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Responding to signals of mental and behavioral health risk in pragmatic clinical trials: ethical obligations in a healthcare ecosystem1/5/2022Publication from the Ethics and Regulatory CoreJoseph Ali; Stephanie Morain; Pearl O'Rourke; Benjamin Wilfond; Emily O'Brien; Christina Zigler; Karen Staman; Kevin Weinfurt; Jeremy Sugarman
  
Leave me out: patients' characteristics and reasons for opting out of a pragmatic clinical trial involving medication adherence12/23/2021Publication from the Nudge Demonstration Project and the Ethics and Regulatory CoreLisa Sandy; Thomas Glorioso; Kevin Weinfurt; Jeremy Sugarman; Pamela Peterson; Russell Glasgow; Michael Ho
  
Validation of claims algorithms to identify Alzheimer's disease and related dementias12/17/2021Publication from the Distributed Research NetworkEllen McCarthy; Chiang-Hua Chang; Nicholas Tilton; Mohamed Bassyouni; Mohammed Kabeto; Kenneth Langa; Julie Bynum
  
Locating advance care planning documents in the electronic health record during emergency care12/8/2021Publication from the PRIM-ER Demonstration ProjectOlivia Pyles; Christopher Hritz; Peg Gulker; Jansi Straveler; Corita Grudzen; Cole Briggs; Lauren Southerland
  
Incentives and payments in pragmatic clinical trials: scientific, ethical, and policy considerations11/12/2021Publication from the Ethics and Regulatory CoreAndrew Garland; Kevin Weinfurt; Jeremy Sugarman
  
PPACT Main Outcome Paper11/2/2021PPACT Main Outcome PaperLynn DeBar; Meghan Mayhew; Lindsay Benes; Allison Bonifay; Richard Deyo; Charles Elder; Francis Keefe; Michael Leo; Carmit McMullen; Ashli Owen-Smith; David Smith; Connie Trinacty; William Vollmer
  
A prospective US national trauma center study of firearm injury survivors weapon carriage and posttraumatic stress disorder symptoms10/1/2021Publication from the TSOS Demonstration ProjectsDeepika Nehra; Eileen Bulger; Ronald Maier; Kathleen Moloney; Joan Russo; Jin Wang; Kristina Anderson; Douglas Zatzick
  
Enhancing the use of EHR systems for pragmatic embedded research: lessons from the NIH Health Care Systems Research Collaboratory10/1/2021Publication from the Electronic Health Records CoreRachel Richesson; Keith Marsolo; Brian Douthit; Karen Staman; Michael Ho; Dana Dailey; Andrew Boyd; Kathleen McTigue; Miriam Ezenwa; Judith Schlaeger; Crystal Patil; Keturah Faurot; Leah Tuzzio; Eric Larson; Emily O'Brien; Christina Zigler; Joshua Lakin; Alice Pressman; Jordan Braciszewski; Corita Grudzen; Guilherme Del Fiol
  
MOTIFS Publication: Identification and management of pragmatic clinical trial collateral findings: A current understanding and directions for future research9/29/2021Publication from the MOTIFS supplementStephanie Morain; Debra Mathews; Gail Geller; Juli Bollinger; Kevin Weinfurt; Jeffrey Jarvik; Elizabeth May; Jeremy Sugarman
  
Patient, provider, and clinic characteristics associated with opioid and non-opioid pain prescriptions for patients receiving low back imaging in primary care9/19/2021Publication from the LIRE Demonstration ProjectLaura Gold; Zachary Marcum; Eric Meier; Judith Turner; Kathryn James; David Kallmes; Patrick Luetmer; Brent Griffith; Karen Sherman; Janna Friedly; Pradeep Suri; Richard Deyo; Sandra Johnston; Andrew Avins; Patrick Heagerty; Jeffrey Jarvik
  
OPTIMUM Study Design Paper8/27/2021OPTIMUM Study Design PaperCarol Greco; Susan Gaylord; Kim Faurot; Janice Weinberg; Paula Gardiner; Isabel Roth; Jessica Barnhill; Holly Thomas; Sayali Dhamne; Christine Lathren; Jose Baez; Suzanne Lawrence; Tuhina Neogi; Karen Lasser; Maria Castro; Anna Marie White; Sandra Jean Simmons; Cleopatra Ferrao; Dhanesh Binda; Nandie Elhadidy; Kelly Eason; Kathleen McTigue; Natalia Morone
  
Zelen design clinical trials: why, when, and how8/17/2021Publication from the SPOT Demonstration ProjectGregory Simon; Susan Shortreed; Lynn DeBar
  
