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| | IMPACT on Alzheimer's (Video) | Featured Videos | 9/10/2019 | (Video) The National Institute on Aging (NIA) has awarded a five-year grant expected to total $53.4 million to Brown University and Boston-based Hebrew SeniorLife (HSL) to lead a nationwide effort to improve health care and quality of life for people living with Alzheimer’s disease and related dementias, as well as their caregivers. |
| | Overview of the 2019 Pilot Awards RFA (Video) | Grand Rounds/Webinars | 10/2/2019 | (Video) This webinar describes the goals and requirements to submit a proposal for 2019 NIA IMPACT Collaboratory Pilot Awards. |
| | Sociocultural Aspects and Determinants of Care for Alzheimer’s Disease and Related Dementias (ADRD) among Minority Ethnic Populations | Publications/Articles | 10/17/2019 | (Article) This paper was commissioned for the Workshop on Challenging Questions about Epidemiology, Care, and Caregiving for People with Alzheimer’s Disease and Related Dementias and their Families. The workshop was convened by the Board on Behavioral, Cognitive, and Sensory Sciences on October 17, 2019, in Washington, DC with support from the National Institute on Aging. Opinions and statements included in the paper are solely those of the individual author, and are not necessarily adopted, endorsed, or verified as accurate by the Board on Behavioral, Cognitive, and Sensory Sciences or the National Academy of Sciences, Engineering, and Medicine. |
| | What Can We Really Expect to Learn from a Pilot Study? | Other | 11/12/2019 | In this blog post, IMPACT member Keith Goldfeld, DrPH, MS, MPA, shares what researchers can realistically expect to learn from a relatively small pilot study of a new intervention. |
| | Grand Rounds 1: Are You Ready for a Pragmatic Trial? The RAPT Model and Implementation Considerations (Slides) | Grand Rounds/Webinars | 11/21/2019 | (Slides) In this Grand Rounds, Laura Gitlin, PhD, FGSA, FAAN, Rosa Baier, MPH, Joe Gaugler, PhD, and Eric Jutkowitz, PhD, present on the use of the Readiness Assessment for Pragmatic Trials (RAPT) model to assess an intervention’s readiness for an embedded pragmatic clinical trial (ePCT). The presenters describe the model's creation, domains, and scoring criteria, an the provide an example of its application to iterative phases of a pragmatic study. |
| | Grand Rounds 1: Are You Ready for a Pragmatic Trial? The RAPT Model and Implementation Considerations (Video) | Grand Rounds/Webinars | 11/21/2019 | (Video) This Grand Rounds webinar focuses on the Readiness Assessment for Pragmatic Trials (RAPT) model to assess an intervention’s readiness for an embedded pragmatic clinical trial (ePCT). RAPT includes nine domains that reflect a range of considerations regarding the feasibility of successfully employing pragmatic methods and the prospect of an intervention’s widespread adoption, if proven effective. Researchers using RAPT to evaluate an intervention are asked to qualitatively assess each domain from low to high readiness and can use the results to inform team discussion about when and how to proceed with an ePCT. In this session, we describe the model’s creation, domains, and scoring criteria, and then provide an example of its application to iterative phases of a pragmatic study. |
| | Podcast 1: Continuing the discussion of the RAPT Model | Podcasts | 12/10/2019 | In this podcast, IMPACT Collaboratory PI Susan Mitchell, MD, MPH, continues the Grand Rounds discussion with Rosa Baier, MPH, and Eric Jutkoqitz, PhD, about the RAPT Model and how it can help researchers determine a project’s readiness for a pragmatic trial. |
| | Podcast 1: Continuing the discussion of the RAPT Model (Transcript) | Podcasts | 12/10/2019 | (Transcript) In this podcast, IMPACT Collaboratory PI Susan Mitchell, MD, MPH, continues the Grand Rounds discussion with Rosa Baier, MPH, and Eric Jutkoqitz, PhD, about the RAPT Model and how it can help researchers determine a project’s readiness for a pragmatic trial. |
| | Grand Rounds 2: Stepped Wedge Cluster Randomized Trials: What, How, And When? (Slides) | Grand Rounds/Webinars | 12/19/2019 | (Slides) In this Grand Rounds, Monica Taljaard, PhD, focuses on the use of stepped wedge design in cluster randomized trials (SW-CRT). SW-CRT is a novel research design embraced by clinical researchers. It is unique from conventional parallel arm CRTs in that all clusters receive the intervention. The three main types of SW-CRT designs are presented, along with common justifications for employing these designs and their implications. |
