​​​​Welcome to the IMPACT Knowledge Repository, a searchable collection of resources related to pragmatic clinical trials for people living with dementia and their caregivers. For additional content and information visit the IMPACT Collaboratory.

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IMPACT Grand Rounds 57: Meta Lessons Learned from Pilot and Demonstration Projects Implementation (Video)6/12/2025Grand Rounds/Webinars
(Video) In Grand Rounds 57, Jennifer Sullivan, PhD, describes lessons learned from IMPACT Pilot and Demonstration Projects implementation data.
IMPACT Grand Rounds 57: Meta Lessons Learned from Pilot and Demonstration Projects Implementation (Slides)6/12/2025Grand Rounds/Webinars
(Slides) In Grand Rounds 57, Jennifer Sullivan, PhD, describes lessons learned from IMPACT Pilot and Demonstration Projects implementation data.
Invested Partner Feedback on Technology Assistance in Dementia (Tech-AiD)6/11/2025Publications/Articles
(Article) Investigators conducted a multimethod study to collect feedback from care partners and healthcare professionals about a manualized behavioral intervention called Technology Assistance in Dementia (Tech-AiD) intended to improve care of people living with Alzheimer's disease and related dementias while also reducing burden among care partners.
Enhancing Interpretation of Cognitive Changes in Alzheimer’s Intervention Trials: Application of Standardized Regression-Based Change Scores5/25/2025Publications/Articles
(Article) Investigators test the use of standardized regression-based (SRB) change indices to understand equivocal  trial results in behavioral interventions.
IMPACT Grand Rounds 56: Bridging Research and Practice: An Update from Real World Data Scholars (Slides)5/15/2025Grand Rounds/Webinars
(Slides) In Grand Rounds 56, the 2023 Real World Data Scholars, Jinying Chen, PhD, Kenneth Lam, MD, MAS, Lindsay White, PhD, and Yongkang Zhang, PhD, MS, presented on their research projects using the Long-Term Care (LTC) Data Cooperative dataset.
Incidence of Long COVID diagnoses in 3.6 million US Medicare beneficiaries with COVID-195/15/2025Publications/Articles
(Article) This cohort study of 3,588,671 Medicare beneficiaries with COVID-19 explores the incidence of Long COVID among older adults and whether that incidence varies across clinical subgroup and vaccination history.
IMPACT Grand Rounds 56: Bridging Research and Practice: An Update from Real World Data Scholars (Video)5/15/2025Grand Rounds/Webinars
(Video) In Grand Rounds 56, the 2023 Real World Data Scholars, Jinying Chen, PhD, Kenneth Lam, MD, MAS, Lindsay White, PhD, and Yongkang Zhang, PhD, MS, presented on their research projects using the Long-Term Care (LTC) Data Cooperative dataset.
Emergency Department Utilization Among Co-Residing Family Caregivers of Persons Living With Dementia5/10/2025Publications/Articles
(Article) Results from an observational cohort study of emergency department visits among caregivers of people living with dementia that live with the PLWD compared to the same of caregivers that do not live with the PLWD.
External Validation of a Proprietary Risk Model for One-Year Mortality in Community-Dwelling Adults 65 Years or Older4/29/2025Publications/Articles
(Article) Investigators conduct a retrospective cohort study examining the discrimination, calibration, and algorithmic fairness of the Epic End-of-Life Care Index (EOL-CI).  The EOL-CI is a proprietary risk model for one-year mortality that is integrated into the electronic health record (EHR) at many health systems but to date there have been no external validation studies performed to examine its’ performance in community-dwelling populations.
Leveraging data, technology, and policy to address disparities for persons living with Alzheimer's disease and Alzheimer's disease related dementias4/29/2025Publications/Articles
(Article) Authors highlight important gaps and opportunities in work addressing disparities related to Alzheimer's disease and Alzheimer's disease related dementias (AD/ADRD) presented during Session 4: Disparities in Health Care Access, Utilization, and Quality, of the 2023 National Research Summit on Care, Services, and Supports for Persons Living with Dementia and Their Care Partners/Caregivers.
Detection and differentiation of undiagnosed dementia in the emergency department: A pilot referral pathway4/21/2025Publications/Articles
(Article) Results of a pilot study which tested the feasibility of ED clinicians referring older adult patients identified through CI screening and direct clinician referral for outpatient cognitive evaluation.
Grand Rounds 55: Augmenting Nurse Support and Electronic Health Record (EHR) Integration for the Pragmatic Trial of the TabCAT-Brain Health Assessment (TabCAT-BHA) (Slides)4/17/2025Grand Rounds/Webinars
(Slides) In this Grand Rounds, Katherine Possin, PhD, discusses "Augmenting Nurse Support and Electronic Health Record (EHR) Integration for the Pragmatic Trial of the TabCAT Brain Health Assessment (TabCAT-BHA)." TabCAT-BHA is a software platform owned by UCSF to provide diagnosis in MCI and dementia.
Grand Rounds 55: Augmenting Nurse Support and Electronic Health Record (EHR) Integration for the Pragmatic Trial of the TabCAT-Brain Health Assessment (TabCAT-BHA) (Video)4/17/2025Grand Rounds/Webinars
(Video) In this Grand Rounds, Katherine Possin, PhD, discusses "Augmenting Nurse Support and Electronic Health Record (EHR) Integration for the Pragmatic Trial of the TabCAT Brain Health Assessment (TabCAT-BHA)." TabCAT-BHA is a software platform owned by UCSF to provide diagnosis in MCI and dementia.