MOTIFS Publication: Patients' reactions to letters communicating collateral findings of pragmatic clinical trials: a national web-based survey8/12/2021Publication from the MOTIFS supplementKevin Weinfurt; Juli Bollinger; Elizabeth May; Gail Geller; Debra Mathews; Stephanie Morain; Lorrie Schmid; Diane Bloom; Jeremy Sugarman
  
Nudge Study Design Paper8/11/2021Nudge Study Design PaperRussell Glasgow; Christopher Knoepke; David Magid; Gary Grunwald; Thomas Glorioso; Joy Waughtal; Joel Marrs; Sheana Bull; Michael Ho
  
Catalyzing the translation of patient-centered research into United States trauma care systems: a case example8/1/2021Publication from the TSOS Demonstration ProjectDouglas Zatzick; Kathleen Moloney; Lawrence Palinkas; Peter Thomas; Kristina Anderson; Lauren Whiteside; Deepika Nehra; Eileen Bulger
  
The association between perceived electronic health record usability and professional burnout among US nurses7/30/2021Publication from the EMBED Demonstration ProjectEdward Melnick; Colin West; Bidisha Nath; Pamela Cipriano; Cheryl Peterson; Daniel Satele; Tait Shanafelt; Liselotte Dyrbye
  
Using the potential outcome framework to estimate optimal sample size for cluster randomized trials: a simulation-based algorithm7/15/2021Publication from the PROVEN Demonstration ProjectRuoshui Zhai; Roee Gutman
  
Natural language processing to identify advance care planning documentation in a multisite pragmatic clinical trial7/14/2021Publication from the ACP PEACE Demonstration ProjectCharlotta Lindvall; Chih-Ying Deng; Edward Mosely; Nicole Agaronnik; Areej El-Jawahri; Michael Paasche-Orlow; Joshua Lakin; Angelo Volandes; James Tulsky
  
Is learning worth the trouble? Improving health care system participation in embedded research6/26/2021Publication from the Coordinating CenterRichard Platt; Gregory Simon; Adrian Hernandez
  
Accounting for quality improvement during the conduct of embedded pragmatic clinical trials within healthcare systems: NIH Collaboratory case studies6/23/2021Publication from the Health Care Systems Interactions CoreLeah Tuzzio; Catherine Meyers; Laura Dember; Corita Grudzen; Edward Melnick; Karen Staman; Susan Huang; Julie Richards; Lynn DeBar; Miguel Vazquez; Beverly Green; Gloria Coronado; Jeffrey Jarvik; Michael Ho; Barbara Wells; Kathryn James; Eric Larson
  
Providing epidemiological data in lumbar spine imaging reports did not affect subsequent utilization of spine procedures: secondary outcomes from a stepped-wedge randomized controlled trial6/4/2021Publication from the LIRE Demonstration ProjectPradeep Suri; Eric Meier; Laura Gold; Zachary Marcum; Sandra Johnston; Kathryn James; Brian Bresnahan; Michael O'Reilly; Judith Turner; David Kallmes; Karen Sherman; Richard Deyo; Patrick Luetmer; Andrew Avins; Brent Griffith; Patrick Heagerty; Sean Rundell; Jeffrey Jarvik; Janna Friedly
  
Acupuncture for chronic pain in adults with sickle cell disease: a mixed-methods pilot study6/3/2021Publication from the GRACE Demonstration ProjectRobert Molokie; Judith Schlaeger; Hongjin Li; Crystal Patil; Franklin Njoku; Alana Steffen; Ardith Doorenbos
  
Nudge me: tailoring text messages for prescription adherence through N-of-1 interviews6/3/2021Publication from the Nudge Demonstration ProjectJoy Waughtal; Phat Luong; Catia Chavez; Michael Ho; Sheana Bull
  
Acupuncture intervention protocol: consensus process for a pragmatic randomized controlled trial of acupuncture for management of chronic low back pain in older adults: an NIH Heal Initiative funded project5/26/2021Publication from the BackInAction Demonstration ProjectKaren Sherman; Arja Nielsen; Laura Ocker; Iman Majd; Jeff Draisin; Katherine Taromina; Marjorie Maggenti; Jaimie Long; Mark Nolting
  
Text message medication adherence reminders automated and delivered at scale across two institutions: testing the Nudge system: pilot study5/17/2021Publication from the Nudge Demonstration ProjectPhat Luong; Larry Allen; Joy Waughtal; Lisa Sandy; Michael Ho; Sheana Bull; Thomas Glorioso; Gary Grunwald; Pamela Peterson; Amber Khanna
  