| | Grand Rounds 2: Stepped Wedge Cluster Randomized Trials: What, How, And When? (Video) | Grand Rounds/Webinars | 12/19/2019 | (Video) In this Grand Rounds, Monica Taljaard, PhD, focuses on the use of stepped wedge design in cluster randomized trials (SW-CRT). SW-CRT is a novel research design embraced by clinical researchers. It is unique from conventional parallel arm CRTs in that all clusters receive the intervention. The three main types of SW-CRT designs are presented, along with common justifications for employing these designs and their implications. |
| | Podcast 2: Continuing the conversation on stepped wedge cluster trials: what, how and when? | Podcasts | 1/6/2020 | In this podcast, IMPACT Collaboratory PI Vince Mor, PhD, continues the Grand Rounds discussion with Monica Taljaard, PhD, about stepped wedge cluster randomized trials. |
| | Podcast 2: Continuing the conversation on stepped wedge cluster trials: what, how and when? (Transcript) | Podcasts | 1/6/2020 | (Transcript) In this podcast, IMPACT Collaboratory PI Vince Mor, PhD, continues the Grand Rounds discussion with Monica Taljaard, PhD, about stepped wedge cluster randomized trials. |
| | Grand Rounds 3: Using a Pilot to Test and Refine Your Measurement Strategy (Slides) | Grand Rounds/Webinars | 1/23/2020 | (Slides) In this Grand Rounds, Ellen McCreedy, PhD, MPH, uses a case example to describe how a pilot can be used to test the adequacy of existing data for evaluating an ePCT outcome. Dr. McCreedy also describes a potentially efficient ePCT design that accommodates under-detection in existing data while maintaining large-scale implementation and evaluation. |
| | Grand Rounds 3: Using a Pilot to Test and Refine Your Measurement Strategy (Video) | Grand Rounds/Webinars | 1/23/2020 | (Video) In this Grand Rounds, Ellen McCreedy, PhD, MPH, uses a case example to describe how a pilot can be used to test the adequacy of existing data for evaluating an ePCT outcome. Dr. McCreedy also describes a potentially efficient ePCT design that accommodates under-detection in existing data while maintaining large-scale implementation and evaluation. |
| | Podcast 3: Continuing the Conversation on Using a Pilot to Test and Refine Your Measurement Strategy | Podcasts | 2/3/2020 | In this podcast, IMPACT Collaboratory PI Susan Mitchell, MD, MPH, continues the Grand Rounds discussion with Ellen McCreedy, PhD, about using a pilot to test and refine measurement strategy. |
| | Podcast 3: Continuing the Conversation on Using a Pilot to Test and Refine Your Measurement Strategy (Transcript) | Podcasts | 2/3/2020 | (Transcript) In this podcast, IMPACT Collaboratory PI Susan Mitchell, MD, MPH, continues the Grand Rounds discussion with Ellen McCreedy, PhD, about using a pilot to test and refine measurement strategy. |
| | Analysing an Open Cohort Stepped-Wedge Clustered Trial with Repeated Individual Binary Outcomes | Other | 2/4/2020 | In this blog post, IMPACT member Keith Goldfeld, DrPH, MS, MPA, discusses how to analyze data from a stepped-wedge designed cluster randomized trial. |
| | Mission Moment: Marie Martinez Israelite, MSW (Video) | Featured Videos | 2/7/2020 | (Video) The mission of the NIA IMPACT Collaboratory is to build the nation’s capacity to conduct pragmatic clinical trials of interventions embedded within health care systems for people living with dementia and their care partners. Our Mission Moments highlight the perspective of someone directly involved with dementia to remind us of the importance of our mission. In this Mission Moment, we hear from Marie Martinez Israelite, MSW, Director of Victim Services at the Human Trafficking Institute and care partner for her mother, a retired physician who is living with Alzheimer’s. Ms. Israelite spoke at the NIA IMPACT Steering Committee meeting in January 2020. |
| | The NIA IMPACT Collaboratory Dissemination and Implementation Core (Video) | Featured Videos | 2/10/2020 | (Video) The NIA IMPACT Collaboratory Dissemination and Implementation Core helps researchers to take their findings beyond journals to help make a difference in dementia care. Learn more from Core Leader Laura Gitlin. |