"There Should Be A Nurse On Call”: Complex Care Needs of Low-Income Older Adults in Medicaid-Supported Assisted Living4/10/2025Publications/Articles
(Article) The objective of this study was to explore the complex care needs and serious illness communication challenges experienced by low-income older adults in Medicaid-supported assisted living. Methods: A qualitative secondary framework analysis was conducted on data from a parent qualitative study involving 17 residents aged 60 and older with serious illnesses at a Medicaid-supported facility in New York City.
Grand Rounds 54: 5-Cog Paradigm to Improve Detection of Cognitive Impairment in Primary Care: Pragmatic Clinical Trial (Slides)3/20/2025Grand Rounds/Webinars
(Slides) In this Grand Rounds, Malaz Boustani, MD, MPH, discusses transforming brain health with early detection of cognitive problems in the primary care setting using the 5-cog paradigm.
Grand Rounds 54: 5-Cog Paradigm to Improve Detection of Cognitive Impairment in Primary Care: Pragmatic Clinical Trial (Video)3/20/2025Grand Rounds/Webinars
(Video) In this Grand Rounds, Malaz Boustani, MD, MPH, discusses transforming brain health with early detection of cognitive problems in the primary care setting using the 5-cog paradigm.
Key Informants’ Perceptions of Telehealth Palliative Care for People Living with Dementia in Nursing Homes3/19/2025Publications/Articles
(Article) A pilot ePCT of a telehealth palliative care program for nursing home residents living with dementia explores implementation barriers and facilitators.
Nonpharmacological Pain Management for People with Dementia: A Scoping Review Mapping Research Gaps from a Pragmatic Lens3/7/2025Publications/Articles
(Article) A scoping review of research studies of nonpharmacological pain interventions use and effectiveness with people living with dementia.   Eighty one studies covering 24 interventions were reviewed and mapped to the 9 domains of the Readiness Assessment for Pragmatic Trials (RAPT) model to summarize and identify research gaps.
An educational intervention to promote central nervous system-active deprescribing in dementia: A pilot study3/1/2025Publications/Articles
(Article) Results from IMPACT-funded pilot trial assessing the implementation feasibility and preliminary effectiveness of a patient nudge intervention to prompt deprescribing among people living with dementia (PLWD)  with CNS-active  polypharmacy.
How Do Researchers Identify and Recruit Dementia Caregivers? A Scoping Review2/5/2025Publications/Articles
(Article) This scoping review aimed to capture the current methodology for identifying and recruiting dementia caregivers in clinical studies.
Aligning Medications With What Matters Most: Conversations Between Pharmacists, People With Dementia, and Care Partners2/3/2025Publications/Articles
(Article) Investigators conducted a qualitative study of interactions between pharmacists and 55 patient care partner dyads in a secondary analysis of a pilot study of a pharmacist-led deprescribing intervention for people living with dementia in primary care.
Grand Rounds 52: Improving Advance Care Planning for Seriously Ill Primary Care Patients: UC Health Care Planning Study (Video)1/16/2025Grand Rounds/Webinars
(Video) In this Grand Rounds, Rebecca Sudore, MD, and Anne Walling, MD, PhD, discuss the evolving Advance Care Planning (ACP) definition and research along with lessons learned from their ACP PCORI pragmatic randomized control trial.
Grand Rounds 52: Improving Advance Care Planning for Seriously Ill Primary Care Patients: UC Health Care Planning Study (Slides)1/16/2025Grand Rounds/Webinars
(Slides) In this Grand Rounds, Rebecca Sudore, MD, and Anne Walling, MD, PhD, discuss the evolving Advance Care Planning (ACP) definition and research along with lessons learned from their ACP PCORI pragmatic randomized control trial.
Randomized in error in pragmatic clinical trials1/1/2025Publications/Articles
(Article) Differential exclusion in pragmatic clinical trials after randomization can lead to selection bias.  Under the potential outcomes framework, investigators evaluated the feasibility of using a Bayesian model to identify the randomized-in-error status and estimate the average treatment effect among participants not randomized in error.
Comprehensive Dementia Care Models: State of the Science and Future Directions1/1/2025Publications/Articles
(Article) The current Annual State of the Science Review provides an overview of the current state of comprehensive dementia care models in the United States and relevant policies. Challenges and opportunities for nursing education, research, and implementation across the translational research continuum are also outlined.
Grand Rounds 51: COVID Vaccination among Medicare Beneficiaries: Findings from an IMPACT Supplement (Slides)12/19/2024Grand Rounds/Webinars
(Slides) In this Grand Rounds, Kaley Hayes, PharmD, PhD & Daniel Harris, PhD, MPH discuss the COVid VAXines Effects on the Aged (COVVAXAGE) database, which was the first project with NIA LINKAGE program (external data linkage to CMS data in NIA-funded projects); they walk through associated papers and lessons learned working with industry partners CVS and Walgreens.
Grand Rounds 51: COVID Vaccination among Medicare Beneficiaries: Findings from an IMPACT Supplement (Video)12/19/2024Grand Rounds/Webinars
(Video) In this Grand Rounds, Kaley Hayes, PharmD, PhD & Daniel Harris, PhD, MPH discuss the COVid VAXines Effects on the Aged (COVVAXAGE) database, which was the first project with NIA LINKAGE program (external data linkage to CMS data in NIA-funded projects); they walk through associated papers and lessons learned working with industry partners CVS and Walgreens.
"What Matters" in the Emergency Department: A Prospective Analysis of Older Adults' Concerns and Desired Outcomes12/1/2024Publications/Articles
(Article) Researchers performed a secondary analysis of a multicenter prospective observational study as part of the 4Ms framework identifying "What Matters" to older adults seeking emergency department care and to identify patient characteristics associated with meeting desired outcomes.
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