Brief interventions via electronic health record messaging for population-based suicide prevention: mixed methods pilot study4/12/2021Publication from the SPOT Demonstration ProjectUrsula Whiteside; Julie Richards; Gregory Simon
  
A yet unrealized promise: structured advance care planning elements in the electronic health record4/7/2021Publication from the ACP PEACE Demonstration ProjectJoshua Lakin; Daniel Gundersen; Charlotta Lindvall; Michael Paasche-Orlow; James Tulsky; Elise Brannen; Angelo Volandes; Kathryn Pollak; Danielle Kennedy; Jody-Ann McLeggon; Jeremiah Stout
  
Identifying prescribing cascades in Alzheimer's disease and related dementias: the calcium channel blocker-diuretic prescribing cascade3/23/2021Publication from the Distributed Research NetworkSonal Singh; Noelle Cocoros; Kevin Haynes; Vinit Nair; Thomas Harkins; Paula Rochon; Richard Platt; Inna Dashevsky; Juliane Reynolds; Kathleen Mazor; Sarah Bloomstone; Kathryn Anzuoni; Sybil Crawford; Jerry Gurwitz
  
Emergency department visits for nonfatal opioid overdose during the COVID-19 pandemic across 6 US healthcare systems3/19/2021Publication from the EMBED Demonstration ProjectWilliam Soares; Edward Melnick; Bidisha Nath; Gail D'Onofrio; Hyung Paek; Rachel Skains; Jason Hoppe; Molly Jeffery; Lauren Walter; Martin Casey; Anthony Napoli
  
Reconciling statistical and clinicians' predictions of suicide risk3/11/2021Publication from the SPOT Demonstration ProjectGregory Simon; Bridget Matarazzo; Colin Walsh; Jordan Smoller; Edwin Boudreaux; Bobbi Yarborough; Susan Shortreed; R. Yates Coley; Brian Ahmedani; Riddhi Doshi; Leah Harris; Michael Schoenbaum
  
TSOS Main Outcome Paper3/10/2021TSOS Main Outcome PaperDouglas Zatzick; Gregory Jurkovich; Patrick Heagerty; Joan Russo; Doyanne Darnell; Lea Parker; Michelle Roberts; Rddhi Moodliar; Allison Engstrom; Eileen Bulger; Lauren Whiteside; Deepika Nehra; Lawrence Palinkas; Kathleen Moloney; Jin Wang; Ronald Maier
  
Clinical outcomes of patients hospitalized with coronavirus disease 2019 (COVID-19) in Boston2/24/2021Publication from the ACP PEACE Demonstration ProjectAreej El-Jawahri; Michael Paasche-Orlow; Joshua Lakin; Annemarie Forrest; Elise Brannen; Angelo Volandes; Hacho Bohossian; Connor Johnson; Zara Cooper; Annemarie Jagielo; Matthew Reynolds; Kathleen Coogan; Dagny Vaughn
  
Effects of including epidemiologic data in lumbar spine imaging reports on prescribing non-opioid medications for pain2/8/2021Publication fromt the LIRE Demonstration ProjectZachary Marcum; Laura Gold; Kathryn James; Eric Meier; Judith Turner; David Kallmes; Daniel Cherkin; Richard Deyo; Karen Sherman; Patrick Luetmer; Andrew Avins; Brent Griffith; Janna Friedly; Pradeep Suri; Patrick Heagerty; Jeffrey Jarvik
  
Leveraging a health information exchange to examine the accuracy of self-report emergency department utilization data among hospitalized injury survivors1/28/2021Publication from the TSOS Demonstration ProjectLauren Whiteside; Joan Russo; Deepika Nehra; Kathleen Moloney; Douglas Zatzick; Marie Vrablik; Eileen Bulger
  
Antidopaminergic-antiparkinsonian medication prescribing cascade in persons with Alzheimer's disease1/11/2021Publication from the Distributed Research Network ADRD supplementSonal Singh; Noelle Cocoros; Kevin Haynes; Vinit Nair; Paula Rochon; Richard Platt; Sarah Bloomstone; Kathryn Anzuoni; Jerry Gurwitz; Thomas Harkins; Inna Dashevsky; Juliane Reynolds; Kathleen Mazor; Sybil Crawford
  
Perceived electronic health record usability as a predictor of task load and burnout among US physicians: mediation analysis12/22/2020Publication from the EMBED Demonstration ProjectEdward Melnick; Elizabeth Harry; Christine Sinsky; Liselotte Dyrbye; Hanhan Wang; Mickey Todd Trockel; Colin West; Tait Shanafelt
  
