Drs. Jacqueline Corrigan-Curay, Josh Denny, and Patrick Heagerty discuss current and future directions for generating real-world evidence. This webinar is part of the NIH Collaboratory's special EHR Workshop Grand Rounds Series, "Advances at the Intersection of Digital Health, Electronic Health Records and Pragmatic Clinical Trials"; Part 2: "Real World Evidence: Contemporary Experience and Future Directions"; May 8, 2020.