| | Clustered Randomized Trials and the Design Effect | Other | 2/18/2020 | In this blog post, IMPACT member Keith Goldfeld, DrPH, MS, MPA, discusses the concept of design effect--a value that helps quantify how much information is lost or gained when individual outcomes in a group are correlated in a clustered randomized trial. |
| | Grand Rounds 4: Modifications and waivers of informed consent in pragmatic clinical trials (Slides) | Grand Rounds/Webinars | 2/20/2020 | (Slides) In this Grand Rounds, Jason Karlawish, MD, discusses waivers and alterations of written informed consent in pragmatic clinical trials, focusing on regulatory criteria addressing acceptable levels of research risk, the practicability of conducting the research with vs without informed consent, and efforts to respect the rights and welfare of people living with dementia. |
| | Grand Rounds 4: Modifications and waivers of informed consent in pragmatic clinical trials (Video) | Grand Rounds/Webinars | 2/20/2020 | (Video) In this Grand Rounds, Jason Karlawish, MD, discusses waivers and alterations of written informed consent in pragmatic clinical trials, focusing on regulatory criteria addressing acceptable levels of research risk, the practicability of conducting the research with vs without informed consent, and efforts to respect the rights and welfare of people living with dementia. |
| | Podcast 4: Continuing the conversation on Modifications and Waivers of Informed Consent in Pragmatic Clinical Trials | Podcasts | 2/20/2020 | In this podcast, IMPACT Collaboratory PI Vince Mor, PhD, continues the Grand Rounds discussion with Jason Karlawish, MD, about modifications and waivers of informed consent in pragmatic clinical trials. |
| | Podcast 4: Continuing the conversation on Modifications and Waivers of Informed Consent in Pragmatic Clinical Trials (Transcript) | Podcasts | 2/20/2020 | (Transcript) In this podcast, IMPACT Collaboratory PI Vince Mor, PhD, continues the Grand Rounds discussion with Jason Karlawish, MD, about modifications and waivers of informed consent in pragmatic clinical trials. |
| | An Introduction to the NIA IMPACT Collaboratory (Video) | Featured Videos | 2/21/2020 | (Video) Richard J. Hodes, MD, Director of the National Institute of Aging and Partha Bhattacharyya, PhD, the IMPACT Collaboratory Project Officer and Program Director in the Division of Behavioral and Social Research, share their thoughts on the need for the IMPACT Collaboratory and the project goals. |
| | The NIA IMPACT Regulation and Ethics Core (Video) | Featured Videos | 2/25/2020 | (Video) The Regulation and Ethics Core focuses on clarifying the balance among the competing priorities of conducting ePCTs in people living with dementia (PLWD) and their care partners, protecting the interests of participants, and assuring health care systems that regulatory issues are addressed. Learn more about the core’s work from Core Leader Jason Karlawish, MD. |
| | The NIA IMPACT Health Equity Team (Video) | Featured Videos | 3/11/2020 | (Video) The Health Equity Team (HET) focuses on developing and implementing strategies to address diversity and inclusion in the conduct of ePCTs for people living with dementia (PLWD) and their care partners to ensure the IMPACT Collaboratory is a national resource for all Americans afflicted with dementia. Learn more about how the HET is working to increase health equity in dementia care from Core Leader Ana Quiñones, PhD, MS. |
| | Stakeholder Engagement Report on Research Priorities | Reports | 3/31/2020 | This report from the IMPACT Stakeholder Engagement Team (SET), led by Gary Epstein-Lubow, MD, and Katie Maslow, MSW, regarding stakeholder research priorities, is a compilation of work beginning with input from the NIA IMPACT Collaboratory’s Stakeholder Advisory Committee (SAC) and finalized after additional SET discussion during and following the NIA IMPACT Collaboratory in-person meeting January 28 & 29, 2020. SET conducted a one-day in-person meeting on December 3, 2019 including members of the SAC and additional participants relevant to the IMPACT Collaboratory’s efforts regarding stakeholder engagement.
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