HiLo Study Design Paper12/3/2020HiLo Study Design PaperDaniel Edmonston; Tamara Isakova; Laura Dember; Steven Brunelli; Amy Young; Rebecca Brosch; Srinivasan Beddhu; Hrishikesh Chakraborty; Myles Wolf
  
Impact of an advance care planning video intervention on care of short-stay nursing home patients11/7/2020Publication from the PROVEN Demonstration ProjectLacey Loomer; Jessica Ogarek; Susan Mitchell; Angelo Volandes; Roee Gutman; Pedro Gozalo; Ellen McCreedy; Vincent Mor
  
Prescribing cascades in persons with Alzheimer's disease: engaging patients, caregivers, and providers in a qualitative evaluation of print educational materials10/30/2020Publication from the Distributed Research NetworkSarah Bloomstone; Kathryn Anzuoni; Noelle Cocoros; Jerry Gurwitz; Kevin Haynes; Vinit Nair; Richard Platt; Paula Rochon; Sonal Singh; Kathleen Mazor
  
Effectiveness and reach of the Primary Palliative Care for Emergency Medicine (PRIM-ER) Pilot Study: a qualitative analysis10/27/2020Publication from the PRIM-ER Demonstration ProjectFrank Chung; Sarah Turecamo; Allison Cuthel; Corita Grudzen
  
Factors influencing implementation of a colorectal cancer screening improvement program in community health centers: an applied use of configurational comparative methods10/26/2020Publication from the STOP CRC Demonstration ProjectAmanda Petrik; Beverly Green; Jennifer Schneider; Edward Miech; Jennifer Coury; Sally Retecki; Gloria Coronado
  
Rapid ethnographic assessment of the COVID-19 pandemic April 2020 'surge' and its impact on service delivery in an acute care medical emergency department and trauma center10/20/2020Publication from the TSOS Demonstration ProjectLawrence Palinkas; Lauren Whiteside; Deepika Nehra; Allison Engstrom; Mark Taylor; Kathleen Moloney; Douglas Zatzick
  
ACP PEACE Study Redesign (Details)10/7/2020This document describes changes to the ACP PEACE stepped-wedge study design to address effects caused by the onset of COVID-19.Angelo Volandes; James Tulsky
  
Estimating the number of self-harm events not identified by encounter diagnoses in health records9/25/2020Preprint from the SPOT Demonstration ProjectGregory Simon; Susan Shortreed; Jennifer Boggs; Gregory Clarke; Rebecca Rossom; Julie Richards; Arne Beck
  
Disseminating trial results: we can have both faster and better9/24/2020Publication from the NIH Collaboratory Coordinating CenterGregory Simon; Rachel Richesson; Adrian Hernandez
  
Ethical and regulatory concerns in pragmatic clinical trial monitoring and oversight 9/16/2020Publication from the TSOS Demonstration Project and the Ethics and Regulatory CoreMichelle Roberts; Dylan Fisher; Lea Parker; Doyanne Darnell; Jeremy Sugarman; Judith Carrithers; Kevin Weinfurt; Gregory Jurkovich; Douglas Zatzick
  
Identifying multisite chronic pain with electronic health records data9/11/2020Publication from the PPACT Demonstration ProjectMichael Von Korff; Lynn DeBar; Richard Deyo; Meghan Mayhew; Robert Kerns; Joseph Goulet; Cynthia Brandt
  
LIRE Main Outcome Paper9/4/2020LIRE Main Outcome PaperJeffrey Jarvik; Eric Meier; Kathryn James; Laura Gold; Katherine Tan; Larry Kessler; Pradeep Suri; David Kallmes; Daniel Cherkin; Richard Deyo; Karen Sherman; Safwan Halabi; Bryan Comstock; Patrick Luetmer; Andrew Avins; Sean Rundell; Brent Griffith; Janna Friedly; Danielle Lavallee; Kari Stephens; Judith Turner; Brian Bresnahan; Patrick Heagerty
  
The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises9/1/2020Publication from the FM-TIPS Demonstration ProjectSrinivasa Raja; Daniel Carr; Milton Cohen; Nanna Finnerup; Herta Flor; Stephen Gibson; Francis Keefe; Jeffrey Mogil; Matthias Ringkamp; Kathleen Sluka; Xue-Jun Song; Bonnie Stevens; Mark Sullivan; Perri Tutelman; Takahiro Ushida; Kyle Vader
  
MOTIFS Publication: Stakeholder perspectives regarding pragmatic clinical trial collateral findings8/28/2020Publication from the MOTIFS supplementStephanie Morain; Stephanie Startz; Debra Mathews; Kevin Weinfurt; Elizabeth May; Juli Bollinger; Gail Geller; Jeremy Sugarman
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