Yes
  
2/7/2020Grand RoundsMitesh PatelUniversity of PennsylvaniaUsing Nudges to Improve the Delivery of Health Care Dr. Patel discusses how nudges can be designed to help clinicians with evidence-based care decisions and help patients increase engagement and change health behaviors.Yes
  
2/7/2020Grand RoundsMitesh PatelUniversity of PennsylvaniaUsing Nudges to Improve the Delivery of Health Care Dr. Patel discusses how nudges can be designed to help clinicians with evidence-based care decisions and help patients increase engagement and change health behaviors.Yes
  
1/31/2020Grand RoundsGregory Simon; Lesley CurtisDuke Clinical Research Institute; Kaiser Permanente Washington Health Research InstituteLiving Textbook Grand Rounds Series Part 1-Pragmatic Clinical Trials: How Do I Start?Drs. Simon and Curtis discuss how PCTs are different and why we need them, and important things to consider when developing your pragmatic research question and engaging with stakeholders.Coordinating CenterYes
  
1/31/2020Grand RoundsLesley Curtis; Gregory SimonKaiser Permanente Washington Health Research Institute; Duke Clinical Research InstituteLiving Textbook Grand Rounds Series Part 1-Pragmatic Clinical Trials: How Do I Start? Drs. Simon and Curtis discuss how PCTs are different and why we need them, and important things to consider when developing your pragmatic research question and engaging with stakeholders.Coordinating CenterYes
  
1/24/2020Grand RoundsJustin EzekowitzUniversity of AlbertaCardiovascular Trials Over 2 Decades: Progress on Pragmatism? Dr. Ezekowitz describes recent progress in pragmatism in cardiovascular trials.Yes
  
1/24/2020Grand RoundsJustin EzekowitzUniversity of AlbertaCardiovascular Trials Over 2 Decades: Progress on Pragmatism? Dr. Ezekowitz describes recent progress in pragmatism in cardiovascular trials.Yes
  
1/17/2020Grand RoundsMurali MattaFood and Drug Administration (FDA)Assessment of the Human Systemic Absorption of Sunscreen Active Ingredients: FDA-Sponsored Randomized Clinical TrialDr. Matta describes recent assessments of systemic absorption of sunscreen active ingredients in an FDA-sponsored RCT.Yes
  
1/17/2020Grand RoundsMurali MattaFood and Drug Administration (FDA)Assessment of the Human Systemic Absorption of Sunscreen Active Ingredients: FDA-Sponsored Randomized Clinical TrialDr. Matta describes recent assessments of systemic absorption of sunscreen active ingredients in an FDA-sponsored RCT.Yes
  
1/10/2020Grand RoundsShivan MehtaUniversity of PennsylvaniaPragmatic Trials of Behavioral Economic Interventions to Increase Colorectal Cancer ScreeningDr. Mehta discusses how principles of behavioral economics can be used to help increase rates of colorectal cancer screening.Yes
  
1/10/2020Grand RoundsShivan MehtaUniversity of PennsylvaniaPragmatic Trials of Behavioral Economic Interventions to Increase Colorectal Cancer ScreeningDr. Mehta discusses how principles of behavioral economics can be used to help increase rates of colorectal cancer screening.Yes
  
12/13/2019Grand RoundsEdward Melnick; Gail D'OnofrioYale University School of MedicineEMBED Update: Challenges and SolutionsDrs. Melnick and D’Onofrio discuss challenges and solutions in their EMBED Demonstration Project.EMBED: Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use DisorderYes
  
12/13/2019Grand RoundsEdward Melnick; Gail D'OnofrioYale University School of MedicineEMBED Update: Challenges and SolutionsDrs. Melnick and D’Onofrio discuss challenges and solutions in their EMBED Demonstration Project.EMBED: Pragmatic Trial of User-Centered Clinical Decision Support to Implement EMergency Department-Initiated BuprenorphinE for Opioid Use DisorderYes
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